褪黑素在妊娠相关疾病中的研究进展
Research Progress of Melatonin in Pregnancy-Related Diseases
DOI: 10.12677/ACM.2022.127929, PDF,   
作者: 李忠媛, 雷康卿：甘肃中医药大学第一临床医学院(甘肃省人民医院)，甘肃 兰州；白 宏：甘肃省庆阳市镇原县第一人民医院，甘肃 庆阳；鲁 蕃, 孙晓彤*：甘肃省人民医院产科，甘肃 兰州
关键词: 褪黑素；妊娠相关疾病；Melatonin； Pregnancy Related Diseases
摘要: 褪黑素是一种松果体激素。据研究，褪黑素和妊娠之间的联系越来越密切。褪黑素的作用是多方面的，而妊娠是一个复杂的、连续的、多阶段过程。本文综述了褪黑素的作用以及在妊娠相关疾病中的作用，可以为妊娠相关疾病的预测评估、诊断治疗、甚至预后提供新视野。
Abstract: Melatonin is a pineal hormone. According to research, the connection between melatonin and pregnancy is getting closer and closer. The role of melatonin is multi-faceted, while pregnancy is a complex, continuous and multi-stage process. This paper reviews the role of melatonin and its role in pregnancy-related diseases, which can provide a new horizon for the prediction, evaluation, di-agnosis, treatment and even prognosis of pregnancy-related diseases.
文章引用：李忠媛, 白宏, 鲁蕃, 雷康卿, 孙晓彤. 褪黑素在妊娠相关疾病中的研究进展[J]. 临床医学进展, 2022, 12(7): 6444-6449. https://doi.org/10.12677/ACM.2022.127929

参考文献

[1] 刘哲宇, 孙铮. 褪黑素代谢模式的研究进展[J]. 生命科学, 2017, 29(2): 209-214.
[2] 陈冠敏, 黄宗锈, 林健, 等. 复合褪黑素片改善小鼠睡眠作用的研究[J]. 海峡预防医学杂志, 2018, 24(2): 68-70.
[3] 张波, 郭燕冰, 许继宗, 等. 变应性鼻炎患者血清褪黑素、一氧化氮水平的季节测定及临床意义[J]. 中国医刊, 2015, 50(4): 80-83.
[4] 韦慧君, 杜孟, 白宏英. 血清褪黑素、谷胱甘肽与帕金森氧化应激的相关性[J]. 中国医学科学院学报, 2019, 41(2): 183-187.
[5] 武琪, 陈亮, 张宝华. 帕金森病患者血清和脑脊液褪黑素水平变化及其临床意义[J]. 现代检验医学杂志, 2017, 32(5): 90-93.
[6] 徐志平, 闻纯, 王丽. 慢性肾衰患者褪黑素水平、氧化应激、炎症水平与骨密度相关性研究[J]. 中国骨质疏松杂志, 2020, 26(4): 485-489.
[7] 左斌, 夏晓枫, 车彪, 等. 褪黑素调控SIRT1/FOXO1通路延缓椎间盘髓核细胞退变的实验研究[J]. 解放军医药杂志, 2021, 33(10): 54-58.
[8] 王以典, 郭旭东, 康继贺, 等. 褪黑素在椎间盘退变中的研究进展[J]. 中国矫形外科杂志, 2022(1): 1-6.
[9] 李铮, 居培红, 刘蕾蕾, 等. 褪黑素对COPD患者生物节律紊乱、T淋巴细胞亚群及肿瘤坏死因子-α的影响[J]. 海南医学, 2019, 30(20): 2594-2597.
[10] 施琳, 赵剑. 褪黑素对爆震伤诱导小鼠肺损伤的保护作用及机制[J]. 中国医科大学学报, 2021, 50(9): 804-808.
[11] 张苏玥, 杜欣键, 杨乐, 等. 褪黑素改善小鼠溃疡性结肠炎的机制[J]. 军事医学, 1-5.
[12] Yildirim, G., Attar, R., Ozkan, F., et al. (2010) The Effects of Letrozole and Melatonin on Surgically In-duced Endometriosis in a Rat Model: A Preliminary Study. Fertility and Sterility, 93, 1787-1792. [Google Scholar] [CrossRef] [PubMed]
[13] 陈亦清, 朱雯婷, 李振华, 等. 褪黑素对卵巢癌SKOV3细胞侵袭、迁移和血管生成的影响[J]. 中南医学科学杂志, 2020, 48(4): 389-394.
