探究唑吡坦与右佐匹克隆治疗卒中后睡眠障碍临床疗效

To Investigate the Clinical Efficacy of Zolpidem and Dexzopiclone in the Treatment of Sleep Disorders after Stroke

摘要: 目的：探究唑吡坦与右佐匹克隆治疗卒中后睡眠障碍的临床疗效。方法：在大理大学第一附属医院神经内科筛选106名符合条件的急性脑卒中合并睡眠障碍患者作为样本，样本收集时间为2021年1月~2022年1月。通过随机数字表方法分为2小组，每组各有53人，在常规治疗脑卒中的基础上，分别予以酒石酸唑吡坦片(对照组)和右佐匹克隆片(实验组)治疗，分析和对比2组间治疗后的临床效果。结果：经治疗，2组患者睡眠功能评分、NIHSS评分均有下降，但治疗前后2组患者间的睡眠功能评分、NIHSS评分比较差异无显著性(P > 0.05)；经过一周的治疗后，对照组的治疗总有效率为(78.28%)，而实验组的治疗总有效率(86.78%)明显更高，组间差异显著(P < 0.05)；经一周的治疗后，2组均有少量不良事件发生，实验组总不良事件发生率为3.78％，对照组总不良事件发生率为13.22%，组间差异性显著(P < 0.05)。结论：唑吡坦和右佐匹克隆治疗卒中后睡眠障碍均有效，但后者安全性更好，应用价值更高。

Abstract: Objective: To explore the clinical efficacy of zolpidem and dextrose zopiclone in the treatment of post-stroke sleep disorders. Methods: 106 eligible patients with acute stroke complicated with sleep disorders were selected as samples in the Department of Neurology, the First Affiliated Hospital of Dali University. The samples were collected from January 2021 to January 2022. Through the method of random number table, they were divided into two groups, with 53 people in each group. On the basis of routine treatment of stroke, they were treated with zolpidem tartrate tablets (control group) and dexzopiclon tablets (experimental group) respectively. The clinical effects after treatment between the two groups were analyzed and compared. Results: After treatment, the sleep function score and NIHSS score of the two groups decreased, but there was no significant difference between the two groups before and after treatment (P > 0.05); After a week of treatment, the total effective rate of the control group was (78.28%), while the total effective rate of the experimental group was significantly higher (86.78%), and the difference between groups was significant (P < 0.05); After a week of treatment, a small number of adverse events occurred in both groups. The total incidence of adverse events in the experimental group was 3.78%, and that in the control group was 13.22%. There was significant difference between the groups (P < 0.05). Conclusion: Both zolpidem and dexzopiclone are effective in the treatment of post-stroke sleep disorders, but the latter is safer and more valuable.