胃癌相关抑癌基因在肝转移中的研究现状及进展
Current Situation and Progress of Tumor-Suppressor Gene Related to Gastric Cancer in Liver Metastasis
DOI: 10.12677/ACM.2022.1281035, PDF,   
作者: 侯茂林:济宁医学院临床医学院,山东 济宁;张秋杰*:济宁市第一人民医院,山东 济宁
关键词: 胃癌肝转移抑癌基因分子机制Cancer of the Stomach Hepatic Metastasis Cancer Suppressor Genes Molecular Mechanisms
摘要: 胃癌相关抑癌基因在肝转移的发生发展过程中起到重要作用,本文简介了主要的相关抑癌基因及研究现状,对胃癌肝转移的研究和治疗具有重要意义。
Abstract: Gastric cancer related tumor suppressor genes play an important role in the development of liver metastasis. This article introduces the main related tumor suppressor genes and the current re-search situation.
文章引用:侯茂林, 张秋杰. 胃癌相关抑癌基因在肝转移中的研究现状及进展[J]. 临床医学进展, 2022, 12(8): 7172-7180. https://doi.org/10.12677/ACM.2022.1281035

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Razzak, M. (2014) Genetics: New Molecular Classification of Gastric Adenocarcinoma Proposed by the Cancer Genome Atlas. Nature Reviews Clinical Oncology, 11, 499. [Google Scholar] [CrossRef] [PubMed]
[3] Xiao, Y., Zhang, B. and Wu, Y. (2019) Prog-nostic Analysis and Liver Metastases Relevant Factors after Gastric and Hepatic Surgical Treatment in Gastric Cancer Pa-tients with Metachronous Liver Metastases: A Population-Based Study. Irish Journal of Medical Science, 188, 415-422. [Google Scholar] [CrossRef] [PubMed]
[4] Ranzani, G.N., Luinetti, O., Padovan, L.S., Calistri, D., Renault, B., Burrel, M., Amadori, D., Fiocca, R. and Solcia, E. (1995) p53 Gene Mutations and Protein Nuclear Accumulation Are Early Events in Intestinal Type Gastric Cancerbut Late Events in Diffuse Type. Cancer Epidemiology, Biomarkers & Prevention, 4, 223-231.
[5] Cancer Genome Atlas Research Network (2014) Comprehensive Molecular Characteriza-tion of Gastric Adenocarcinoma. Nature, 513, 202-209. [Google Scholar] [CrossRef] [PubMed]
[6] Ikari, N., Seriza-wa, A., Mitani, S., Yamamoto, M. and Furukawa, T. (2019) Near-Comprehensive Resequencing of Cancer-Associated Genes in Surgically Resected Metastatic Liver Tumors of Gastric Cancer. The American Journal of Pathology, 189, 784-796. [Google Scholar] [CrossRef] [PubMed]
[7] Duffy, M.J., Synnott, N.C., O’Grady, S. and Crown, J. (2022) Targeting p53 for the Treatment of Cancer. Seminars in Cancer Biology, 79, 58-67. [Google Scholar] [CrossRef] [PubMed]
[8] Ogawa, M., Maeda, K., Onoda, N., Chung, Y.S. and Sowa, M. (1997) Loss of p21WAF1/CIP1 Expression Correlates with Disease Progression in Gastric Carcinoma. British Journal of Cancer, 75, 1617-1620. [Google Scholar] [CrossRef] [PubMed]
[9] Che, X., Hokita, S., Natsugoe, S., Tanabe, G., Baba, M., Takao, S., Ku-roshima, K. and Aikou, T. (2000) p21 Expression Is a Prognostic Factor in Patients with p53-Negative Gastric Cancer. Cancer Letters, 148, 181-188. [Google Scholar] [CrossRef
[10] Kosaka, M., Kang, M.R., Yang, G. and Li, L.C. (2012) Tar-geted p21WAF1/CIP1 Activation by RNAa Inhibits Hepatocellular Carcinoma Cells. Nucleic Acid Therapeutics, 22, 335-343. [Google Scholar] [CrossRef] [PubMed]
[11] 王勇, 郭永连, 陈琳, 李国灏, 应诚诚, 程薇. dsP21-625通过激活P21基因表达抑制前列腺癌细胞的增殖[J]. 中国肿瘤生物治疗杂志, 2018, 25(1): 35-39.
