慢性乙型肝炎患者肝脏脂肪变性无创诊断方法的研究进展

Research Progress of Non-Invasive Diagnostic Methods for Hepatic Steatosis in Patients with Chronic Hepatitis B

摘要: 乙型肝炎病毒(HBV)感染是一个严重的全球性公共卫生问题，是导致全球肝硬化和肝细胞癌的主要病因。随着肥胖和代谢综合征的全球流行，非酒精性脂肪性肝病(NAFLD)成为西方和东方人群中慢性肝病的主要原因。HBV感染与NAFLD并存已成为肝病的普遍现象。肝脏脂肪变性的存在会影响慢性乙肝患者抗病毒治疗的效果，并增加发展为肝硬化和肝细胞癌的风险。因此，检测和量化肝脏脂肪变性对慢性乙肝的诊疗具有重要的意义。肝活检是评估肝脂肪变性的金标准，但由于其侵袭性和并发症的限制，并未在临床得到广泛应用。所以，慢性乙型肝炎患者肝脏脂肪变性的无创诊断就显得尤为重要，该文总结了慢性乙型肝炎患者合并肝脏脂肪变性无创诊断方法的研究进展。

Abstract: Hepatitis B virus (HBV) infection is a serious global public health problem and the main cause of liver cirrhosis and hepatocellular carcinoma in the world. With the global prevalence of obesity and metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) has become the main cause of chron-ic liver disease in western and eastern populations. The coexistence of HBV infection and NAFLD has become a common phenomenon of liver disease. The presence of hepatic steatosis affects the effica-cy of antiviral therapy in patients with chronic hepatitis B and increases the risk of developing cir-rhosis and hepatocellular carcinoma. Therefore, the detection and quantification of hepatic steato-sis is of great significance for the diagnosis and treatment of chronic hepatitis B. Liver biopsy is the gold standard for the evaluation of hepatic steatosis, but it has not been widely used in clinic be-cause of its invasiveness and complications. Therefore, the non-invasive diagnosis of hepatic steato-sis in patients with chronic hepatitis B is particularly important. This paper summarizes the re-search progress of non-invasive diagnosis of hepatic steatosis in patients with chronic hepatitis B.