结直肠癌术后吻合口瘘的最新临床研究进展
The Latest Clinical Research Progress of Anastomotic Fistula after Colorectal Cancer Surgery
摘要: 结直肠癌是我国常见的消化道恶性肿瘤之一,严重威胁人们生命健康,而目前对于进展期结直肠癌,手术仍然是一种重要的治疗方式,术后吻合口瘘,可增加患者死亡率。因此结直肠癌术后吻合口瘘危险因素、诊断及治疗仍然是一个需要进一步深入研究的问题。本文就结直肠癌术后吻合口瘘相关危险因素,诊断、治疗及相关预防做一综诉。
Abstract: Colorectal cancer is one of the common digestive tumors in China, which seriously threatens peo-ple’s health. At present, surgery is still an important treatment for advanced colorectal cancer, and postoperative anastomotic fistula can increase the mortality of patients. Therefore, the risk factors, diagnosis and treatment of anastomotic fistula after colorectal cancer surgery are still a problem that needs further research. This article reviews the risk factors, diagnosis and treatment of anas-tomotic fistula after colorectal cancer operation.
文章引用:张晓静, 马玉滨. 结直肠癌术后吻合口瘘的最新临床研究进展[J]. 临床医学进展, 2022, 12(7): 6291-6296. https://doi.org/10.12677/ACM.2022.127909

参考文献

[1] Boyle, P. and Leon, M.E. (2002) Epidemiology of Colorectal Cancer. British Medical Bulletin, 64, 1-25. [Google Scholar] [CrossRef] [PubMed]
[2] 叶德敬, 刘超英, 张雨洁. 结直肠癌的流行病学及研究现状[J]. 世界最新医学信息文摘, 2016, 16(A2): 34-35.
[3] Vasiliu, E.C., Zarnescu, N.O., Costea, R. and Neagu, S. (2015) Review of Risk Factors for Anastomotic Leakage in Colorectal Surgery. Chirurgia, 110, 319-326.
[4] Arron, M.N.N., Greijdanus, N.G., Ten Broek, R.P.G., Dekker, J.W.T., van Workum, F., van Goor, H., Tanis, P.J. and de Wilt, J.H.W. (2021) Trends in Risk Factors of Anastomotic Leakage after Colorectal Cancer Surgery (2011-2019): A Dutch Popula-tion-Based Study. Colorectal Disease, 23, 3251-3261. [Google Scholar] [CrossRef] [PubMed]
[5] Ionescu, D., Tibrea, C. and Puia, C. (2013) Pre-Operative Hypoalbuminemia in Colorectal Cancer Patients Undergoing Elective Surgery—A Major Risk Factor for Postoperative Outcome. Chirurgia (Bucur), 10, 822-828.
[6] 曾庆智, 黄启奎, 邓杰建. 结直肠癌患者术后吻合口瘘发生的危险因素分析[J]. 中国临床新医学, 2019, 12(11): 1236-1239.
[7] Huang, Y., Tang, S.R. and Young, C.J. (2018) Nonsteroidal Anti-Inflammatory Drugs and Anastomotic Dehiscence after Colorectal Sur-gery: A Meta-Analysis. ANZ Journal of Surgery, 88, 959-965. [Google Scholar] [CrossRef] [PubMed]
[8] Gong, J.P., Yang, L., Huang, X.E., Sun, B.C., Zhou, J.N., Yu, D.S., Zhou, X., Li, D.Z., Guan, X. and Wang, D.F. (2014) Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery. Asian Pacific Journal of Cancer Pre-vention, 15, 707-712. [Google Scholar] [CrossRef
[9] 袁荣华, 翟晓峰. 腹腔镜下结直肠癌根治术后吻合口瘘危险因素分析[J]. 中华腔镜外科杂志(电子版), 2013, 6(6): 454-457.
[10] 吴红杰, 邹小明. 结直肠癌术后吻合口瘘的诊治及预防[J]. 中华结直肠疾病电子杂志, 2016, 5(2): 171-174.
[11] 李柱, 廖信芳, 吕海钠, 向德雨, 侯美君. 血清CRP、腹腔引流液CRP在预测腹腔镜结直肠癌术后吻合口瘘的临床价值[J]. 广州医科大学学报, 2021, 49(3): 77-82.
[12] 孟闯, 张跃, 姚泽明, 王建. 直肠癌患者根治术后盆腔引流液MMP-2、MMP-9、CRP、IL-1β、 TNF-α预测早期吻合口瘘的临床价值[J]. 国际检验医学杂志, 2021, 42(22): 2772-2775.
[13] Kauv, P., Benadjaoud, S., Curis, E., Boulay-Coletta, I., Loriau, J., Zins, M., 麦筱莉. 结直肠术后吻合口瘘: CT诊断的准确性[J]. 国际医学放射学杂志, 2016, 39(1): 97.
