维生素D缺乏与妊娠期疾病关系的研究进展
Research Progress on the Relationship between Vitamin D Deficiency and Gestational Diseases
DOI: 10.12677/ACM.2022.1291202, PDF,   
作者: 姚火娣, 刘东方*:重庆医科大学附属第二医院内分泌与代谢病科,重庆
关键词: 维生素D缺乏妊娠期疾病相关关系Vitamin D Deficiency Gestational Disease Correlation
摘要: 维生素D是人体必需的脂溶性维生素,它在调节钙、镁和磷的动态平衡及作为抗增殖和免疫调节介质方面发挥关键作用。近年来,随着我国生育政策的不断调整,人们生育需求的增加,妊娠期间维生素D缺乏的话题引起了广泛的关注,由于妊娠对维生素D的需求明显增加,维生素D缺乏与自然流产、妊娠期糖尿病、子痫前期、产后抑郁、早产等妊娠期疾病密切相关。本文旨在对维生素D缺乏与妊娠期疾病关系的研究进展进行综述,以期为孕妇维生素D缺乏的临床干预提供一定的依据。
Abstract: Vitamin D is an essential fat-soluble vitamin, which plays a key role in regulating the dynamic bal-ance of calcium, magnesium and phosphorus and as a medium of anti-proliferation and immuno-modulation. In recent years, with the continuous adjustment of China’s fertility policy, people’s fer-tility demand is increasing, and the topic of vitamin D deficiency during pregnancy has aroused widespread concern. Due to the increased demand for vitamin D in pregnancy, vitamin D deficiency is closely related to pregnancy diseases such as spontaneous abortion, gestational diabetes, preeclampsia, postpartum depression and preterm delivery. The purpose of this article is to review the research progress on the relationship between vitamin D deficiency and pregnancy diseases, in order to provide some basis for clinical intervention of vitamin D deficiency in pregnant women.
文章引用:姚火娣, 刘东方. 维生素D缺乏与妊娠期疾病关系的研究进展[J]. 临床医学进展, 2022, 12(9): 8342-8347. https://doi.org/10.12677/ACM.2022.1291202

参考文献

[1] Ramagopalan, S.V., Heger, A., Berlanga, A.J., et al. (2010) A ChIP-seq Defined Genome-Wide Map of Vitamin D Re-ceptor Binding: Associations with Disease and Evolution. Genome Research, 20, 1352-1360. [Google Scholar] [CrossRef] [PubMed]
[2] Holick, M.F. (2007) Vitamin D Deficiency. The New England Journal of Medicine, 357, 266-281. [Google Scholar] [CrossRef
[3] Muscogiuri, G., Altieri, B., Annweiler, C., et al. (2017) Vitamin D and Chronic Diseases: The Current State of the Art. Archives of Toxicology, 91, 97-107. [Google Scholar] [CrossRef] [PubMed]
[4] Lee, C.L., Ng, B.K., Wu, L.L., et al. (2017) Vitamin D Deficiency in Pregnancy at Term: Risk Factors and Pregnancy Outcomes. Hormone Molecular Biology and Clinical Investigation, 31. [Google Scholar] [CrossRef] [PubMed]
[5] Lin, S., Zhang, Y., Jiang, L., et al. (2022) Interactive Effects of Ma-ternal Vitamin D Status and Socio-Economic Status on the Risk of Spontaneous Abortion: Evidence from Henan Prov-ince, China. Nutrients, 14, Article No. 291. [Google Scholar] [CrossRef] [PubMed]
