款冬花化学成分的研究
Study on Chemical Constituents of Tussilago farfara L.
DOI: 10.12677/PI.2022.114042, PDF,    科研立项经费支持
作者: 秦智彬, 张雨晨, 曹 青, 刘生元, 陈敏纯, 闫抗抗*：西北大学附属医院西安市第三医院药剂科，陕西 西安
关键词: 款冬花；倍半萜；化学成分；Tussilago farfara L.； Sesquiterpenoids； Chemical Constituents
摘要: 目的：研究款冬花中的化学成分。方法：综合应用反相色谱、Sephadex LH-20、液相和半制备液相等多种化学色谱方法进行分离纯化，并根据化合物的理化性质和核磁共振波谱进行结构鉴定。结果：从款冬花的95%乙醇提取物中分离得到20个化合物，通过波谱分析等手段鉴定了15个化合物，包括12个倍半萜，2个脂肪酸和1个生物碱。结论：化合物6和15为首次从款冬花中分离得到的。
Abstract: Objective: To study the constituents of Tussilago farfara L. Methods: The compounds were isolated and purified by column chromatography of Sephadex LH-20, HPLC and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results: By the means of chromatography methods and spectroscopic evidence, 20 compounds were isolated from 95% EtOH of T. farfara. We identified 15 compounds by spectroscopic analysis, 12 of which were sesquiterpenoids. Conclusion: Compounds 6 and 15 are identified from Tussilago farfara L. for the first time.
文章引用：秦智彬, 张雨晨, 曹青, 刘生元, 陈敏纯, 闫抗抗. 款冬花化学成分的研究[J]. 药物资讯, 2022, 11(4): 327-334. https://doi.org/10.12677/PI.2022.114042

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