表观遗传学治疗在急性髓系白血病中的研究进展
Research Progress of Epigenetic Therapy in Acute Myeloid Leukemia
DOI: 10.12677/ACM.2022.1281152, PDF,   
作者: 杨香会, 付 滕, 张海亚:潍坊医学院临床医学院,山东 潍坊;王彦丽, 李 丽, 接贵涛*:临沂市中心医院血液科,山东 临沂
关键词: 急性髓系白血病表观遗传学修饰分子靶向治疗Acute Myeloid Leukemia Epigenetic Modification Molecular Targeted Therapy
摘要: 急性髓系白血病(acute myeloid leukemia, AML)是一种高度异质性的血液系统恶性肿瘤,为造血干细胞的克隆性疾病。近年来,随着对表观遗传学机制及分子靶向药物的深入研究和临床应用,AML个体精准化治疗水平明显提高,对于无法耐受强化治疗和复发难治性AML患者提供了新的治疗策略。该文对在急性髓系白血病中表观遗传学治疗药物的最新研究进展进行了综述。
Abstract: Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy, which is a clonal disease of hematopoietic stem cells. In recent years, with the in-depth research and clinical application of epigenetic mechanisms and molecular targeted drugs, the level of individual targeted treatment of AML has been significantly improved, providing a new treatment strategy for patients who cannot tolerate intensive treatment and relapsed refractory AML. This article reviews the lat-est research progress of epigenetic drugs in acute myeloid leukemia.
文章引用:杨香会, 付滕, 张海亚, 王彦丽, 李丽, 接贵涛. 表观遗传学治疗在急性髓系白血病中的研究进展[J]. 临床医学进展, 2022, 12(8): 8001-8007. https://doi.org/10.12677/ACM.2022.1281152

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