[6] Zhao, R., Zhou, L., Wang, S., et al. (2022) Association between Maternal Vitamin D Levels and Risk of Adverse Pregnancy Outcomes: A Systematic Review and Dose-Response Meta-Analysis. Food & Function, 13, 14-37. [Google Scholar] [CrossRef
[7] Robinson, M., Whitehouse, A.J., Newnham, J.P., et al. (2014) Low Maternal Serum Vitamin D during Pregnancy and the Risk for Postpartum Depression Symptoms. Archives of Women’s Mental Health, 17, 213-219. [Google Scholar] [CrossRef] [PubMed]
[8] Rai, R. and Regan, L. (2006) Recurrent Miscarriage. The Lancet, 368, 601-611. [Google Scholar] [CrossRef
[9] Mumford, S.L., Garbose, R.A., Kim, K., et al. (2018) Asso-ciation of Preconception Serum 25-Hydroxyvitamin D Concentrations with Livebirth and Pregnancy Loss: A Prospective Cohort Study. The Lancet Diabetes & Endocrinology, 6, 725-732. [Google Scholar] [CrossRef
[10] Tamblyn, J.A., Hewison, M., Wagner, C.L., et al. (2015) Immunological Role of Vitamin D at the Maternal-Fetal Interface. Journal of Endocrinology, 224, R107-R121. [Google Scholar] [CrossRef
[11] Chan, S.Y., Susarla, R., Canovas, D., et al. (2015) Vitamin D Promotes Human Extravillous Trophoblast Invasion in Vitro. Placenta, 36, 403-409. [Google Scholar] [CrossRef] [PubMed]
[12] Ciepiela, P., Dulęba, A.J., Kowaleczko, E., et al. (2018) Vita-min D as a Follicular Marker of Human Oocyte Quality and a Serum Marker of in Vitro Fertilization Outcome. Journal of Assisted Reproduction and Genetics, 35, 1265-1276. [Google Scholar] [CrossRef] [PubMed]
[13] Su, F.L., Lu, M.C., Yu, S.C., et al. (2021) Increasing Trend in the Prevalence of Gestational Diabetes Mellitus in Taiwan. Journal of Diabetes Investigation, 12, 2080-2088. [Google Scholar] [CrossRef] [PubMed]
[14] Yuan, X.S., Zhang, M., Wang, H.Y., et al. (2018) Increased Secreted Friz-zled-Related Protein 4 and Ficolin-3 Levels in Gestational Diabetes Mellitus Women. Endocrine Journal, 65, 499-508. [Google Scholar] [CrossRef
[15] Zhang, Y., Gong, Y., Xue, H., et al. (2018) Vitamin D and Gesta-tional Diabetes Mellitus: A Systematic Review Based on Data Free of Hawthorne Effect. BJOG, 125, 784-793. [Google Scholar] [CrossRef] [PubMed]
[16] Chen, C., Luo, Y., Su, Y., et al. (2019) The Vitamin D Receptor (VDR) Protects Pancreatic Beta Cells against Forkhead Box Class O1 (FOXO1)-Induced Mitochondrial Dysfunction and Cell Apoptosis. Biomedicine & Pharmacotherapy, 117, Article ID: 109170. [Google Scholar] [CrossRef] [PubMed]
[17] Yin, W.J., Tao, R.X., Hu, H.L., et al. (2020) The Association of Vitamin D Status and Supplementation during Pregnancy with Gestational Diabetes Mellitus: A Chinese Prospective Birth Cohort Study. The American Journal of Clinical Nutrition, 111, 122-130.