[14] Lee, J.H., Yun, C.W., Han, Y.S., et al. (2018) Melatonin and 5-Fluorouracil Co-Suppress Colon Cancer Stem Cells by Regulating Cellular Prion Protein-Oct4 Axis. Journal of Pineal Research, 65, e12519. [Google Scholar] [CrossRef] [PubMed]
[15] Li, Y., Zou, J., Li, B., et al. (2021) Anticancer Effects of Melatonin via Reg-ulating lncRNA JPX-Wnt/β-Catenin Signalling Pathway in Human Osteosarcoma Cells. Journal of Cellular and Molec-ular Medicine, 25, 9543-9556. [Google Scholar] [CrossRef] [PubMed]
[16] Chen, K., Zhu, P., Chen, W., et al. (2021) Melatonin Inhibits Prolifera-tion, Migration, and Invasion by Inducing ROS-Mediated Apoptosis via Suppression of the PI3K/Akt/mTOR Signaling Pathway in Gallbladder Cancer Cells. Aging (Albany NY), 13, 22502-22515. [Google Scholar] [CrossRef] [PubMed]
[17] Ordoñez, R., Carbajo-Pescador, S., Prieto-Dominguez, N., et al. (2014) Inhibition of Matrix Metalloproteinase-9 and Nuclear Factor Kappa B Contribute to Melatonin Prevention of Motility and Invasiveness in HepG2 Liver Cancer Cells. Journal of Pineal Research, 56, 20-30. [Google Scholar] [CrossRef] [PubMed]
[18] Talib, W.H. (2020) A Ketogenic Diet Combined with Melatonin Overcomes Cisplatin and Vincristine Drug Resistance in Breast Carcinoma Syngraft. Nutrition, 72, Article ID: 110659. [Google Scholar] [CrossRef] [PubMed]
[19] Zhao, Q., Wang, W. and Cui, J. (2019) Melatonin Enhances TNF-α-Mediated Cervical Cancer HeLa Cells Death via Suppressing CaMKII/Parkin/Mitophagy Axis. Cancer Cell In-ternational, 19, 58. [Google Scholar] [CrossRef] [PubMed]
[20] Leja-Szpak, A., Jaworek, J., Pierzchalski, P., et al. (2010) Mela-tonin Induces Pro-Apoptotic Signaling Pathway in Human Pancreatic Carcinoma Cells (PANC-1). Journal of Pineal Re-search, 49, 248-255. [Google Scholar] [CrossRef] 
[21] Lu, J.J., Fu, L., Tang, Z., et al. (2016) Melatonin Inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and Activates Caspase/Cyto C Signaling to Enhance the Antitumor Activity of Berberine in Lung Cancer Cells. Oncotarget, 7, 2985-3001. [Google Scholar] [CrossRef] [PubMed]
[22] Wang, X., Wang, B., Zhan, W., et al. (2019) Melatonin Inhibits Lung Metastasis of Gastric Cancer in Vivo. Biomedicine & Pharmacotherapy, 117, Article ID: 109018. [Google Scholar] [CrossRef] [PubMed]
[23] 中华医学会妇产科学分会妊娠期高血压疾病学组. 妊娠期高血压疾病诊治指南(2020) [J]. 中华妇产科杂志, 2020, 55(4): 227-238.
[24] 熊振玲, 侯常, 朱云潇. 妊娠高血压患者C反应蛋白与褪黑素的检测及意义[J]. 中华全科医学, 2009, 7(8): 836-837.
