氧疗在慢性心力衰竭治疗中的研究进展
Research Progress of Oxygen Therapy in the Treatment of Chronic Heart Failure
DOI: 10.12677/ACM.2022.1281159, PDF,    科研立项经费支持
作者: 黄 洁：青海大学研究生院，青海 西宁；刘彦民*：青海省人民医院心血管内科，青海 西宁；刘楠楠：青海省心脑血管病专科医院心律失常二科，青海 西宁
关键词: 心力衰竭；氧疗；微压氧舱；Heart Failure； Oxygen Therapy； Micro-Pressure Oxygen Therapeutic Unit
摘要: 慢性心力衰竭是各种心脏疾病的终末阶段和主要的死亡原因，患病率及住院病死率随年龄增加显著上升。高压氧舱可以改善患者运动耐量，延缓心室重构，每次治疗时间仅1~2小时，明显提高了患者的依从性。微压氧舱有着和高压氧舱同样的疗效，但体积小、价格便宜、安全、易操作，可以居家使用，它通过微压、富氧、负离子等协同增效，提高人体细胞氧含量，使心肌缺氧迅速得到改善，改善血流动力学障碍。现就氧疗与心力衰竭关系研究进展进行综述，从微压氧舱治疗心衰方向为氧疗治疗心衰提供新思路。
Abstract: Chronic heart failure is the terminal stage and leading cause of death of various heart diseases, and the prevalence and hospital fatality rate increase significantly with age. The hyperbaric oxygen therapeutic unit can improve patients’ exercise tolerance and delay ventricular remodeling, and the duration of each treatment is only 1~2 hours, which significantly improves patient compliance. Micro pressure oxygen chamber has the same curative effect as high pressure oxygen chamber, but it is small, cheap, safe and easy to operate, and can be used at home. The micro pressure oxygen chamber increases the oxygen content of human cells through the synergistic effect of micro pressure, oxygen enrichment and negative ions, so that the myocardial hypoxia is rapidly improved and the hemodynamic disorder is improved. The research progress of the relationship between ox-ygen therapy and heart failure is reviewed, and a new idea is provided for the treatment of heart failure by oxygen therapy from the direction of micro-pressure oxygen chamber treatment of heart failure.
文章引用：黄洁, 刘彦民, 刘楠楠. 氧疗在慢性心力衰竭治疗中的研究进展[J]. 临床医学进展, 2022, 12(8): 8050-8056. https://doi.org/10.12677/ACM.2022.1281159

参考文献

[1] 胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220.
[2] Zhang, Y., Zhang, J., Butler, J., et al. (2017) Contemporary Epidemiology, Management, and Outcomes of Patients Hospitalized for Heart Failure in China: Results From the China Heart Failure (China-HF) Registry. Journal of Cardiac Failure, 23, 868-875. [Google Scholar] [CrossRef] [PubMed]
[3] 王宙, 周琳, 刘洋, 等. 慢性心力衰竭的流行病学研究现状及其防治研究进展[J]. 中国循证心血管医学杂志, 2019, 11(8): 1022-1024.
[4] 李智玲, 曹宏, 张锐. 心力衰竭药物治疗现状与进展[J]. 临床军医杂志, 2018, 46(10): 1212-1216.
[5] 李世军. 老年心力衰竭流行病学和病理生理学及预后的研究进展[J]. 中华老年心脑血管病杂志, 2021, 23(3): 318-320.
