肝移植器官保存液的临床研究进展
Progress in Clinical Research of Organ Preservation Fluid for Liver Transplantation
DOI: 10.12677/ACM.2022.1291214, PDF,   
作者: 王一翔, 王 蕾:青海大学研究生院,青海 西宁;吴世乐*, 朱文君:青海省人民医院普外科,青海 西宁
关键词: 器官保存液肝移植器官移植器官保存Organ Preservation Fluid Liver Transplantation Organ Transplantation Organ Preservation
摘要: 肝移植术是治疗终末期肝脏疾病的有效手段,而减少供体肝脏在运输过程中缺血状态下的损害是肝移植术后患者肝功能恢复的重要因素之一。随着肝移植手术技术的逐渐完善,供体肝脏的保存方式及保存液也逐步发展,但为了延长供肝保存的时间,降低缺氧、缺血造成的损伤,设计合理的器官保存液是当前临床工作中亟待解决的问题,因此本文将介绍器官保存液的临床研究进展,为以后肝脏器官保存液的研究提供参照。
Abstract: Liver transplantation is an effective treatment of end-stage liver disease, and reducing the damage of donor liver during transportation under ischemia is one of the important factors for the recovery of liver function after liver transplantation. Liver transplant technology is gradually perfect, the preservation of donor livers and preservation solution also gradually developed, but in order to ex-tend the liver to save time, reduce the damage of hypoxia and ischemia, designing a reasonable or-gan preservation solution is a problem to be solved in current clinical practice, so this article will introduce clinical research progress of organ preservation solution. It provides reference for the study of liver preservation fluid in the future.
文章引用:王一翔, 吴世乐, 朱文君, 王蕾. 肝移植器官保存液的临床研究进展[J]. 临床医学进展, 2022, 12(9): 8419-8426. https://doi.org/10.12677/ACM.2022.1291214

参考文献

[1] Ali, F., Dua, A. and Cronin, D.C. (2015) Changing Paradigms in Organ Preservation and Resuscitation. Current Opin-ion in Organ Transplantation, 20, 152-158. [Google Scholar] [CrossRef
[2] Ostróżka-Cieślik, A., Dolińska, B. and Ryszka, F. (2018) Tips for Optimizing Organ Preservation Solutions. Acta Biochimica Polonica, 65, 9-15. [Google Scholar] [CrossRef] [PubMed]
[3] Reynolds, A.C., Asopa, S., Modi, A. and King, N. (2021) HTK ver-sus Multidosecardioplegias for Myocardial Protection in Adult Cardiac Surgery: A Meta-Analysis. Journal of Cardiac Surgery, 36, 1334-1343. [Google Scholar] [CrossRef] [PubMed]
[4] Mohr, A., Brockmann, J.G. and Becker, F. (2020) HTK-N: Modified His-tidine-Tryptophan-Ketoglutarate Solution-A Promising New Tool in Solid Organ Preservation. International Journal of Molecular Sciences, 21, Article No. 6468. [Google Scholar] [CrossRef] [PubMed]
[5] Van Den Eynde, J., Achtergaele, J., Fieuws, S., Jochmans, I., Sainz-Barriga, M., Monbaliu, D., Pirenne, J. and Gilbo, N. (2021) The Effect of Organ Preservation Solutions on Short-Term Outcomes after Liver Transplantation: A Single-Center Retrospective Study. Transplant International, 34, 327-338. [Google Scholar] [CrossRef] [PubMed]
[6] Meine, M.H., Leipnitz, I., Zanotelli, M.L., Schlindwein, E.S., Kiss, G., Martini, J., De Medeiros Fleck AJr, Mucenic, M., De Mello Brandão, A., Marroni, C.A. and CracoCantisani, G.P. (2015) Comparison between IGL-1 and HTK Preservation Solutions in Deceased Donor Liver Transplantation. Trans-plantation Proceedings, 47, 888-893. [Google Scholar] [CrossRef] [PubMed]
[7] Xu, X., Zhu, Y.F., Lv, T., Zheng, J.L., Li, Y.K., Zhang, B.H., Jiang, L. and Yang, J.Y. (2020) Histidine-Tryptophan- Ketoglutarate Solution versus University of Wisconsin So-lution in Adult-to-Adult Living Donor Liver Transplantation: A Propensity Score Matching Analysis from Mainland China. Medicine, 99, e23584. [Google Scholar] [CrossRef
[8] Liu, Q., