代谢组学在棘球蚴病中的研究进展
Research Progress on the Application of Metabolomics in Alveolar Echinococcosis
摘要: 棘球蚴病是由多房棘球蚴侵染人类所致的一类极罕见的、威胁极大的人畜共患病症状，可出现在人身体的多种脏器，其中又以肝居多，极易误诊为肝癌，而中晚期的根治性手术困难度较大，且预后不好，死亡率也极高，对人有致死的危险因此又被称之为“虫癌”。代谢组学作为一种新兴学科，定义为生物体内对病理生理过程及基因修饰等因素影响下形成的代谢产物动力学应答的定性检测，目前已被普遍运用于胃癌、肝癌、胰腺癌等病症的检测研究中，而利用代谢组学分析得到的信息更有助于比较全面地揭示生物系统生理结构与生化功能状况。
Abstract: Alveolar echinococcosis is a rare and life-threatening zoonosis caused by multilocular echinococ-cosis infection. It can occur in multiple organs of the body, especially the liver, which is easily mis-diagnosed as liver cancer. Radical surgery is difficult, with poor prognosis and high mortality, which is also known as “worm cancer”. As an emerging discipline, metabolomics is defined as the quanti-tative determination of the dynamic response of organisms to the stimuli such as pathophysiology or gene modification. It has been widely used in the diagnosis of gastric cancer, liver cancer, pan-creatic cancer and other diseases. The information obtained through metabolomics research can more comprehensively reveal the physiological and biochemical function of the biological system.
文章引用：李剑, 侯立朝. 代谢组学在棘球蚴病中的研究进展[J]. 临床医学进展, 2022, 12(8): 7091-7096. https://doi.org/10.12677/ACM.2022.1281021

