PCT对脓毒症的诊断及预后价值探讨
Discussion on the Diagnostic and Prognostic Value of PCT in Sepsis
DOI: 10.12677/MD.2022.122019, PDF,   
作者: 樊玉娟, 徐洁莹, 周 宇*：大理大学临床医学院，云南 大理
关键词: 脓毒症；降钙素原；诊断；Sepsis； PCT； Diagnostic
摘要: 目的：探讨降钙素原(Procalcitonin, PCT)对脓毒症的诊断及预后价值。方法：收集2020年9月~2021年9月于大理大学第一附属医院就诊的40例健康体检者、40例入住ICU病房非脓毒症患者及60例脓毒症患者的相关资料，随后根据脓毒症患者预后分成生存组(n = 36)及死亡组(n = 24)，比较不同组别中的PCT水。结果：脓毒症组PCT水平显著高于病例对照组及健康对照组(P < 0.05)，脓毒症死亡组PCT水平显著高于生存组(P < 0.05)；受试者工作特征(Receiver Operating Characteristic Curve, ROC)曲线分析表明PCT对脓毒症的诊断性能及预后判断价值较高。结论：PCT对脓毒症有较好的诊断效能，并对其预后有较高的预测价值，为临床的进一步应用奠定了基础。
Abstract: Objective: To investigate the diagnostic and prognostic value of Procalcitonin (PCT) in sepsis. Methods: Relevant data were collected from 40 healthy check-ups, 40 non-septic patients admitted to the ICU ward and 60 septic patients attending the First Affiliated Hospital of Dali University from September 2020 to September 2021, and subsequently divided into survival groups (n = 36) and death group (n = 24) according to the prognosis of septic patients, and compared PCT water in different groups. Results: PCT levels were significantly higher in the sepsis group than in the case- control and healthy control groups (P < 0.05) and in the sepsis death group (P < 0.05); subject work characteristic (ROC) curve analysis showed that PCT has a high value for diagnostic performance and prognostic judgment of sepsis. Conclusion: PCT has better diagnostic efficacy for sepsis and higher predictive value for its prognosis, which lays the foundation for further clinical application.
文章引用：樊玉娟, 徐洁莹, 周宇. PCT对脓毒症的诊断及预后价值探讨[J]. 医学诊断, 2022, 12(2): 124-129. https://doi.org/10.12677/MD.2022.122019

参考文献

[1] Lee, S., Song, J., Park, D., et al. (2022) Diagnostic and Prognostic Value of Presepsin and Procalcitonin in Non-Infectious Organ Failure, Sepsis, and Septic Shock: A Prospective Observational Study According to the Sepsis-3 Definitions. BMC Infectious Diseases, 22, Article No. 8. [Google Scholar] [CrossRef] [PubMed]
[2] Xiao, H., Jia, H., Yuan, X., et al. (2021) The Value of Dynamic Monitoring of Procalcitonin in the Early Identification of Pathogens and Prognosis of Bloodstream Infections in the ICU. Annals of Palliative Medicine, 10, 12208-12217. [Google Scholar] [CrossRef] [PubMed]
[3] Devia Jaramillo, G. and Ibáñez Pinilla, M. (2022) Quick Sequential Organ Failure Assessment, Sequential Organ Failure Assessment, and Procalcitonin for Early Diagnosis and Prediction of Death in Elderly Patients with Suspicion of Sepsis in the Emergency Department, Based on Sepsis-3 Definition. Gerontology, 68, 171-180. [Google Scholar] [CrossRef] [PubMed]
[4] Zhang, K., Zhang, S., Cui, W., et al. (2021) Development and Validation of a Sepsis Mortality Risk Score for Sepsis-3 Patients in Intensive Care Unit. Frontiers in Medicine, 7, Article NO. 609759. [Google Scholar] [CrossRef] [PubMed]
[5] Teng, A. and Wilcox, A. (2020) A Review of Predictive Analytics Solutions for Sepsis Patients. Applied Clinical Informatics, 11, 387-398. [Google Scholar] [CrossRef] [PubMed]
[6] Li, Y., Yan, C., Gan, Z., et al. (2020) Prognostic Values of SOFA Score, qSOFA Score, and LODS Score for Patients with Sepsis. Annals of Palliative Medicine, 9, 1037-1044. [Google Scholar] [CrossRef] [PubMed]
[7] Godínez-Vidal, A., Alcántara-Gordillo, R., Aguirre-Rojano, V., et al. (2020) Evaluation of C-Reactive Protein, Procalcitonin and the PCR/PCT Index as Indicators of Mortality in Abdominal Sepsis. Cirugia y Cirujanos, 88, 150-153. [Google Scholar] [CrossRef] 
[8] LIN, R., HU, H., LI, L., et al. (2020) The Potential of microRNA-126 in Predicting Disease Risk, Mortality of Sepsis, and Its Correlation with Inflammation and Sepsis Severity. Journal of Clinical Laboratory Analysis, 34, e23408. [Google Scholar] [CrossRef] [PubMed]
[9] Shomali, N., Mahmoodpoor, A., Abbas Abad, A., et al. (2022) The Relationship between Extracellular/Intracellular microRNAs and TLRs May Be Used as a Diagnostic and Therapeutic Approach in Sepsis. Immunological Investigations, 51, 154-169. [Google Scholar] [CrossRef] [PubMed]