巨噬细胞极化调控炎症反应的研究进展
Research Progress in the Regulation of Inflammatory Response by Macrophage Polarization
DOI: 10.12677/ACM.2022.127980, PDF,   
作者: 彭毛东智:青海大学,青海 西宁
关键词: 巨噬细胞极化调控miRNAMacrophage Polarization Control miRNA
摘要: 巨噬细胞由单核吞噬细胞分化而来,在不同的组织部位可以分化成不同的表型、表现出不同的功能,在炎症发展早期,巨噬细胞通过经典途径分化成M1型,从而分泌各种促炎细胞因子,发挥创面抗感染的作用,炎症后期分化成M2型,分泌多种抗炎因子,控制局部炎症,从而影响创面愈合;因此,通过影响不同病理阶段巨噬细胞极化方向,从而控制炎症反应,达到治疗目的成为新的研究热点。
Abstract: Macrophages are derived from mononuclear phagocytes, can be divided into different phenotypesin in different tissue and show different functions. In the early development of inflammation, macro-phages through classic way to differentiate into M1, and secrete a variety of proinflammatory cyto-kines, play to the role of the resistance to infection, and in the later development of inflammation it differentiates into M2 type, secretes a variety of anti-inflammatory factor to control local inflamma-tion, thus affecting wound healing. Therefore, by influencing the polarization direction of macro-phages at different pathological stages, so as to control the inflammatory response and achieve the purpose of treatment has become a new research hotspot.
文章引用:彭毛东智. 巨噬细胞极化调控炎症反应的研究进展[J]. 临床医学进展, 2022, 12(7): 6796-6803. https://doi.org/10.12677/ACM.2022.127980

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