[12] Janzen, V., Forkert, R., Fleming, H.E., Saito, Y., Waring, M.T., Dombkowski, D.M., Cheng, T., DePinho, R.A., Sharpless, N.E. and Scad-den, D.T. (2006) Stem-Cell Ageing Modified by the Cyclin-Dependent Kinase Inhibitor p16INK4a. Nature, 443, 421-426. [Google Scholar] [CrossRef] [PubMed]
[13] Guo, Q., Chen, M., Chen, Q., Xiao, G., Chen, Z., Wang, X. and Huang, Y. (2021) Silencing p53 Inhibits Interleukin 10-Induced Activated Hepatic Stellate Cell Senescence and Fibrotic Degra-dation in Vivo. Experimental Biology and Medicine, 246, 447-458. [Google Scholar] [CrossRef] [PubMed]
[14] Clark, J.C., Thomas, D.M., Choong, P.F. and Dass, C.R. (2007) RECK—A Newly Discovered Inhibitor of Metastasis with Prognostic Significance in Multiple Forms of Cancer. Cancer and Metastasis Reviews, 26, Article No. 675. [Google Scholar] [CrossRef] [PubMed]
[15] Dashek, R.J., Diaz, C.J., Chandrasekar, B. and Rector, R.S. (2022) A Mechanistic Role for RECK in the Regulation of Hepatocellular Inflammation. The FASEB Journal, 36, R4647.
[16] Song, S.Y., Son, H.J., Nam, E., Rhee, J.C. and Park, C. (2006) Expression of Rever-sion-Inducingcysteine-Rich Protein with Kazal Motifs (RECK) as a Prognostic Indicator in Gastric Cancer. European Journal of Cancer, 42, 101-108. [Google Scholar] [CrossRef] [PubMed]
[17] Ohta, S., Lai, E.W., Morris, J.C., Pang, A.L., Watanabe, M., Yazawa, H., Zhang, R., Green, J.E., Chan, W.Y., Sirajuddin, P., Taniguchi, S., Powers, J.F., Tischler, A.S. and Pacak, K. (2008) Metastasis-Associated Gene Expression Profile of Liver and Subcutaneous Lesions Derived from Mouse Pheo-chromocytoma Cells. Molecular Carcinogenesis, 47, 245-251. [Google Scholar] [CrossRef] [PubMed]
[18] Yoshida, Y., Yuki, K., Dan, S., Yamazaki, K. and Noda, M. (2022) Sup-pression of Tumor Metastasis by a RECK-Activating Small Molecule. Scientific Reports, 12, Article No. 2319. [Google Scholar] [CrossRef] [PubMed]
[19] Shen, J., Wang, B., Zhang, T., Zhu, N., Wang, Z., Jin, J., He, Y. and Hu, M. (2018) Suppression of Non-Small Cell Lung Cancer Growth and Metastasis by a Novel Small Molecular Activator of RECK. Cellular Physiology and Biochemistry, 45, 1807-1817. [Google Scholar] [CrossRef] [PubMed]
[20] Gong, L., Govan, J.M., Evans, E.B., Dai, H., Wang, E., Lee, S.W., Lin, H.K., Lazar, A.J., Mills, G.B. and Lin, S.Y. (2015) Nuclear PTEN Tumor-Suppressor Functions through Maintaining Heterochromatin Structure. Cell Cycle, 14, 2323-2332. [Google Scholar] [CrossRef] [PubMed]
[21] Breier, G., Grosser, M. and Rezaei, M. (2014) Endothelial Cadherins in Cancer. Cell and Tissue Research, 355, 523-527. [Google Scholar] [CrossRef] [PubMed]
[22] Hacker, U.T., Escalona-Espinosa, L., Consalvo, N., Goede, V., Schiffmann, L., Scherer, S.J., et al. (2016) Evaluation of Angiopoietin-2 as a Biomarker in Gastric Cancer: Results from the Randomised Phase III AVAGAST Trial. British Journal of Cancer, 114, 855-862. [Google Scholar] [CrossRef] [PubMed]
[23] Zheng, H., Takahashi, H., Murai, Y., Cui, Z., Nomoto, K., Tsuneyama, K. and Takano, Y. (2007) Low Expression of FHIT and PTEN Correlates with Malignancy of Gastric Carcinomas: Tis-sue-Array Findings. Applied Immunohistochemistry & Molecular Morphology, 15, 432-440. [Google Scholar] [CrossRef] [PubMed]
[24] Zhang, L.L., Liu, J., Lei, S., Zhang, J., Zhou, W. and Yu, H.G. (2014) PTEN Inhibits the Invasion and Metastasis of Gastric Cancer via Downregulation of FAK Expression. Cell Signal, 26, 1011-1020.
