振幅整合脑电图在早产儿脑损伤诊断中的应用

Application of Amplitude Integrated EEG in the Diagnosis of Brain Injury in Premature Infants

摘要: 目的：探讨振幅整合脑电图在早产儿脑损伤诊断中的应用。方法：选取2020年5月~2021年11月期间在生后24 h内入住本院的早产儿97例为研究对象，均行头颅核磁共振成像(MRI)检测，按照有无异常将其分为脑损伤组(n = 32)和非脑损伤组(n = 65)，比较两组振幅整合脑电图诊断情况。结果：诊断后，脑损伤组图形连续性，宽带，睡眠–觉醒周期，下边界振幅及总分均低于非脑损伤组(P < 0.05)，诊断后，脑损伤组患者振幅整合脑电图轻度及重度异常占比高于非脑损伤组(P < 0.05)。结论：振幅整合脑电图能够早期诊断早产儿脑损伤症状，并且在应用过程中操作简便，具无创性，直观显示诊断结果，还能有效反应早产儿脑功能改变情况，加强后期危险因素防治。

Abstract: Objective: To explore the application of amplitude integrated aEEG in the diagnosis of brain injury in premature infants. Methods: 97 premature infants who were admitted to our hospital within 24 hours after birth from May 2020 to November 2021 were selected as the research objects. All of them were examined by cranial magnetic resonance imaging (MRI). They were divided into brain injury group (n = 32) and non brain injury group (n = 65) according to whether there were abnor-malities. The amplitude integrated EEG diagnosis of the two groups was compared. Results: After diagnosis, the map continuity, broadband, sleep wake cycle, lower boundary amplitude and total score of brain injury group were lower than those of non brain injury group (P < 0.05). After diagno-sis, the proportion of mild and severe abnormalities of amplitude integrated EEG in brain injury group was higher than that of non brain injury group (P < 0.05). Conclusion: Amplitude integrated electroencephalogram can early diagnose the symptoms of brain injury in preterm infants, and it is simple, noninvasive, visually display the diagnostic results, effectively reflect the changes of brain function in preterm infants, and strengthen the prevention and treatment of late risk factors.