[6] Yamasaki, Y., Matsuura, K., Sasaki, D., et al. (2021) Assessment of Human Bioengineered Cardiac Tissue Function in Hypoxic and Re-Oxygenized Environments to Understand Functional Recovery in Heart Failure. Re-generative Therapy, 18, 66-75. [Google Scholar] [CrossRef] [PubMed]
[7] Morciano, G., Vitto, V., Bouhamida, E., et al. (2021) Mitochondrial Bioenergetics and Dynamism in the Failing Heart. Life (Basel), 11, 66-75. [Google Scholar] [CrossRef] [PubMed]
[8] Li, Y. and Liu, X. (2018) Novel Insights into the Role of Mitochondrial Fusion and Fission in Cardiomyocyte Apoptosis Induced by Ischemia/Reperfusion. Journal of Cellular Physiology, 233, 5589-5597. [Google Scholar] [CrossRef] [PubMed]
[9] 张鹏, 艾力曼•马合木提, 孙娟. 心肌能量代谢与慢性心力衰竭心室重构关系及心肌能量代谢药物应用的研究进展[J]. 中华实用诊断与治疗杂志, 2018, 32(1): 94-97.
[10] Cao, J.L., Adaniya, S.M., Cypress, M.W., et al. (2019) Role of Mitochondrial Ca(2+) Homeostasis in Cardiac Muscles. Archives of Biochemistry and Biophysics, 663, 276-287. [Google Scholar] [CrossRef] [PubMed]
[11] Reconditi, M., Care-mani, M., Pinzauti, F., et al. (2017) Myosin Filament Activation in the Heart Is Tuned to the Mechanical Task. Proceed-ings of the National Academy of Sciences of the United States of America, 114, 3240-3245. [Google Scholar] [CrossRef] [PubMed]
[12] Wenzl, F.A., Ambrosini, S., Mohammed, S.A., et al. (2021) In-flammation in Metabolic Cardiomyopathy. Frontiers in Cardiovascular Medicine, 8, Article ID: 742178. [Google Scholar] [CrossRef] [PubMed]
[13] 刘启方, 黄晶, 田龙海, 等. microRNA-25通过HMGB1途径降低缺氧/复氧H9C2心肌细胞纤维化[J]. 中国免疫学杂志, 2019, 35(12): 1416-1420.
[14] 陈纪烨, 马度芳, 王永成, 等. 免疫炎症反应在心力衰竭心肌纤维化中的研究进展[J]. 中国免疫学杂志, 2020, 36(20): 2534-2539.
[15] Lagan, J., Schelbert, E.B., Naish, J.H., et al. (2021) Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease with Heart Failure. JACC: Cardiovascular Imaging, 14, 1963-1973. [Google Scholar] [CrossRef] [PubMed]
[16] Canepa, M., Straburzynska-Migaj, E., Drozdz, J., et al. (2018) Characteristics, Treatments and 1-Year Prognosis of Hospitalized and Ambulatory Heart Failure Patients with Chronic Obstructive Pulmonary Disease in the European Society of Cardiology Heart Failure Long-Term Registry. European Journal of Heart Failure, 20, 100-110. [Google Scholar] [CrossRef] [PubMed]
[17] 王佳岳, 华毛, 刘汉芸. 内皮功能障碍在COPD中的研究进展[J]. 中华肺部疾病杂志(电子版), 2021, 14(5): 681-683.
[18] 栾英, 李敬蕊, 刘林林, 等. 基于miR-34a/Notch信号通路研究补肺益肾方对慢性阻塞性肺疾病大鼠模型免疫失衡和炎症反应的影响[J]. 中国免疫学杂志, 2022, 38(9): 1075-1081.
[19] Ciccarelli, M., Dawson, D., Falcao-Pires, I., et al. (2021) Reciprocal Organ Interactions during Heart Failure: A Position Paper from the ESC Working Group on Myocardial Function. Cardiovascular Research, 117, 2416-2433. [Google Scholar] [CrossRef] [PubMed]
[20] Tobin, M.J., Laghi, F. and Jubran, A. (2020) Why COVID-19 Silent Hypoxemia Is Baffling to Physicians. American Journal of Respiratory and Critical Care Medicine, 202, 356-360. [Google Scholar] [CrossRef] 
[21] Cannellotto, M., Duarte, M., Keller, G., et al. (2022) Hyper-baric Oxygen as an Adjuvant Treatment for Patients with COVID-19 Severe Hypoxaemia: A Randomised Controlled Trial. Emergency Medicine Journal, 39, 88-93. [Google Scholar] [CrossRef] [PubMed]
[22] 李苗, 王丽丽, 常冰梅. 血管内皮细胞功能损伤机制的研究进展[J]. 中国动脉硬化杂志, 2019, 27(8): 730-736.