[25] Carter, W.B., Niu, G., Ward, M.D., Small, G., Hahn, J.E. and Muffly, B.J. (2007) Mecha-nisms of HER2-Induced Endothelial Cell Retraction. Annals of Surgical Oncology, 14, 2971-2978. [Google Scholar] [CrossRef] [PubMed]
[26] 洪华章, 周凯, 傅平, 黄琪, 王俊, 袁喜红, 等. 抑癌基因脾酪氨酸激酶和人类Runt相关转录因子3基因启动子甲基化与胃癌术后复发转移的关系[J]. 中华肿瘤杂志, 2014(5): 341-345.
[27] Qu, C., Zheng, D., Li, S., Liu, Y., Lidofsky, A., Holmes, J.A., et al. (2018) Tyrosine Kinase SYK Is a Potential Therapeutic Target for Liver Fibrosis. Hepatology, 68, 1125-1139. [Google Scholar] [CrossRef] [PubMed]
[28] Lombardi, D.P., Geradts, J., Foley, J.F., Chiao, C., Lamb, P.W. and Barrett, J.C. (1999) Loss of KAI1 Expression in Progression of Colorectal Cancer. Cancer Research, 59, 5724-5731.
[29] Guo, J., Fan, K.X., Xie, L.I., Xiao, J.J., Chen, K., Hui, L.N. and Xu, Z.F. (2015) Effect and Prognostic Significance of the KAI1 Gene in Human Gastric Carcinoma. Oncology Letters, 10, 2035-2042. [Google Scholar] [CrossRef] [PubMed]
[30] Yu, G., Chen, Y., Ni, C., Wang, G., Qian, J. and Wang, J. (2007) Re-duced Protein Expression of Metastasis-Related Genes (nm23, KISS1, KAI1 and p53) in Lymph Node and Liver Metas-tases of Gastric Cancer. International Journal of Experimental Pathology, 88, 175-183. [Google Scholar] [CrossRef] [PubMed]
[31] Zheng, H., Tsuneyama, K., Cheng, C., Takahashi, H., Cui, Z., Nomoto, K., Murai, Y. and Takano, Y. (2007) Expression of KAI1 and Tenascin, and Microvessel Density Are Closely Correlated with Liver Metastasis of Gastrointestinal Adenocarcinoma. Journal of Clinical Pathology, 60, 50-56. [Google Scholar] [CrossRef] [PubMed]
[32] 徐广敏, 龙艳丽. 去甲基化药物对胃癌细胞中KAI1基因表达水平影响初探[J]. 广东医学, 2017, 38(19): 2931-2933. [Google Scholar] [CrossRef
[33] 赵颖, 朱大兴, 陈晓禾, 朱文, 尤嘉琮, 李洋, 等. KAI1基因在人肺癌细胞株中的表达水平及调控机制的研究[C]//中国抗癌协会肺癌专业委员会. 第13届全国肺癌学术大会论文汇编. 长春: 中国抗癌协会, 2013: 382-384.
[34] 张捷, 陈晓华. KAI1在原发性肝癌组织中的表达水平及调控机制的初探[J]. 中国实验诊断学, 2003, 7(3): 234-237.
[35] 胡潇滨. Kiss-1基因抑制胃癌脏器转移的机制研究[D]: [博士学位论文]. 沈阳: 中国医科大学, 2018.
