GATA4基因表达调控在心肌肥厚和心力衰竭中的研究进展
Research Progress on the Correlation and Molecular Mechanism of GATA4 Gene Expression Regulation and Heart Failure
DOI: 10.12677/ACM.2022.1281089, PDF,   
作者: 郝文跃:济宁医学院临床医学院,山东 济宁;崔英华*:济宁医学院附属医院心内科,山东 济宁
关键词: 心力衰竭心肌肥厚GATA4Heart Failure Cardiac Hypertrophy GATA4
摘要: 心肌肥厚(Cardiac hypertrophy, CH)是心力衰竭(Heart failure, HF)前的重要病理改变,其具体机制的研究对心衰的治疗和预防有着重要的意义。GATA4是转录因子GATA家族的重要一员,目前研究已经证实,它对心肌肥厚的进程有着重要的影响。本文主要综述转录因子GATA4在CH和HF进程中调节机制的研究进展。
Abstract: Cardiac hypertrophy (CH) is an important pathological change before Heart failure (HF), and the study of its specific mechanism is of great significance for the treatment and prevention of Heart failure. GATA4 is an important member of the GATA family of transcription factors, and it has been confirmed that GATA4 plays an important role in the process of cardiac hypertrophy. This review focuses on the regulatory mechanism of GATA4 in CH and HF processes.
文章引用:郝文跃, 崔英华. GATA4基因表达调控在心肌肥厚和心力衰竭中的研究进展[J]. 临床医学进展, 2022, 12(8): 7546-7551. https://doi.org/10.12677/ACM.2022.1281089

参考文献

[1] Liu, Y., Zhang, Q., Yang, L., et al. (2022) Metformin Attenuates Cardiac Hypertrophy via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats. Frontiers in Pharmacology, 13, Article ID: 919202. [Google Scholar] [CrossRef] [PubMed]
[2] Nakamura, M. and Sadoshima, J. (2018) Mechanisms of Physio-logical and Pathological Cardiac Hypertrophy. Nature Reviews Cardiology, 15, 387-407. [Google Scholar] [CrossRef] [PubMed]
[3] Tsao, C.W., Aday, A.W., Almarzooq, Z.I., et al. (2022) Heart Disease and Stroke Statistics-2022 Update: A Report from the American Heart Association. Circulation, 145, e153-e639. [Google Scholar] [CrossRef
[4] Kim, G.H., Uriel, N. and Burkhoff, D. (2018) Reverse Re-modelling and Myocardial Recovery in Heart Failure. Nature Reviews Cardiology, 15, 83-96. [Google Scholar] [CrossRef] [PubMed]
[5] Whitcomb, J., Gharibeh, L. and Nemer, M. (2019) From Embryo-genesis to Adulthood: Critical Role for GATA Factors in Heart Development and Function. IUBMB Life, 72, 53-67. [Google Scholar] [CrossRef] [PubMed]
[6] Lentjes, M.H., Niessen, H., Akiyama, Y., et al. (2016) The Emerging Role of GATA Transcription Factors in Development and Disease. Expert Reviews in Molecular Medicine, 18, e3. [Google Scholar] [CrossRef] [PubMed]
[7] Floriani, M.A., Glaeser, A.B., Dorfman, L.E., et al. (2021) GATA 4 Dele-tions Associated with Congenital Heart Diseases in South Brazil. Journal of Pediatric Genetics, 10, 92-97. [Google Scholar] [CrossRef] [PubMed]
[8] Tong, Y.-F. (2016) Mutations of NKX2.5 and GATA4 Genes in the Development of Congenital Heart Disease. Gene, 588, 86-94. [Google Scholar] [CrossRef] [PubMed]
[9] Katanasaka, Y., Suzuki, H., Sunagawa, Y., et al. (2016) Regulation of Cardiac Transcription Factor GATA4 by Post-Translational Modification in Cardiomyocyte Hypertrophy and Heart Failure. International Heart Journal, 57, 672-675. [Google Scholar] [CrossRef] [PubMed]
[10] Valimaki, M.J. and Ruskoaho, H.J. (2020) Targeting GATA4 for Cardiac Repair. IUBMB Life, 72, 68-79. [Google Scholar] [CrossRef] [PubMed]
[11] Zhou, P., He, A. and Pu, W.T. (2012) Regulation of GATA4 Transcriptional Activity in Cardiovascular Development and Disease. Current Topics in Developmental Biology, 100, 143-169. [Google Scholar] [CrossRef
[12] Takaya, T., Kawamura, T., Morimoto, T., et al. (2008) Identification of p300-Targeted Acetylated Residues in GATA4 during Hypertrophic Responses in Cardiac Myocytes. Journal of Biological Chemistry, 283, 9828-9835. [Google Scholar] [CrossRef
[13] You, W., Song, L. and Wang, K. (2018) Acetylation of GATA4 on Lysine Residue K313 Promotes Osteoblastic Cells Growth. Cellular Physiology and Biochemistry, 46, 269-278. [Google Scholar] [CrossRef] [PubMed]
[14] Zhou, W., Jiang, D., Tian, J., et al. (2018) Acetylation of H3K4, H3K9, and H3K27 Mediated by p300 Regulates the Expression of GATA4 in Cardiocytes. Genes and Diseases, 6, 318-325. [Google Scholar] [CrossRef] [PubMed]
