国家中药复方专利治疗银屑病的用药规律分析

Analysis on Medication Rules of TCM Compound with National Patent for Treatment of Psoriasis

摘要: 目的：探讨中药专利治疗银屑病的用药规律。方法：以专利检索及分析系统为数据源，检索近10年相关专利。利用古今医案云平台(网页版)、SPSS modeler 18.0软件、SPSS statistics 25.0软件，将纳入的339首处方进行中药频次、四气五味及归经统计、关联规则分析、因子分析。结果：得到药物721味，高频药物31味，功效多为清热凉血、清热燥湿、清热解毒、补气、活血调经等，四气以寒、温、平为主，五味以苦、甘、辛为主，归经多为肝、心、胃经。关联规则分析得到15组药对，因子分析得到10个特征值大于1的公因子。结论：国家中药专利复方治疗银屑病多以清热为主，兼以解表、除湿、活血、补虚。得到的结果具有一定应用价值，但还需进一步研究。

Abstract: Objective: To explore the medication law of traditional Chinese medicine patent in the treatment of psoriasis. Methods: The patent search and analysis system was used as the data source to search the relevant patents in recent 10 years. Using the ancient and modern medical case cloud platform (WEB version), SPSS modeler 18.0 software and SPSS statistics 25.0 software, the 339 prescriptions included were analyzed for the frequency of traditional Chinese medicine, the statistics of four Qi and five flavors and their meridians, association rule analysis and factor analysis. Results: 721 drugs and 31 high-frequency drugs were obtained. Most of the effects were clearing heat and cooling blood, clearing heat and dampness, clearing heat and detoxification, tonifying Qi, activating blood circulation and regulating menstruation. The four Qi were mainly cold, warm and flat, the five flavors were mainly bitter, sweet and pungent, and the meridians were mostly liver, heart and stomach meridians. 15 drug pairs were obtained by association rule analysis, and 10 common factors with eigenvalues greater than 1 were obtained by factor analysis. Conclusion: The treatment of psoriasis with national Chinese medicine patent compound is mainly to clear heat, and also to relieve the surface, dehumidification, invigorate blood, tonic deficiency. The results obtained have certain application value, but further research is needed.