阴道微生态与胎膜早破相关性研究进展

Research Progress on the Correlation between Vaginal Microecology and Premature Rupture of Membranes

摘要: 胎膜早破(Premature Rupture of Membrabes, PROM)，是妊娠晚期的一种常见并发症，其原因主要为生殖道的逆行性感染。多种微生物群落在女性阴道中栖居，而阴道菌群变化与胎膜早破息息相关。故通过评价孕产妇阴道微生态来了解其在胎膜早破发生和转归中所发挥的作用。目前第二代高通量测序技术已被该研究普遍应用，不但能获取阴道菌群的最宏观基因组信息，还可以有效弥补传统培养法所带来的认知缺陷。第二代高通量测序技术的应用可进一步分析阴道微生态动态变化与胎膜早破的相关性，为预防胎膜早破并做好临床预防工作提供理论基础。

Abstract: Premature rupture of membranes (PROM) is a common complication in the third trimester of pregnancy, which is mainly caused by retrograde infection of the reproductive tract. A variety of microbial communities inhabit the vagina of women, and the changes of vaginal flora are closely re-lated to premature rupture of membranes. Therefore, we can understand the role of vaginal micro-ecology in the occurrence and prognosis of premature rupture of membranes by evaluating the vaginal microecology of pregnant women. At present, the second-generation high-throughput se-quencing technology has been widely used in this research. It can not only obtain the most macro-scopic genomic information of vaginal flora, but also effectively compensate for the cognitive defects caused by traditional culture methods. The application of the second generation high- throughput sequencing technology can further analyze the correlation between the dynamic changes of vaginal micro ecology and premature rupture of membranes, and provide a theoretical basis for the pre-vention of premature rupture of membranes and clinical prevention.