基于高血压病症的富硒米定量补硒疗效初报

A Initial Report on the Efficacy of Selenium Enriched Rice in Quantitative Selenium Supplementation Based on Hypertension

摘要: 硒是人体必需的微量元素，具有提高人体免疫力、清除自由基、延缓衰老等重要生理功能，适量补硒对高血压具有预防与治疗的效果。本研究通过富硒大米定量补硒5年半，以参试者2010年12月至2022年5月期间的体检报告数据为依据进行分析，结果表明：1) 高血压患者在不使用降压药的情况下，通过富硒大米定量补硒可有效降低血压，5年半内SBP (收缩压)、DPB (舒张压)分别降低了23.5%、20.2%，降压效果显著。2) 补硒强度与降压效果呈正相关，总体表现为：150 μg/d > 100 μg/d > 50 μg/d。其中：富硒大米日补硒量与舒张压年均降低量呈极显著正相关(P = 0.01)，以日补硒150 μg的降压效果最佳；富硒大米日补硒量与收缩压年均降低量呈正相关，但未达到差异显著水平(P = 0.05)，以日补硒100~150 μg的降压效果较好。鉴于高血压发病率呈增长趋势的现状，建议以大米为主食的人群采用富硒大米进行定量补硒，健康成人日补硒60~100 μg，具有预防高血压的作用；1级高血压患者日补硒100~150 μg，具有良好的降压效果，且无需服用降压药；2级以上高血压患者需增大补硒强度，以日补硒200 μg左右为宜，对药物降压具有辅助治疗作用。

Abstract: Selenium is an essential trace element for human body. It has important physiological functions such as improving human immunity, eliminating free radicals and delaying aging. Appropriate selenium supplementation has the effect of prevention and treatment of hypertension. In this study, selenium enriched rice was used to quantitatively supplement selenium for 5 and a half years. Based on the physical examination report data of the participants from December 2010 to May 2022, the results showed that: 1) without antihypertensive drugs, selenium enriched rice could effectively reduce blood pressure. Within 5 and a half years, SBP (systolic blood pressure) and DPB (diastolic blood pressure) were reduced by 23.5% and 20.2% respectively, with significant antihy-pertensive effect. 2) The intensity of selenium supplement was positively correlated with the effect of blood pressure reduction, and the overall performance was: 150 μg/d > 100 μg/d > 50 μg/d. Among them, the daily selenium supplement amount of selenium rich rice is positively correlated with the annual decrease of diastolic blood pressure (p = 0.01), and the daily selenium supplement amount is 150 μG had the best antihypertensive effect; the daily selenium supplement amount of selenium rich rice was positively correlated with the annual decrease of systolic blood pressure, but did not reach the significant difference level (p = 0.05), and the daily selenium supplement amount was 100~150 μG has a good effect on reducing blood pressure. In view of the increasing incidence rate of hypertension, it is suggested that people who take rice as their staple food should use selenium rich rice for quantitative selenium supplement, and healthy adults should supplement 60~100 selenium per day μ g. It can prevent hypertension; daily selenium supplement for patients with grade 1 hypertension: 100~150 μg. It has good antihypertensive effect without taking antihy-pertensive drugs; patients with hypertension above grade 2 should increase the intensity of selenium supplement, and supplement selenium 200 per day μG is appropriate, which has an auxiliary therapeutic effect on drug hypotension.