关于阻塞性睡眠呼吸暂停综合征生物标志物的研究现状
Research Status on Biomarkers of Obstructive Sleep Apnea Syndrome
摘要: 阻塞性睡眠呼吸暂停综合征(OSAS)是一种复杂的慢性炎症性呼吸道疾病，具有多种致病因素，其主要临床表现是夜间睡眠时打鼾、呼吸及睡眠节律紊乱、反复出现呼吸暂停及觉醒，白天嗜睡、记忆力下降甚至认知行为障碍等。考虑到OSAS发病率和死亡率高，但诊断率和治疗率却很低的主要原因是目前国内外均采用多导睡眠监测(Polysomnography, PSG)来诊断OSAS，并以睡眠呼吸暂停低通气指数(AHI)及最低血氧饱和度(LSaO2)的分级来判定OSAS的严重程度。但是PSG的检查需要较多的人力资源和时间，作为判断病情严重程度较为复杂。因此，在血清中寻找一种简单、安全用于辅助PSG评估OSAHS严重程度和缺氧负担，以及监测治疗效果的生物标志物，将为睡眠呼吸暂停的研究和临床管理带来很大的进步。
Abstract: Obstructive sleep apnea syndrome (OSAS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors. Its main clinical manifestations are snoring, respiratory and sleep rhythm disorders, recurrent apnea and wakefulness, daytime sleepiness, memory decline and even cognitive and behavioral disorders. Considering that Polysomnography (PSG) is currently used to diagnose OSAS at home and abroad, the main reason for the low rate of diagnosis and treatment is the high incidence and mortality of OSAS. The severity of OSAS was determined by sleep apnea hy-popnea index (AHI) and lowest blood oxygen saturation (LSaO2). However, PSG examination re-quires more human resources and time, so it is complicated to judge the severity of the disease. Therefore, finding a simple and safe biomarker in serum to assist PSG in assessing the severity and hypoxia burden of OSAHS, as well as monitoring the therapeutic effect, will bring great progress to the research and clinical management of sleep apnea.
文章引用：马静, 李慧, 杜延玲. 关于阻塞性睡眠呼吸暂停综合征生物标志物的研究现状[J]. 临床医学进展, 2022, 12(8): 7059-7064. https://doi.org/10.12677/ACM.2022.1281016

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