化痰清肺汤联合西药治疗学龄前期儿童急性支气管炎(痰热壅肺证)的临床观察

Clinical Observation of Huatan Qingfei Decoction Combined with Western Medicine in the Treatment of Acute Bronchitis (Phlegm Heat Blocking Lung Syndrome) in Preschool Children

摘要: 研究化痰清肺汤联合西药治疗学龄前期儿童急性支气管炎痰热壅肺证的临床疗效。方法：采取前瞻性队列研究方法，选取2020年02月01日至2021年02月01日符合纳入标准患者108例作为观察对象，随机分为治疗组与对照组，治疗组54例，对照组54例。对照组采用西医常规治疗，治疗组在采用西医常规治疗的基础上加用化痰清肺汤加减治疗。观察此2组患儿治疗前及治疗1周后临床症状改善时间、中医症候积分的变化，以及副作用观察情况。结果：治疗7天后，治疗组总有效率96.30%，对照组总有效率83.33%，两者差距显著(P < 0.05)；治疗组发热、咳嗽、咳痰、肺部啰音等症状改善时间均较对照组明显缩短(P < 0.05)，具有统计学意义；两组患者的咳嗽症状积分较治疗前均有明显降低(P均 < 0.05)，经治疗后，治疗组咳嗽症候积分明显低于对照组(P < 0.05)，有统计学意义。观察期间两组均未发生与药物相关性腹痛、腹泻、皮疹、恶心、呕吐等不良反应。结论：中药化痰清肺汤联合西药治疗小儿急性支气管炎(痰热壅肺证)能有效改善患儿临床症状体征，疗效确切。

Abstract: Objective: To study the clinical efficacy of Huatan Qingfei Decoction Combined with western medicine in the treatment of phlegm heat blocking lung syndrome of acute bronchitis in preschool children. Methods: A prospective cohort study was conducted. 108 patients who met the inclusion criteria from February 1, 2020 to February 1, 2021 were randomly divided into treatment group and control group. There were 54 cases in the treatment group and 54 cases in the control group. The control group was treated with routine western medicine, and the treatment group was treated with Huatan Qingfei Decoction on the basis of routine western medicine. The improvement time of clinical symptoms, the change of TCM symptom score and the observation of side effects were observed before and 1 week after treatment. Results: After 7 days of treatment, the total effective rate of the treatment group was 96.30%, and the total effective rate of the control group was 83.33%. The difference between the two was significant (P < 0.05); the improvement time of symptoms such as fever, cough, expectoration, and pulmonary rales in the treatment group was significantly shorter than that in the control group (P < 0.05); with statistical significance; the cough symptom scores of the two groups were significantly lower than those before treatment (P < 0.05). The cough symptom score in the treatment group was significantly lower than that in the control group (P < 0.05), with statistical significance. During the observation period, no adverse reactions such as drug-related abdominal pain, diarrhea, rash, nausea and vomiting occurred in the two groups. Conclusion: Huatan Qingfei Decoction Combined with western medicine can effectively improve the clinical symptoms and signs of children with acute bronchitis (phlegm heat blocking lung syndrome).