MicroRNA-122在肥胖及2型糖尿病中的研究进展
Research Progress of MicroRNA-122 in Obesity and Type 2 Diabetes
DOI: 10.12677/ACM.2022.126824, PDF,   
作者: 潘路路, 林 波:山东省潍坊医学院,山东 潍坊;马小莉, 赵慧琛:青岛大学附属青岛市市立医院内分泌科,山东 青岛;王 蕾, 左 丹, 张玉超*:青岛大学附属青岛市市立医院临床研究中心,山东 青岛;刘元涛:山东大学齐鲁医院青岛院区,山东 青岛
关键词: miR-122肥胖2型糖尿病研究进展miR-122 Obesity Type 2 Diabetes Research Progress
摘要: 糖尿病的患病率呈现逐年上升的趋势,其中罹患2型糖尿病的人群占到总糖尿病患病人数的90%,而在糖尿病患者中超重人群占比约41%、肥胖人群占比约24.3%,早期诊断,早期干预肥胖与2型糖尿病对于人类的健康非常重要。miR-122在肥胖及2型糖尿病发生发展中具有重要的调控作用,且具有一定的诊断性能。本文主要针对miR-122在肥胖以及2型糖尿病相关方面的研究进展进行阐述。
Abstract: The prevalence of diabetes is on the rise year by year. The people suffering from type 2 diabetes account for 90% of the total diabetes patients. Among diabetes patients, overweight people account for about 41% and obese people account for about 24.3%. Early diagnosis and early intervention of obesity and type 2 diabetes are very important for human health. miR-122 plays an important reg-ulatory role in the occurrence and development of obesity and type 2 diabetes, and has certain di-agnostic performance. This article focuses on the research progress of miR-122 in obesity and type 2 diabetes.
文章引用:潘路路, 林波, 马小莉, 王蕾, 左丹, 赵慧琛, 刘元涛, 张玉超. MicroRNA-122在肥胖及2型糖尿病中的研究进展[J]. 临床医学进展, 2022, 12(6): 5706-5712. https://doi.org/10.12677/ACM.2022.126824

参考文献

[1] 朱于坚. 肥胖2型糖尿病奥利司他治疗效果的初步观察[J]. 海峡药学, 2016, 28(6): 162-163.
[2] 中华医学会内分泌学分会. 中国2型糖尿病合并肥胖综合管理专家共识[J]. 糖尿病天地(临床), 2016, 10(9): 392-394.
[3] American Diabetes Association (2019) Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes—2019. Diabetes Care, 42, 81-89. [Google Scholar] [CrossRef
[4] Lim, E.L., Hollingsworth, K.G., Aribisala, B.S., et al. (2011) Reversal of Type 2 Diabetes: Normalization of Beta Cell Function in Association with Decreased Pancreas and Liver Triacylglycerol. Diabetologia, 54, 2506-2514. [Google Scholar] [CrossRef] [PubMed]
[5] Huang, X.Y., Chen, J.X., Ren, Y., et al. (2022) Exosomal miR-122 Promotes Adipogenesis and Aggravates Obesity through the VDR/SREBF1 Axis. Obesity (Silver Spring), 30, 666-679. [Google Scholar] [CrossRef] [PubMed]
[6] Lee, H.M., Wong, W.K., Fan, B.Q., et al. (2021) Detection of In-creased Serum miR-122-5p and miR-455-3p Levels before the Clinical Diagnosis of Liver Cancer in People with Type 2 Diabetes. Scientific Reports, 11, Article No. 23756. [Google Scholar] [CrossRef] [PubMed]
[7] Mohany, K.M., Al Rugaie, O., Al-Wutayd, O. and Al-Nafeesah, A. (2021) Investigation of the Levels of Circulating miR-29a, miR-122, Sestrin 2 and Inflammatory Markers in Obese Children with/without Type 2 Diabetes: A Case Control Study. BMC Endocrine Disorders, 21, Article No. 152. [Google Scholar] [CrossRef] [PubMed]
[8] 董敏. 利拉鲁肽对我国肥胖2型糖尿病患者减重治疗的现状及进展[J]. 天津药学, 2021, 33(5): 74-78.