[25] Shimada, M., Seki, H., Samejima, M., et al. (2016) Salivary Melatonin Levels and Sleep-Wake Rhythms in Pregnant Women with Hypertensive and Glucose Metabolic Disorders: A Prospective Analysis. BioScience Trends, 10, 34-41. [Google Scholar] [CrossRef] [PubMed]
[26] Uzun, M., Gencer, M., Turkon, H., et al. (2017) Effects of Melatonin on Blood Pressure, Oxidative Stress and Placental Expressions of TNFα, IL-6, VEGF and sFlt-1 in RUPP Rat Model of Preeclampsia. Archives of Medical Research, 48, 592-598. [Google Scholar] [CrossRef] [PubMed]
[27] Zuo, J. and Jiang, Z. (2020) Melatonin Attenuates Hypertension and Oxidative Stress in a Rat Model of L-NAME-Induced Gestational Hypertension. Vascular Medicine, 25, 295-301. [Google Scholar] [CrossRef] 
[28] Zeng, K., Gao, Y., Wan, J., et al. (2016) The Reduction in Circu-lating Levels of Melatonin May Be Associated with the Development of Preeclampsia. Journal of Human Hypertension, 30, 666-671. [Google Scholar] [CrossRef] [PubMed]
[29] Man, G.C.W., Zhang, T., Chen, X., et al. (2017) The Regu-lations and Role of Circadian Clock and Melatonin in Uterine Receptivity and Pregnancy—An Immunological Perspec-tive. American Journal of Reproductive Immunology, 78, e12739. [Google Scholar] [CrossRef] [PubMed]
[30] 郑德洙, 姜钧文. 妊娠期高血压疾病的中医研究进展[J]. 按摩与康复医学, 2022, 13(6): 74-77.
[31] 杨志芬, 王春洋. 2021年妊娠期糖尿病相关诊疗指南解读[J]. 河北医科大学学报, 2021, 42(9): 993-997+1021.
[32] Xu, Y.-H., Shi, L., Bao, Y.-P., et al. (2018) Association between Sleep Duration during Pregnancy and Gestational Diabetes Mellitus: A Meta-Analysis. Sleep Medicine, 52, 67-74. [Google Scholar] [CrossRef] [PubMed]
[33] Cipolla-Neto, J., et al. (2014) Melatonin, Energy Metabolism, and Obesity: A Review. Journal of Pineal Research, 56, 371-381. [Google Scholar] [CrossRef] [PubMed]
[34] 孙平, 乔炳龙, 李超, 等. 褪黑素抑制氧化应激和铁死亡缓解妊娠糖尿病大鼠病理损伤[J]. 现代妇产科进展, 2021, 30(3): 171-176.
[35] Maciej, T., Damian, M., Krzysztof, S., et al. (2017) MTNR1A and MTNR1B Gene Polymorphisms in Women with Gestational Diabetes. Gynecological Endocrinology, 33, 395-398. [Google Scholar] [CrossRef] [PubMed]
[36] Liu, W., et al. (2020) Melatonin-Stimulated MSC-Derived Exosomes Improve Diabetic Wound Healing through Regulating Macrophage M1 and M2 Polarization by Targeting the PTEN/AKT Pathway. Stem Cell Research & Therapy, 11, Article No. 259. [Google Scholar] [CrossRef] [PubMed]
[37] 夏显, 漆洪波. 美国母胎医学会《妊娠期肝内胆汁淤积症指南(2020版)》解读[J]. 实用妇产科杂志, 2021, 37(8): 587-590.
[38] Jung, K.H., et al. (2009) Melatonin Downregu-lates Nuclear Erythroid 2-Related Factor 2 and Nuclear Factor-kappaB during Prevention of Oxidative Liver Injury in a Dimethylnitrosamine Model. Journal of Pineal Research, 47, 173-183. [Google Scholar] [CrossRef] 
[39] 孟宪红, 李立, 曹巍, 等. 褪黑素对非酒精性脂肪性肝病中NLRP3炎症小体和肝脏纤维化的影响及机制研究[J]. 哈尔滨医科大学学报, 2021, 55(5): 451-456.
[40] Li, Y.Z., et al. (2019) Melatonin Ameliorates ANIT-Induced Cholestasis by Activating Nrf2 through a PI3K/Akt-De- pen-dent Pathway in Rats. Molecular Medicine Reports, 19, 1185-1193.
[41] de Albuquerque, Y.M.L., et al. (2020) Melato-nin on Hypothyroidism and Gonadal Development in Rats: A Review. JBRA Assisted Reproduction, 24, 498-506.
[42] Skipor, J., Misztal, T. and Kaczmarek, M.M. (2010) Independent Changes of Thyroid Hormones in Blood Plasma and Cerebrospinal Fluid after Melatonin Treatment in Ewes. Theriogenology, 74, 236-245. [Google Scholar] [CrossRef] [PubMed]
[43] de Albuquerque, Y.M.L., et al. (2020) Effect of Melato-nin on Gonad and Thyroid Development of Offspring of Hypothyroid Pregnant Rats. Biotechnic & Histochemistry, 95, 522-531. [Google Scholar] [CrossRef] [PubMed]

为你推荐