急性肾损伤早期及预后标志物新进展
New Progress of Early and Prognostic Mark-ers of Acute Kidney Injury
DOI: 10.12677/ACM.2022.1281032, PDF,  被引量    科研立项经费支持
作者: 王白菊：济宁医学院临床医学院，山东 济宁；济宁医学院附属医院全科医学科，山东 济宁；刘 雷*, 王 娜：济宁医学院附属医院全科医学科，山东 济宁
关键词: 急性肾损伤；生物标志物；早期诊断；预后；Acute Kidney Injury； Biomarkers； Early Diagnosis； Prognostic
摘要: 急性肾损伤(Acute kidney disease, AKI)是一种发病率高、自然病程多样、预后不一的临床急危重症。目前，AKI检测的标准诊断工具仍然是血肌酐浓度和尿量。然而，其在早期诊断AKI和评判预后等方面存在不足，因此寻找并获得有潜力的AKI生物标志物可对临床实践有诸多帮助。一些新型AKI生物标志物，如趋化因子、血管紧张素原、骨桥蛋白等在评估AKI早期和预后方面具有应用前景。本综述总结了近年AKI的早期诊断及预后标记物方面的进展。
Abstract: Acute kidney injury (AKI) is a clinical emergency with a high incidence, diverse natural history and variable prognosis. At present, the standard diagnostic tools for AKI detection remain serum creat-inine concentration and urine output. However, it is insufficient in early diagnosis of AKI and evalu-ation of prognosis, so finding and obtaining potential biomarkers of AKI can be of great help to clin-ical practice. Some novel AKI biomarkers, such as chemokines, angiotensinogen, osteopontin, etc., have application prospects in assessing the early stage and prognosis of AKI. This review summa-rizes the recent progress in early diagnosis and prognostic markers of AKI.
文章引用：王白菊, 刘雷, 王娜. 急性肾损伤早期及预后标志物新进展[J]. 临床医学进展, 2022, 12(8): 7154-7160. https://doi.org/10.12677/ACM.2022.1281032

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