3.0T动态增强MRI的背景实质增强和乳腺癌临床分期、分子病理类型及术后胸壁复发的相关性研究

Correlation of BPE of 3.0T Dynamic Enhanced MRI and Clinical Stage, Molecular Pathological Type, Postoperative Chest Wall Recurrence of Breast Cancer

摘要: 目的：探讨根治术前乳腺3.0T-动态增强MRI背景实质增强(BPE)与乳腺癌临床分期、分子病理类型及术后胸壁复发之间的相关性。方法：回顾性分析194例行根治术的乳腺癌患者，收集患者术前MRI背景实质增强(BPE)、肿瘤临床分期、分子病理类型、术后胸壁复发等相关资料，统计分析BPE与其余三者之间的相关性。结果：乳腺癌MRI的背景实质增强(BPE)和肿瘤大小、淋巴结转移、核分级、组织病理分级、淋巴结包膜浸润、ER和PR的表达等均无相关性；BPE与HER-2的高表达具有一定相关性(P = 0.07)，和Ki-67大于14%具有一定相关性(P = 0.08)，与多个乳腺癌病灶数(P = 0.04)、术后胸壁复发率具有显著统计学差异(P = 0.045)。结论：乳腺高MRI背景实质强度是乳腺癌术后胸壁复发的独立预后因素，BPE能否成为潜在的乳腺癌的生物标记，值得进一步研究。

Abstract: Objective: To investigate the correlation between 3.0T-dynamic contrast-enhanced MRI background parenchyma enhancement (BPE) before radical mastectomy and clinical stage, molecular patholog-ical type and chest wall recurrence of breast cancer. Material and Methods: We retrospectively ana-lyzed 194 breast cancer patients who underwent radical surgery, and collected data related to the patients’ preoperative MRI background parenchymal enhancement (BPE), clinical stage of the tu-mor, molecular pathology type, and postoperative chest wall recurrence, and statistically analyzed the correlation between BPE and the remaining three. Results: BPE of the breast and chest wall re-currence (P = 0.045), high expression of HER-2 appears to be associated with BPE (P = 0.07). Multi-ple lesions of the mammary gland and Ki-67 greater than 14% also appeared to be associated with BPE (P = 0.08). And tumor the expression of and ER in the size of the lymph nodes, the metastasis of lymph nodes, the nuclear grade, the pathological grade, the infiltration of the lymph nodes, the ex-pression of PR and no correlation with BPE, but no obvious relationship among the molecular typ-ing. Conclusion: High background intensity is an independent prognostic factor for chest wall re-currence, and whether BPE can become a new potential biomarker for breast cancer is worthy of further study.