完全性葡萄胎1例诊疗体会并文献复习
A Case Report and Literature Review of the Diagnosis and the Treatment of Complete Hydatidiform Moles
DOI: 10.12677/ACM.2022.1291204, PDF,   
作者: 孙 琦：青岛大学医学院，山东 青岛；袁 芳*：青岛大学附属医院妇科，山东 青岛
关键词: 完全性葡萄胎；妊娠滋养细胞疾病；妊娠滋养细胞肿瘤；Complete Hydatidiform Mole； Gestational Trophoblastic Disease； Gestational Trophoblastic Neoplasm
摘要: 目的：报告1例完全性葡萄胎并结合文献讨论其诊断及治疗方法。方法：以病例报告的方式，结合国内外文献复习，综合分析完全性葡萄胎的诊断及治疗。结果：完全性葡萄胎的诊断主要以临床表现、血hcg水平及组织病理学为依据，以清宫术、化疗、手术为主要治疗方法。结论：完全性葡萄胎治疗以清宫术为主，根据是否存在恶变的高危因素选择是否进一步化疗等。
Abstract: Objective: To report a case of complete hydatidiform mole and discuss its diagnosis and treatment methods combined with the literature. Methods: The diagnosis and treatment of complete hydatid-iform mole were analyzed by means of case report and literature review. Results: The diagnosis of complete hydatidiform mole was mainly based on the clinical manifestations, blood hcg level and histopathology, and the treatments including uterine curettage, chemotherapy and surgery. Con-clusions: The main treatment to complete hydatidiform mole was uterine curettage and the chem-otherapy was selected according to the risk factors of malignant change.
文章引用：孙琦, 袁芳. 完全性葡萄胎1例诊疗体会并文献复习[J]. 临床医学进展, 2022, 12(9): 8355-8358. https://doi.org/10.12677/ACM.2022.1291204

参考文献

[1] Soper, J.T. (2021) Gestational Trophoblastic Disease: Current Evaluation and Management. Obstetrics and Gynecology, 137, 355-370. [Google Scholar] [CrossRef] 
[2] Sugrue, R., Foley, O., Elias, K.M., et al. (2021) Outcomes of Minimally Invasive versus Open Abdominal Hysterectomy in Patients with Gestational Tropho-blastic Disease. Gynecologic Oncology, 160, 445-449. [Google Scholar] [CrossRef] [PubMed]
[3] Lok, C., Frijstein, M. and van Trommel, N. (2021) Clinical Presentation and Diagnosis of Gestational Trophoblastic Disease. Best Practice & Research Clinical Obstetrics & Gy-naecology, 74, 42-52. [Google Scholar] [CrossRef] [PubMed]
[4] 计鸣良, 赵峻, 向阳. 葡萄胎诊治的研究进展[J]. 中国癌症防治杂志, 2020, 12(2): 126-130.
[5] 向阳. 妊娠滋养细胞疾病诊治中的问题与对策[J]. 中国实用妇科与产科杂志, 2011(9): 641-643.
[6] 刘俊玲. 预防性化疗对有恶变高危因素的葡萄胎患者疗效分析[J]. 北华大学学报(自然科学版), 2012, 13(5): 553-556.
[7] Kim, S.J., Na, Y.J., Jung, S.G., et al. (2007) Management of High-Risk Hydatidiform Mole and Persistent Gestational Trophoblastic Neoplasia: The Korean Experience. The Journal of Repro-ductive Medicine, 52, 819-830.
[8] Bolze, P.-A., Attia, J., Massardier, J., et al. (2015) Formalised Consensus of the European Organisation for Treatment of Trophoblastic Diseases on Management of Gestational Trophoblastic Diseases. European Journal of Cancer, 51, 1725-1731. [Google Scholar] [CrossRef] [PubMed]
[9] Zhao, P., Lu, Y., Huang, W., Tong, B. and Lu, W. (2019) Total Hysterectomy versus Uterine Evacuation for Preventing Post-Molar Ges-tational Trophoblastic Neoplasia in Patients Who Are at Least 40 Years Old: A Systematic Review and Meta-Analysis. BMC Cancer, 19, No. 13. [Google Scholar] [CrossRef] [PubMed]

为你推荐