[9] Hulsmans, M., De Keyzer, D. and Holvoet, P. (2011) MicroRNAs Regulating Oxidative Stress and Inflammation in Relation to Obesity and Atherosclerosis. The FASEB Journal, 25, 2515-2527. [Google Scholar] [CrossRef] [PubMed]
[10] Kim, D. and Scherer, P.E. (2021) Obesity, Diabetes, and Increased Cancer Progression. Diabetes & Metabolism Journal, 45, 799-812. [Google Scholar] [CrossRef] [PubMed]
[11] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版) [J]. 中华糖尿病杂志, 2021, 13(4): 315-409.
[12] Shaw, J.E., Sicree, R.A. and Zimmet, P.Z. (2010) Global Estimates of the Prevalence of Diabetes for 2010 and 2030. DIABETES RES CLIN PR, 87, 4-14. [Google Scholar] [CrossRef] [PubMed]
[13] Ying, S.Y., Chang, D.C., Miller, J.D., et al. (2006) The Mi-croRNA: Overview of the RNA Gene That Modulates Gene Functions. In: Ying, S.Y., Ed., MicroRNA Protocols. Methods in Molecular Biology, Vol. 342, Humana Press, Totowa, 1-18. [Google Scholar] [CrossRef] [PubMed]
[14] Tanzer, A. and Stadler, P.F. (2006) Evolution of microRNAs. In: Ying, S.Y., Ed., MicroRNA Protocols. Methods in Molecular Biology, Vol. 342, Humana Press, Totowa, 335-350. [Google Scholar] [CrossRef] [PubMed]
[15] Fernandez-Valverde, S.L., Taft, R.J. and Mattick, J.S. (2011) Mi-croRNAs in β-Cellbiology, Insulin Resistance, Diabetes and Its Complications. Diabetes, 60, 1825-1831. [Google Scholar] [CrossRef] [PubMed]
[16] Fang, Q., Chen, W., Jian, Y.R., et al. (2022) Serum Expression Level of MicroRNA-122 and Its Significance in Patients with Hepatitis B Virus Infection. Journal of Healthcare Engineering, 2022, Article ID: 8430276. [Google Scholar] [CrossRef] [PubMed]
[17] 孟昶, 朱磊. miR-122对脂代谢影响的研究进展[J]. 辽宁体育科技, 2019, 41(2): 31-35. [Google Scholar] [CrossRef
[18] Refeat, M.M., Hassan, N.A.-M., Ahmad, I.H., et al. (2021) Correlation of Circulating miRNA-33a and miRNA-122 with Lipid Metabolism among Egyptian Patients with Metabolic Syndrome. Journal of Genetic Engineering and Biotechnology, 19, Article No. 147. [Google Scholar] [CrossRef] [PubMed]
[19] Benatti, R.O., Melo, A.M., Borges, F.O., et al. (2014) Maternal High-Fat Diet Consumption Modulates Hepatic Lipid Metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) Expression in Offspring. British Journal of Nutrition, 111, 2112-2122. [Google Scholar] [CrossRef
[20] Baselga, E.L., Blade, C., Ribas, L.A., et al. (2014) Chronic Sup-plementation of Proanthocyanidins Reduces Postprandial Lipemia and Liver miR-33a and miR-122 Levels in a Dose-Dependent Manner in Healthy Rats. The Journal of Nutritional Biochemistry, 25, 151-156. [Google Scholar] [CrossRef] [PubMed]
[21] López-Pastor, A.R., Infante-Menéndez, J., González-Illanes, T., et al. (2021) Concerted Regulation of Non-Alcoholic Fatty Liver Disease Progression by microRNAs in Apolipoprotein E-Deficient Mice. Disease Models & Mechanisms, 14, Article ID: dmm049173. [Google Scholar] [CrossRef] [PubMed]
[22] Hu, Y.Y., Peng, X.T., Du, G.P., et al. (2022) MicroRNA-122-5p Inhi-bition Improves Inflammation and Oxidative Stress Damage in Dietary-Induced Non-Alcoholic Fatty Liver Disease through Targeting FOXO3. Front Physiol, 13, Article ID: 803445. [Google Scholar] [CrossRef] [PubMed]
[23] Zinkhan, E.K., Yu, B. and Schlegel, A. (2018) Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part through MicroRNA-122 Inhibition of Cyp7a1. Frontiers in Physiology, 9, 645. [Google Scholar] [CrossRef] [PubMed]
[24] Cirera, S., Birck, M., Busk, P.K., et al. (2010) Expression Profiles of miRNA-122 and Its Target CAT1 in Minipigs (Sus scrofa) Fed a High-Cholesterol Diet. Comparative Medicine, 60, 136-141.