参考文献

[1] 韩秀敏, 王虎, 邱加闽, 马宵, 蔡辉霞, 刘培运, 丁启军, 代南, Ito, A., Craig, P.S. 青海省班玛地区泡型和囊类包虫病的传播情况研究与分析[J]. 全国人兽共患病报, 2006(2): 189-190.
[2] 韩秀敏, 张学勇, 蔡其刚, 张静妮, 王永顺, 张强. 贵州省南方高原藏族儿童泡型包虫病传播状况剖析[J]. 中华血吸虫病预防杂社, 2017, 29(1): 5358.
[3] Xi, B., Gu, H., Baniasadi, H. and Raftery, D. (2014) Statistical Analysis and Modeling of Mass Spectrome-try-Based Metabolomics Data. In: Raftery, D., Ed., Mass Spectrometry in Metabolomics, Vol. 1198, Humana Press, New York, 333-353. [Google Scholar] [CrossRef] [PubMed]
[4] Nicholson, J.K., Lindon, J.C. and Holmes, E. (1999) ‘Metabonomics’: Understanding the Metabolic Responses of Living Systems to Pathophysiological Stimuli via Multivariate Statistical Analysis of Biological NMR Spectroscopic Data. Xenobiotica, 29, 1181-1189. [Google Scholar] [CrossRef] [PubMed]
[5] Rochfort, S. (2005) Metabolomics Reviewed: A New “Omics” Platform Technology for Systems Biology and Implications for Natural Products Research. Journal of Natural Products, 68, 1813-1820. [Google Scholar] [CrossRef] [PubMed]
[6] Fiehn, O., Kopka, J., Dörmann, P., et al. (2000) Metabo-lite Profiling for Plant Functional Genomics. Nature Biotechnology, 18, 1157-1161. [Google Scholar] [CrossRef] [PubMed]
[7] Tang, H.R. and Wang, Y.L. (2006) Metabonomics: A Revolution in Progress. Progress in Biochemistry and Biophysics, 33, 401-407.
[8] Oh, J., Choi, E., Yoon, D.H., et al. (2019) 1H-NMR-Based Metabolic Profiling of Cordyceps Militaris to Correlate the Development Process and Anti-Cancer Effect. Journal of Mi-crobiology and Biotechnology, 29, 1212-1220. [Google Scholar] [CrossRef] [PubMed]
[9] Lario, S., Ramirez-Lazaro, M.J., Sanjuan-Herraez, D., et al. (2017) Plasma Sample Based Analysis of Gastric Cancer Propression Using Targeted Metabolomics. Scientific Reports, 7, Arti-cle No. 17774. [Google Scholar] [CrossRef] [PubMed]
[10] Kuligowski, J., Sanjuan-Herraez, D., Vazquez-Sanchez, M.A., et al. (2016) Metabolomic Analysis of Gastric Cancer Progression within the Correa’s Cascade Using Ultraperformance Liquid Chromatography Mass Spectrometry. Journal of Proteome Research, 15, 2729-2738. [Google Scholar] [CrossRef] [PubMed]
[11] Chetwynd, A.J. and David, A. (2018) A Review of Nanoscale LC-ESI for Metabolomics and Its Potential to Enhance the Metabolome Coverage. Talanta, 182, 380-390. [Google Scholar] [CrossRef] [PubMed]
[12] Dunn, W.B., Broadhurst, D., Begley, P., Zelena, E., Fran-cis-Mcintyre, S., Anderson, N., Brown, M., Knowles, J.D., Halsall, A., Haselden, J.N., Nicholls, A.W., Wilson, I.D., Kell, D.B. and Goodacre, R. (2011) Procedures for Large-Scale Metabolic Profiling of Serum and Plasma Using Gas Chromatography and Liquid Chromatography Coupled to Mass Spectrometry. Nature Protocols, 6, 1060-1083. [Google Scholar] [CrossRef] [PubMed]
[13] Wantej, M.P., Michopoulos, F., Wilson, I.D., Theodoridis, G., Plumb, R.S., Shockcor, J., Loftus, N., Holmes, E. and Nicholson, J.K. (2013) Global Metabolic Profiling of Animal and Human Tissues via UPLC-MS. Nature Protocols, 8, 17-32. [Google Scholar] [CrossRef] [PubMed]
[14] Want, E.J., Wil-son, I.D., Gika, H., Theodoridis, G., Plumb, R.S., Shockcor, J., Holmes, E. and Nicholson, J.K. (2010) Global Metabolic Profiling Procedures for Urine Using UPLC-MS. Nature Protocols, 5, 1005-1018. [Google Scholar] [CrossRef] [PubMed]
[15] Feng, J., Liu, H., Bhakoo, K.K., et al. (2011) A Metabonomic Analysis of Organ Specific Response to USPIO Administration. Biomaterials, 32, 6558-6569. [Google Scholar] [CrossRef] [PubMed]
[16] Gao, L., Wang, K., Zhang, N., et al. (2018) 1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (−)-5-Hydroxy-Equol against Hepatocellular Carcinoma Cells in Vitro. J Proteome Res, 17, 1833-1843. [Google Scholar] [CrossRef] [PubMed]
[17] Xu, F., Li, X., Niu, W., et al. (2019) Metabolomic Profiling on Rat Brain of Prenatal Malnutrition: Implicated for Oxidative Stress and Schizophrenia. Metabolic Brain Disease, 34, 1607-1613. [Google Scholar] [CrossRef] [PubMed]
[18] Ciftci, T.T., Yabanoglu-Ciftci, S., Akinci, E., et al. (2021) Metabolomic Profiling of Active and Inactive Liver Cystic Echinococcosis. Acta Tropica, 221, Article ID: 105985. [Google Scholar] [CrossRef] [PubMed]
[19] Lakshmanan, V., Rhee, K.Y., Wang, W., Yu, Y., Khafizov, K., Fiser, A., Wu, P., Ndir, O., Mboup, S., Ndiaye, D. and Daily, J.P. (2012) Metabolomic Analysis of Patient Plasma Yields Evidence of Plant-Like α-Linolenic Acid Metabolism in Plasmodium falciparum. Journal of Infectious Diseases, 206, 238-248 [Google Scholar] [CrossRef] [PubMed]
[20] Surowiec, I., Orikiiriza, J., Karlsson, E., et al. (2015) Metabolic Signature Profiling as a Diagnostic and Prognostic Tool in Pediatric Plasmodium falciparum Malaria. Open Forum Infectious Diseases, 2, ofv062. [Google Scholar] [CrossRef] [PubMed]
[21] Lin, C., Chen, Z., Zhang, L., et al. (2019) Deciphering the Metabolic Per-turbation in Hepatic Alveolar Echinococcosis: A 1h NMR-Based Metabolomics Study. Parasites & Vectors, 12, Article No. 300. [Google Scholar] [CrossRef] [PubMed]
[22] 宋戈. 肝泡型包虫病患者血清代谢组学研究[D]: [硕士学位论文]. 青海: 青海大学, 2017
[23] 刘强, 刘静. 肝细胞性肝癌相关分子信号通路的研究进展[J]. 世界华人消化杂志, 2014(1): 8.
[24] 张凤娟. 肝泡型包虫病患者尿液代谢组学研究[D]: [硕士学位论文]. 青海: 青海大学, 2017.
[25] Zhu, M., Du, X., Xu, H., Yang, S., Wang, C., Zhu, Y., Zhang, T. and Zhao, W. (2021) Metabolic Profiling of Liver and Faeces in Mice Infected with Echinococcosis. Parasites & Vectors, 14, Article No. 324. [Google Scholar] [CrossRef] [PubMed]
[26] 刘洋. 肝泡型包虫病患者胆汁代谢组学研究[D]: [硕士学位论文]. 青海: 青海大学, 2018
[27] Hashim Abdalla, M.S., Taylor-Robinson, S.D. and Sharif, A.W. (2011) Differ-ences in Phosphatidylcholine and Bile Acids in Bile from Egyptian and UK Patients with and without Cholangiocarcino-ma. HPB, 13, 385-390. [Google Scholar] [CrossRef] [PubMed]
[28] Novak, M., Hameed, N., Buist, R., et al. (1992) Metabo-lites of Alveolar Echinococcus as Determined by [31P]- and [1H]- Nuclear Magnetic Resonance Spectroscopy. Parasitol-ogy Research, 78, 665-670. [Google Scholar] [CrossRef] 
[29] 蔡其刚. 青南儿童棘球蚴病调查分析及AE免疫学诊断、代谢组学研究[D]: [博士学位论文]. 兰州: 甘肃农业大学, 2019.
[30] 陆强, 黄一红, 丛辉, 等. 肝细胞癌、肝硬化患者血清中代谢物组研究[J]. 分析化学, 2009, 37(2): 194-198.

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