[15] Yamamura, S., Izumiya, Y., Araki, S., et al. (2020) Cardiomyo-cyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting with and Deacetylating GATA4. Hypertension, 75, 98-108. [Google Scholar] [CrossRef
[16] Rose, B.A., Force, T. and Wang, Y. (2010) Mi-togen-Activated Protein Kinase Signaling in the Heart: Angels versus Demons in a Heart-Breaking Tale. Physiological Reviews, 90, 1507-1546. [Google Scholar] [CrossRef] [PubMed]
[17] Liang, Q., Wiese, R.J., Bueno, O.F., et al. (2001) The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes. Molecular and Cellular Biology, 21, 7460-7469. [Google Scholar] [CrossRef
[18] Berlo, J., Elrod, J.W., Aronow, B.J., et al. (2011) Serine 105 Phosphorylation of Transcription Factor GATA4 Is Necessary for Stress-Induced Cardiac Hypertrophy in Vivo. Proceedings of the National Academy of Sciences of the United States of America, 108, 12331-12336. [Google Scholar] [CrossRef] [PubMed]
[19] Acosta, A.J., Rysa, J., Szabo, Z., et al. (2020) Phosphorylation of GATA4 at Serine 105 Is Required for Left Ventricular Remodelling Process in Angiotensin II-Induced Hypertension in Rats. Basic & Clinical Pharmacology & Toxicology, 127, 178-195. [Google Scholar] [CrossRef] [PubMed]
[20] Valimaki, M.J., Tolli, M.A., Kinnunen, S.M., et al. (2017) Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. Journal of Medicinal Chemistry, 60, 7781-7798. [Google Scholar] [CrossRef] [PubMed]
[21] Kinnunen, S.M., Tolli, M., Valimaki, M.J., et al. (2018) Car-diac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction. Scientific Reports, 8, Article No. 4611. [Google Scholar] [CrossRef] [PubMed]
[22] Karhu, S.T., Kinnunen, S.M., Tlli, M., et al. (2020) GATA4-Targeted Compound Exhibits Cardioprotective Actions against Doxorubicin-Induced Toxicity in Vitro and in Vivo: Establishment of a Chronic Cardiotoxicity Model Using Human iPSC-Derived Cardiomyocytes. Archives of Toxi-cology, 94, 2113-2130. [Google Scholar] [CrossRef] [PubMed]
[23] Vlimki, M.J., Leigh, R.S., Kinnunen, S., et al. (2021) GATA-Targeted Compounds Modulate Cardiac Subtype Cell Differentiation in Dual Reporter Stem Cell Line. Stem Cell Research & Therapy, 12, 190. [Google Scholar] [CrossRef] [PubMed]
[24] Han, P., Hang, C.T., Yang, J., et al. (2011) Chromatin Remod-eling in Cardiovascular Development and Physiology. Circulation Research, 108, 378-396. [Google Scholar] [CrossRef
[25] Mehta, G., Kumarasamy, S., Wu, J., et al. (2015) MITF Interacts with the SWI/SNF Subunit, BRG1, to Promote GATA4 Expression in Cardiac Hypertrophy. Journal of Molec-ular and Cellular Cardiology, 88, 101-110. [Google Scholar] [CrossRef] [PubMed]
[26] Van Berlo, J.H. (2015) Chromatin Remodeling Permits Cardiac Hypertrophy to Develop. Journal of Molecular and Cellular Cardiology, 89, 119-121. [Google Scholar] [CrossRef] [PubMed]
[27] Hota, S.K., Johnson, J.R., Verschueren, E., et al. (2019) Dynamic BAF Chromatin Remodeling Complex Subunit Inclusion Promotes Temporally Distinct Gene Expression Programs in Cardiogenesis. Development, 146, dev174086. [Google Scholar] [CrossRef] [PubMed]
[28] Sun, X., Hota, S.K., Zhou, Y.Q., et al. (2018) Cardiac-Enriched BAF Chromatin-Remodeling Complex Subunit Baf60c Regulates Gene Expression Programs Essential for Heart Development and Function. Biology Open, 7, bio.029512. [Google Scholar] [CrossRef] [PubMed]
[29] Iyer, L.M., Nagarajan, S., Woelfer, M., et al. (2018) A Context-Specific Cardiac Beta-Catenin and GATA4 Interaction Influences TCF7L2 Occupancy and Remodels Chromatin Driving Disease Progression in the Adult Heart. Nucleic Acids Research, 46, 2850-2867. [Google Scholar] [CrossRef] [PubMed]
[30] Shimizu, S., Sunagawa, Y., Hajika, N., et al. (2022) Multimerization of the GATA4 Transcription Factor Regulates Transcriptional Activity and Cardiomyocyte Hypertrophic Response. Interna-tional Journal of Biological Sciences, 18, 1079-1095. [Google Scholar] [CrossRef] [PubMed]