[23] Pietschner, R., Kolwelter, J., Bosch, A., et al. (2021) Ef-fect of Empagliflozin on Ketone Bodies in Patients with Stable Chronic Heart Failure. Cardiovascular Diabetology, 20, Article No. 219. [Google Scholar] [CrossRef] [PubMed]
[24] Liang, S., Yu, H., Chen, X., et al. (2017) PDGF-BB/KLF4/VEGF Signaling Axis in Pulmonary Artery Endothelial Cell Angiogenesis. Cellular Physiology and Biochemistry, 41, 2333-2349. [Google Scholar] [CrossRef] [PubMed]
[25] 程忠, 毛哲哲, 胡彦峰, 等. 双水平无创正压通气对阻塞性睡眠呼吸暂停低通气综合征病人心脏节律及血管内皮功能的影响[J]. 中西医结合心脑血管病杂志, 2019, 17(10): 1549-1552.
[26] Shigetoshi, M., Hatanaka, K., Ogawa, A., et al. (2022) Oxygen Inhalation Can Selectively Dilate Pulmonary Arteries in Patients with Chronic Thromboembolic Pulmonary Hypertension before Balloon Angioplasty. Journal of Cardiology, 79, 265-269. [Google Scholar] [CrossRef] [PubMed]
[27] Rengasamy, S., Nassef, B., Bilotta, F., et al. (2021) Administration of Supplemental Oxygen. The New England Journal of Medicine, 385, e9. [Google Scholar] [CrossRef] 
[28] 曲川, 郭焱, 杨波. 急性冠脉综合征和心力衰竭中的合理氧疗[J]. 临床内科杂志, 2019, 36(1): 7-9.
[29] 肖立平, 邓俊国, 冯春晖, 等. 经鼻面罩持续气道内正压通气对阻塞性睡眠呼吸暂停低通气综合征伴心力衰竭患者心率变异性及心功能的影响研究[J]. 实用心脑肺血管病杂志, 2017, 25(1): 56-59.
[30] 张彬, 张恒. 射血分数保留的心力衰竭的治疗进展[J]. 岭南心血管病杂志, 2017, 23(4): 496-500.
[31] Kirby, J.P., Snyder, J., Schuerer, D., et al. (2019) Essentials of Hyperbaric Oxygen Therapy: 2019 Re-view. Missouri Medicine, 116, 176-179.
[32] Lalieu, R.C., Brouwer, R.J., Ubbink, D.T., et al. (2020) Hyperbaric Ox-ygen Therapy for Nonischemic Diabetic Ulcers: A Systematic Review. Wound Repair and Regeneration, 28, 266-275. [Google Scholar] [CrossRef] [PubMed]
[33] Leitman, M., Efrati, S., Fuchs, S., et al. (2020) The Effect of Hyperbaric Oxygenation Therapy on Myocardial Function. The International Journal of Cardiovascular Imaging, 36, 833-840. [Google Scholar] [CrossRef] [PubMed]
[34] 彭仲华. 高压氧治疗对无症状冠心病早期心功能减退者血流动力学的影响[J]. 特别健康, 2017(15): 59-60.
[35] Takemura, A. and Ishihara, A. (2017) Mild Hyperbaric Oxy-gen Inhibits Growth-Related Decrease in Muscle Oxidative Capacity of Rats with Metabolic Syndrome. Journal of Ath-erosclerosis and Thrombosis, 24, 26-38. [Google Scholar] [CrossRef] [PubMed]

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