施万细胞在皮肤疾病中的研究进展

Research Progress of Schwann Cells in Skin Diseases

摘要: 施万细胞(Schwann cells, SCs)长期以来被认为具有支持、修复和促进周围神经系统损伤后轴突再生的能力。在对神经损伤的反应中，它们迅速去分化成前体样状态，分泌一系列炎症介质和生长因子、增殖、经历上皮–间充质样转化以促进迁移、吞噬细胞碎片，并重塑细胞外环境以促进轴突通过损伤部位的再生。尽管施万细胞(Schwann cells, SCs)的皮肤作用越来越被认识，在本文中我们认为施万细胞(Schwann cells, SCs)在皮肤感觉和神经修复之外的皮肤生理学和病理学中，其可能的复杂功能值得更多的关注和系统研究。例如，促进/加速黑色素瘤的生长和侵袭、施万细胞(Schwann cells, SCs)促进伤口愈合、支持神经纤维瘤/神经鞘瘤的生长等。

Abstract: Schwann cells (SCs) have long been considered to have the ability to support, repair and promote axonal regeneration after peripheral nervous system injury. In response to nerve injury, they rap-idly dedifferentiate into precursor-like states, secrete a series of inflammatory mediators and growth factors, proliferate and undergo epithelial-mesenchymal transformation to promote migra-tion and phagocytosis of cell fragments, and reshape the extracellular environment to promote axon regeneration through the injured site. Although the skin function of SCs is more and more recog-nized, in this paper, we believe that the possible complex functions of SCs deserve more attention and systematic study in skin physiology and pathology besides skin sensory and nerve repair. For example, it promotes or accelerates the growth and invasion of melanoma, SCs promotes wound healing, and supports the growth of neurofibroma or schwannoma.