环状RNA在急性髓系白血病中的研究进展
Research Progress of CircRNAs in Acute My-eloid Leukemia
DOI: 10.12677/ACM.2022.1281134, PDF,   
作者: 寇丹婷, 葛繁梅*：延安大学附属医院，陕西 延安
关键词: 环状RNA；急性髓细胞性白血病；综述；Circular RNA； Acute Myeloid Leukemia； Review
摘要: 急性髓系白血病(AML)是起源于造血系统髓系原始细胞的克隆性恶性疾病。AML具有治愈率与存活率低而复发率高的特点，因此寻找早期且敏感的生物标记物、探索积极有效的治疗手段尤为重要。环状RNA (circRNA)是一类非编码RNA，可以在转录水平、转录后水平和表观遗传学等方面发挥重要的调控作用，影响细胞的增殖、分化、凋亡和耐药等生物学过程。本文就hsa-circ-0004277、circPAN3、hsa-circ-0009910、hsa-circ-0006332、hsa-circ-0017639等近几年来发现的circRNA在急性髓系白血病中的作用作一综述，旨在为AML的临床诊断及治疗靶点提供潜在依据。
Abstract: Acute myeloid leukemia (AML) is a clonal malignant disease originating from myeloid blasts of hematopoietic system. AML is characterized by low cure rate and survival rate and high recurrence rate. Therefore, it is particularly important to find early and sensitive biomarkers and explore ac-tive and effective treatment methods. Circular RNA (circRNA) is a class of non-coding RNA, which can play an important regulatory role in transcriptional level, post-transcriptional level and epige-netics, affecting biological processes such as cell proliferation, differentiation, apoptosis and drug resistance. This article reviews the role of circRNAs discovered in recent years, such as HSA-CIRC-0004277, circPAN3, HSA-CIRC-0009910, HSA-CIRC-0006332, HSA-CIRC-0017639 in acute myeloid leukemia, aiming to provide a potential basis for the clinical diagnosis and therapeutic targets of AML.
文章引用：寇丹婷, 葛繁梅. 环状RNA在急性髓系白血病中的研究进展[J]. 临床医学进展, 2022, 12(8): 7871-7876. https://doi.org/10.12677/ACM.2022.1281134

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