[18] Muyayalo, K.P., Huang, X.B., Qi-an, Z., et al. (2019) Low Circulating Levels of Vitamin D May Contribute to the Occurrence of Preeclampsia through Deregulation of Treg/Th17 Cell Ratio. American Journal of Reproductive Immunology, 82, e13168. [Google Scholar] [CrossRef] [PubMed]
[19] Hu, K.L., Zhang, C.X., Chen, P., et al. (2022) Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia, a Systematic Review and Meta-Analysis. Nutrients, 14, Article No. 999. [Google Scholar] [CrossRef] [PubMed]
[20] Magnus, M.C., Miliku, K., Bauer, A., et al. (2018) Vitamin D and Risk of Pregnancy Related Hypertensive Disorders: Mendelian Randomisation Study. BMJ, 361, k2167. [Google Scholar] [CrossRef] [PubMed]
[21] Phipps, E.A., Thadhani, R., Benzing, T., et al. (2019) Pre-Eclampsia: Pathogenesis, Novel Diagnostics and Therapies. Nature Reviews Nephrology, 15, 275-289. [Google Scholar] [CrossRef] [PubMed]
[22] Pollheimer, J., Vondra, S., Baltayeva, J., et al. (2018) Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment. Frontiers in Immunology, 9, Article No. 2597. [Google Scholar] [CrossRef] [PubMed]
[23] Pi, Y., Tian, X., Ma, J., et al. (2021) Vitamin D Alleviates Hypoxia/Reoxygenation-Induced Injury of Human Trophoblast HTR-8 Cells by Activating Autophagy. Placenta, 111, 10-18. [Google Scholar] [CrossRef] [PubMed]
[24] Pillai, R.R., Premkumar, N.R., Kattimani, S., et al. (2021) Reduced Maternal Serum Total, Free and Bioavailable Vitamin D Levels and Its Association with the Risk for Postpar-tum Depressive Symptoms. Archives of Medical Research, 52, 84-92. [Google Scholar] [CrossRef] [PubMed]
[25] Amini, S., Amani, R., Jafarirad, S., et al. (2022) The Effect of Vitamin D and Calcium Supplementation on Inflammatory Biomarkers, Estradiol Levels and Severity of Symptoms in Women with Postpartum Depression: A Randomized Double-Blind Clinical Trial. Nutritional Neuroscience, 25, 22-32. [Google Scholar] [CrossRef
[26] Nielsen, N.O., Strøm, M., Boyd, H.A., et al. (2013) Vita-min D Status during Pregnancy and the Risk of Subsequent Postpartum Depression: A Case-Control Study. PLOS ONE, 8, e80686. [Google Scholar] [CrossRef] [PubMed]
[27] WHO (1977) Recommended Definitions, Terminol-ogy and Format for Statistical Tables Related to the Perinatal Period and Use of a New Certificate for Cause of Perinatal Deaths. Modifications Recommended by FIGO as Amended October 14, 1976. Acta Obstetricia et Gynecologica Scan-dinavica, 56, 247-253.
[28] Fu, L., Chen, Y.H., Xu, S., et al. (2019) Oral Cholecalciferol Supplementation Alleviates Lipopolysaccharide-Induced Preterm Delivery Partially through Regulating Placental Steroid Hormones and Prostaglan-dins in Mice. International Immunopharmacology, 69, 235-244. [Google Scholar] [CrossRef] [PubMed]
[29] Abdelrahiem, S.K., Sharif, M.E., et al. (2022) Association be-tween Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case-Control Study. Nutrients, 14, Article No. 891. [Google Scholar] [CrossRef] [PubMed]
[30] Wang, S., Xin, X., Luo, W., et al. (2021) Association of Vitamin D and Gene Variants in the Vitamin D Metabolic Pathway with Preterm Birth. Nutrition, 89, Article ID: 111349. [Google Scholar] [CrossRef] [PubMed]
[31] Shao, B., Jiang, S., Muyiduli, X., et al. (2018) Vitamin D Pathway Gene Polymorphisms Influenced Vitamin D Level among Pregnant Women. Clinical Nutrition, 37, 2230-2237. [Google Scholar] [CrossRef] [PubMed]
[32] 王硕佳. 孕期维生素D及其代谢通路相关基因与早产的关联研究[D]: [博士学位论文]. 杭州: 浙江大学, 2020.
[33] Barchitta, M., Maugeri, A., La Rosa, M.C., et al. (2018) Sin-gle Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the “Mamma & Bambino” Cohort and a Meta-Analysis. Nutrients, 10, Article No. 1172. [Google Scholar] [CrossRef] [PubMed]
[34] Monier, I., Baptiste, A., Tsatsaris, V., et al. (2019) First Trimester Ma-ternal Vitamin D Status and Risks of Preterm Birth and Small-for-Gestational Age. Nutrients, 11, Article No. 3042. [Google Scholar] [CrossRef] [PubMed]
[35] Budhwar, S., Verma, P., Verma, R., et al. (2020) Altered Cord Serum 25-Hydroxyvitamin D Signaling and Placental Inflammation Is Associated with Pre-Term Birth. American Journal of Reproductive Immunology, 83, e13201. [Google Scholar] [CrossRef] [PubMed]