[25] Ghosh, J., Bose, M., Roy, S., et al. (2013) Leishmania Donovani Targets Dicerl to Downregulate miR-122, Lower Serum Cholesterol, and Facilitate Murine Liver Infection. Cell Host & Microbe, 13, 277-288. [Google Scholar] [CrossRef] [PubMed]
[26] Wu, G.Y., Rui, C., Chen, J.Q., et al. (2017) MicroRNA-122 In-hibits Lipid Droplet Formation and Hepatic Triglyceride Accumulation via Yin Yang 1. Cellular Physiology and Bio-chemistry, 44, 1651-1664. [Google Scholar] [CrossRef] [PubMed]
[27] Shukla, U., Tumma, N., Gratsch, T., et al. (2013) Insights into Insu-lin-Mediated Regulation of CYP2E1: miR-132/-212 Targeting of CYP2E1 and Role of Phosphatidylinositol 3-Kinase, Akt (Protein Kinase B), Mammalian Target of Rapamycin Signaling in Regulating miR-132/-212 and miR-122/-181a Ex-pression in Primary Cultured Rat Hepatocytes. Drug Metabolism and Disposition, 41, 1769-1777. [Google Scholar] [CrossRef] [PubMed]
[28] 陈丽霞, 张秀薇, 禤文婷, 等. miR-101、miR-122在妊娠期糖尿病患者血清和胎盘组织中表达及意义[J]. 广东医科大学学报, 2021, 39(3): 267-270.
[29] 魏胜男. 黄癸固体分散体通过调控肝脏HNF4α/miR-122通路纠正糖尿病糖脂代谢紊乱机制研究[D]: [博士学位论文]. 长春: 吉林大学, 2016.
[30] Mahjoob, G., Ahmadi, Y., Fatima, R.H., et al. (2022) Circulating microRNAs as Predictive Biomarkers of Coronary Artery Diseases in Type 2 Diabetes Patients. Journal of Clinical Laboratory Analysis, 36, e24380. [Google Scholar] [CrossRef] [PubMed]
[31] Liu, X.H., Xu, H.L., Zang, Y.H., et al. (2022) Radix Rehmannia Glutinosa Inhibits the Development of Renal Fibrosis by Regulating miR-122-5p/PKM Axis. American Journal of Translational Research, 14, 103-119.
[32] Cheng, L., Qiu, X.Y., He, L.Y., et al. (2022) MicroRNA-122-5p Ameliorates Tubular In-jury in Diabetic Nephropathy via FIH-1/HIF-1α Pathway. Renal Failure, 44, 293-303. [Google Scholar] [CrossRef
[33] Zang, L., Gao, F., Huang, A.J., et al. (2022) Icariin Inhibits Epithelial Mesenchymal Transition of Renal Tubular Epithelial Cells via Regulating the miR-122-5p/FOXP2 Axis in Di-abetic Nephropathy Rats. Journal of Pharmacological Sciences, 148, 204-213. [Google Scholar] [CrossRef] [PubMed]
[34] Pastukh, N., Meerson, A., Kalish, D., et al. (2019) Serum miR-122 Levels Correlate with Diabetic Retinopathy. Clinical and Experimental Medicine, 19, 255-260. [Google Scholar] [CrossRef] [PubMed]
[35] Li, K.L., Yan, G.H., Huang, H.J., et al. (2022) An-ti-Inflammatory and Immunomodulatory Effects of the Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells on Osteoarthritis via M2 Macrophages. Journal of Nanobiotechnology, 20, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[36] 刘利慧, 周波, 王霜, 等. 伴腹型肥胖2型糖尿病患者胰岛素抵抗指数与脂肪细胞脂肪酸结合蛋、血尿酸水平密切相关[J]. 内科急危重症杂志, 2021, 27(4): 310-314.