SLCO1B1 & ApoE基因多态性与他汀类治疗疗效相关性的研究

Study on the Correlation between SLCO1B1 & ApoE Gene Polymorphisms and the Efficacy of Statin Therapy

摘要: 目的：了解江西赣南地区SLCO1B1 & ApoE基因多态性的分布情况及其与治疗急性缺血性卒中疗效的相关性。方法：严格按照病例纳入和排除标准，连续募集2021年1月1日至2021年6月30日期间，在赣南医学院第一附属医院住院诊断为急性缺血性卒中的患者，常规按急性缺血性脑卒中诊治指南进行治疗，并给予SLCO1B1 & ApoE基因检测，同时监测其肝功能、血脂，记录肌痛情况。结果：SLCO1B1基因型包括*1a/*1a、*1a/*1b、*1b/*1b、*1a/*5、*1a/*15、*1b/*15、*5/*5、*5/*15、*15/*15，患者所占比例分别为23.08%、25.82%、19.52%、1.92%、8.24%、14.56%、1.92%、3.02%、1.92%。ApoE基因型包括E2/E2、E2/E3、E2/E4、E3/E3、E3/E4、E4/E4，患者所占比例为1.10%、4.40%、13.46%、60.16%、18.41%、2.47%。结论：SLCO1B1 & ApoE基因检测利于个体化他汀类药物治疗。

Abstract: Objective: To investigate the distribution of SLCO1B1 & ApoE gene polymorphism and its correlation with the therapeutic effect of acute ischemic stroke in the Gannan area of Jiangxi Province. Methods: In strict accordance with the inclusion and exclusion criteria, patients diagnosed with acute ischemic stroke in our hospital from January 1, 2021, to June 30, 2021, were recruited continuously, and were given SLCO1B1 & ApoE gene tests. Meanwhile, their liver function and blood li-pid were monitored, and myalgia was recorded. Results: SLCO1B1 gene types including the *1a/*1a, *1a/*1b,*1b/*1b, *1a/*5, *1a/*15, *1b/*15, *5/*5, *5/*15, and *15/*15. The proportion of patients were 23.08%, 25.82%, 19.52%, 1.92%, 8.24%, 14.56%, 1.92%, 3.02%, , and 1.92%, respectively. ApoE geno types including E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, and E4/E4, and the proportion of patients was 1.10%, 4.40%, 13.46%, 60.16%, 18.41%, and 2.47%. Conclusion: SLCO1B1 & ApoE gene detection is beneficial to individualized statin therapy.