中医药调节肠道菌群治疗克罗恩病的研究进展

Research Progress of Traditional Chinese Medicine in Regulating Intestinal Flora in the Treatment of Crohn’s Disease

摘要: 克罗恩病(Crohn’s disease, CD)目前多使用柳氮磺砒啶、美沙拉嗪、泼尼松、英夫利昔单抗等药物维持治疗，严重者采取病变肠段切除的手术方式，但以上治疗仍存在复发率高和无法彻底治愈的缺点。近年来，越来越多的研究表明肠道菌群在炎症性肠病(inflammatory bowel disease, IBD)的发病过程中起到关键作用，肠道菌群的失衡会引发IBD。然而随着中药复方和针灸对CD的治疗和缓解作用逐步得到认可，笔者综合性分析了近年来对CD有治疗和缓解作用的中医药治法与肠道菌群的相关性，为进一步探索中医药调节肠道菌群治疗CD的免疫调节机制奠定基础，为中医药治疗和缓解CD的研究提供新的方向。

Abstract: At present, Crohn’s disease (Crohn’s disease, CD) is often treated with sulfasalazine, mesalazine, prednisone, infliximab and other drugs. In severe cases, resection of the diseased intestine is adopted, but the above treatment still has the disadvantages of high recurrence rate and cannot be completely cured. In recent years, more and more studies have shown that intestinal flora plays a key role in the pathogenesis of inflammatory bowel disease (inflammatory bowel disease, IBD), and the imbalance of intestinal flora will lead to IBD. However, with the gradual recognition of the ther-apeutic and palliative effects of traditional Chinese medicine and acupuncture on CD, the author comprehensively analyzed the correlation between the therapeutic and palliative effects of tradi-tional Chinese medicine on CD and intestinal flora in recent years, laying a foundation for further exploring the immunomodulatory mechanism of traditional Chinese medicine regulating intestinal flora in the treatment of CD, and providing a new direction for the research of traditional Chinese medicine in the treatment and mitigation of CD.