Npn2与其细胞因子VEGF、Sema3F的相关性
Correlation between Npn2 and Its Cytokines VEGF and Sema3F
DOI: 10.12677/ACM.2022.1281091, PDF,   
作者: 吕 婷, 杨光路*：内蒙古医科大学，内蒙古 呼和浩特
关键词: 血管内皮生长因子；VEGF；Npn2；Sema3F；Vascular Endothelial Growth Factor； VEGF； Npn2； Sema3F
摘要: 血管内皮生长因子(vascular endothelial growth factor, VEGF)是一个家族，包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和胎盘生长因子。神经毡蛋白(Neuropilin, Npn)是一类分子量为120~140 KD的I型跨膜蛋白，可参与机体的一系列生理和病理过程。信号素蛋白(Semaphorin Proteins, SIMAs)最初被认为是神经发育过程中排斥和吸引的神经引导线索。Npn2与其细胞因子VEGF、Sema3F参与多种中枢神经系统疾病，本文主要探讨其三者各自的功能及其关系。
Abstract: Vascular endothelial growth factor (vascular endothelial growth factor, VEGF) is a family that in-cludes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and placental growth factor. Neurofelt protein (Neuropilin, Npn) is a type I transmembrane protein with molecular weight of 120~140 KD, which can participate in a series of physiological and pathological processes. The signaling proteins (Sem-aphorin Proteins, SIMAs) were originally thought to be neuro-guiding cues of rejection and attrac-tion during neural development. Npn2 and its cytokines VEGF and Sema3F are involved in a variety of central nervous system diseases.
文章引用：吕婷, 杨光路. Npn2与其细胞因子VEGF、Sema3F的相关性[J]. 临床医学进展, 2022, 12(8): 7559-7563. https://doi.org/10.12677/ACM.2022.1281091

参考文献

[1] Wang, P., Sui, H.-J., Li, Xi.-J., Bai, L.-N., Bi, J. and Lai, H. (2021) Melatonin Ameliorates Microvessel Abnormalities in the Cerebral Cortex and Hippocampus in a Rat Model of Alzheimer’s Disease. Neural Regeneration Research, 16, 787-794. [Google Scholar] [CrossRef] [PubMed]
[2] Angelika, B., Michael, F., Martina, R., et al. (2019) Neuropilin-2 Is an Independent Prognostic Factor for Shorter Cancer-Specific Survival in Patients with Acinar Adeno-carcinoma of the Prostate. International Journal of Cancer, 146, 2619-2627. [Google Scholar] [CrossRef] [PubMed]
[3] Mitchell, S., Chiu, S.-L., Ginty, D.D., et al. (2017) Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron, 96, 1084-1098. [Google Scholar] [CrossRef] [PubMed]
[4] 文思思. 神经纤毛蛋白及其配体的免疫调节机制[J]. 国际输血及血液学杂志, 2015, 38(2): 178-181. [Google Scholar] [CrossRef] 
[5] Gerstmann, K., Kindbeiter, K., Telley, L., Bozon, M., Charoy, C., Jabaudon, D., Moret, F. and Castellani, V. (2020) An Unconventional Cerebrospinal Fluid-Derived Semaphorin-Signalling Regulates Apical Progenitor Dynamics in the Developing Neocortex.
[6] Lumb, R., Buckberry, S., Secker, G., et al. (2017) Transcriptome Profiling Reveals Expression Signatures of Cranial Neural Crest Cells Arising from Different Axial Levels. BMC Developmental Biology, 17, Article No. 5. [Google Scholar] [CrossRef] [PubMed]
[7] Sun, Y., Liegl, R., Gong, Y., et al. (2017) Sema3f Protects against Subretinal Neovascularization in Vivo. EBioMedicine, 18, 281-287. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, Q., Chiu, S.-L., Koropouli, E., et al. (2017) Neuro-pilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron, 96, 1084-1098.e7. [Google Scholar] [CrossRef] [PubMed]
[9] Kim, J.-E. and Kang, T.-C. (2017) TRPC3- and ET(B) Recep-tor-Mediated PI3K/AKT Activation Induces Vasogenic Edema Formation Following Status Epilepticus. Brain Research, 1672, 58-64. [Google Scholar] [CrossRef] [PubMed]
[10] Weis, S.M. and Cheresh, D.A. (2005) Pathophysiological Consequences of VEGF-Induced Vascular Permeability. Nature, 437, 497-504. [Google Scholar] [CrossRef] [PubMed]
[11] Belagodu, A.P., Fleming, S. and Galvez, R. (2017) Neocortical Devel-opmental Analysis of Vasculature and Their Growth Factors Offer New Insight into Fragile X Syndrome Abnormalities. Developmental Neurobiology, 77, 1321-1333. [Google Scholar] [CrossRef] [PubMed]
[12] Pignata, A., Ducuing, H., Boubakar, L., et al. (2019) A Spatiotemporal Sequence of Sensitization to Slits and Semaphorins Orchestrates Commissural Axon Navigation. Cell Reports, 29, 347-362.e5. [Google Scholar] [CrossRef] [PubMed]
[13] Bollard, J., Patte, C., Radkova, K., Massoma, P., Chardon, L., Valantin, J., Roche, C., et al. (2019) Neuropilin-2 Contributes to Tumor Progression in Preclinical Models of Small In-testinal Neuroendocrine Tumors. The Journal of Pathology, 249, 343-355. [Google Scholar] [CrossRef] [PubMed]
[14] Yang, J.-Y., Li, Y., Wang, Q., et al. (2020) MicroRNA-145 Suppresses Uveal Melanoma Angiogenesis and Growth by Targeting Neuroblastoma RAS Viral Oncogene Homolog and Vascular Endothelial Growth Factor. Chinese Medical Journal, 133, 1922-1929. [Google Scholar] [CrossRef] 
[15] Shen, J.K., Samul, R., Zimmer, J., et al. (2004) Deficiency of Neuropilin 2 Suppresses VEGF-Induced Retinal Neovascularization. Molecular Medicine, 10, 12-18. [Google Scholar] [CrossRef] 
[16] Maxime, A., Edward, M., Carol, E., et al. (2019) Neuropilin 2 Signaling Mediates Corticostriatal Transmission, Spine Maintenance, and Goal-Directed Learning in Mice. The Journal of Neuroscience, 39, 8845-8859. [Google Scholar] [CrossRef] 

为你推荐