[14] 施显军. 预后营养指数在结直肠癌术后发生吻合口瘘中的价值[D]: [硕士学位论文]. 重庆: 重庆医科大学, 2021.
[15] 吴国刚, 刘兆润, 冷梅, 王明辉, 刘吉盛, 富民. 降钙素原与C反应蛋白在预测结直肠癌手术后吻合口瘘的临床价值[J]. 中华普通外科学文献(电子版), 2018, 12(4): 228-232.
[16] Chen, W.T., Bansal, S., Ke, T.W., Chang, S.-C., Huang, Y.-C., Fingerhut, A., et al. (2018) Combined Repeat Laparoscopy and Transanal Endolumenal Repair (Hybrid Approach) in the Early Management of Postoperative Colorectal Anastomotic Leaks: Technique and Outcomes. Surgical Endoscopy, 32, 4472-4480. [Google Scholar] [CrossRef] [PubMed]
[17] Vennix, S., Abegg, R. and Bakker, O.J. (2013) Surgical Re-Interventions Following Colorectal Surgery: Open versus Laparoscopic Management of Anastomotic Leakage. Jour-nal of Laparoendoscopic & Advanced Surgical Techniques, 23, 739-744. [Google Scholar] [CrossRef] [PubMed]
[18] Vignali, A., Elmore, U., Aleotti, F., Roberto, D., Parise, P. and Rosati, R. (2021) Re-Laparoscopy in the Treatment of Anastomotic Leak Following Laparoscopic Right Colectomy with Intra-corporeal Anastomosis. Surgical Endoscopy, 35, 6173-6178. [Google Scholar] [CrossRef] [PubMed]
[19] 谭国强, 王宏新. 腹腔双套管持续冲洗引流在结直肠吻合口瘘中的临床观察[J]. 中国医药指南, 2013, 11(16): 77-78. [Google Scholar] [CrossRef
[20] Yan, S., Sun, H., Li, Z., Liu, S. and Han, B. (2020) Con-servative Treatment of Rectovesical Fistula after Leakage Following Laparoscopic Radical Resection of Rectal Cancer. Journal of International Medical Research, 48, Article ID: 300060520914835. [Google Scholar] [CrossRef] [PubMed]
[21] 王会涛, 孙晓光, 刘瑞杰, 吴吉海. 生长抑素在结直肠术后肠瘘中的应用价值分析[J]. 安徽卫生职业技术学院学报, 2014, 13(2): 26-27.
[22] 陈康寿, 吴雄辉, 黄伟, 张维燕. 生长抑素在腹腔镜结直肠癌根治术后的临床应用效果观察[J]. 中国医药科学, 2017, 7(11): 65-67+123.
[23] 张巍巍, 徐炳欣, 菅书明. 复方泛影葡胺注射液在直肠癌术后吻合口瘘治疗中的应用研究[J]. 河南医学研究, 2017, 26(11): 1938-1940.
[24] Kayano, H., Nomura, E., Ueda, Y., Machida, T., Uda, S., Mukai, M., Yamamoto, S. and Ma-kuuchi, H. (2021) Short- Term Outcomes of OTSC for Anastomotic Leakage after Laparoscopic Colorectal Surgery. Minimally Invasive Therapy & Allied Technologies, 30, 369-376. [Google Scholar] [CrossRef] [PubMed]
[25] Strangio, G., Zullo, A., Ferrara, E.C., Anderloni, A., Carlino, A., Jovani, M., Ciscato, C., Hassan, C. and Repici, A. (2015) Endo-Sponge Therapy for Management of Anastomotic Leakages after Colorectal Surgery: A Case Series and Review of Literature. Digestive and Liver Disease, 47, 465-469. [Google Scholar] [CrossRef] [PubMed]
[26] 叶鹏飞, 张晓辉, 徐纪中, 王贵宪. 直肠癌吻合口漏临床治疗体会[J]. 河南医学研究, 2016, 25(7): 1242-1243.
[27] 郭杰明, 徐婷婷. 低位直肠癌保肛术吻合口瘘原因分析及防治策略[J]. 现代仪器与医疗, 2016, 22(1): 58-60+98.
[28] 张迎泽, 宋国权, 王茂龙. 直肠癌术后吻合口瘘的研究进展[J]. 牡丹江医学院学报, 2022, 43(1): 140-144.
[29] Yeh, C.Y. and Tang, R. (2005) Pelvic Drainage and Other Risk Factors for Leakage after Elective Anterior Resection in Rectal Cancer Patients: A Prospective Study of 978 Patients. Annals of Surgery, 242, 902-903. [Google Scholar] [CrossRef