[36] Dhar, D.K., Naora, H., Kubota, H., Maruyama, R., Yoshimura, H., Tonomoto, Y., Tachibana, M., Ono, T., Otani, H. and Nagasue, N. (2004) Downregulation of KiSS-1 Expression Is Responsible for Tumor Invasion and Worse Prognosis in Gastric Carcinoma. International Journal of Cancer, 111, 868-872. [Google Scholar] [CrossRef] [PubMed]
[37] Beck, B.H. and Welch, D.R. (2010) The KISS1 Metastasis Suppressor: A Good Night Kiss for Disseminated Cancer Cells. European Journal of Cancer, 46, 1283-1289. [Google Scholar] [CrossRef] [PubMed]
[38] Tanaka, A., Nakata, D., Masaki, T., Kusaka, M., Watanabe, T. and Matsui, H. (2018) Evaluation of Pharmacokinetics/Pharmacodynamics and Efficacy of One-Month Depots of TAK-448 and TAK-683, Investigational Kisspeptin Analogs, in Male Rats and an Androgen-Dependent Prostate Cancer Model. European Journal of Pharmacology, 822, 138-146. [Google Scholar] [CrossRef] [PubMed]
[39] 姚乐, 李梅, 安毅. Tiam1和nm23H1在胃癌中的表达[J]. 中国医药指南, 2014(35): 21-22.
[40] 季斌斌. Ki67、nm23-H1在胃癌组织中的表达与肝转移的关系[D]: [硕士学位论文]. 包头: 内蒙古科技大学包头医学院, 2020.
[41] Nesi, G., Palli, D., Pernice, L.M., Saieva, C., Paglierani, M., Kroning, K.C., et al. (2001) Expression of nm23 Gene in Gastric Cancer Is Associated with a Poor 5-Year Survival. Anticancer Research, 21, 3643-3649.
[42] 王桂美, 张良明. nm23-H1和Livin表达对铂类化疗晚期胃癌预后影响[J]. 齐鲁医学杂志, 2010, 25(3): 210-213.
[43] Li, J., Zhou, J., Chen, G., Wang, H., Wang, S., Xing, H., Gao, Q., Lu, Y., He, Y. and Ma, D. (2006) Inhibition of Ovarian Cancer Metastasis by Adeno-Associated Virus-Mediated Gene Transfer of nm23H1 in an Orthotopic Implantation Model. Cancer Gene Ther-apy, 13, 266-272. [Google Scholar] [CrossRef] [PubMed]
[44] Lim, J., Jang, G., Kang, S., Lee, G., Nga do, T.T., Phuong do, T.L., et al. (2011) Cell-Permeable NM23 Blocks the Maintenance and Progression of Establis hed Pulmo-nary Metastasis. Cancer Research, 71, 7216-7225. [Google Scholar] [CrossRef
[45] Miller, K.D., Althouse, S.K., Nabell, L., Rugo, H., Carey, L., Kimmick, G., Jones, D.R., Merino, M.J. and Steeg, P.S. (2014) A Phase II Study of Medroxyprogesterone Acetate in Patients with Hormone Receptor Negative Metastatic Breast Cancer: Translational Breast Cancer Research Consortium Trial 007. Breast Cancer Research and Treatment, 148, 99-106. [Google Scholar] [CrossRef] [PubMed]
[46] Kim, B. and Lee, K.J. (2021) Activation of nm23-H1 to Suppress Breast Cancer Metastasis via Redox Regulation. Experimental & Molecular Medicine, 53, 346-357. [Google Scholar] [CrossRef] [PubMed]
[47] Huang, Y., Yang, M., Hu, H., Zhao, X., Bao, L., Huang, D., Song, L. and Li, Y. (2016) Mitochondrial GRIM-19 as a Potential Therapeutic Target for STAT3-Dependent Carcino-genesis of Gastric Cancer. Oncotarget, 7, 41404-41420. [Google Scholar] [CrossRef] [PubMed]
[48] Huang, Y., Yang, M., Yang, H. and Zeng, Z. (2010) Upregulation of the GRIM-19 Gene Suppresses Invasion and Metastasis of Human Gastric Cancer SGC-7901 Cell Line. Experimental Cell Research, 316, 2061-2070. [Google Scholar] [CrossRef] [PubMed]
[49] 王欣. 线粒体GRIM-19缺失经ROS-NRF2-HO-1途径调控胃癌转移作用与机制[D]: [硕士学位论文]. 重庆: 重庆医科大学, 2020.[CrossRef
[50] Xu, Y., Wang, X., Guo, B., Wang, D., Kalvakolanu, D.V., Chen, X., Tang, J., Zhang, L. and Yang, Q. (2019) Nonviral Delivery of GRIM-19 Gene Inhibits Tumor Growth with Reduced Local and Systemic Complications. Human Gene Therapy, 30, 1419-1430. [Google Scholar] [CrossRef] [PubMed]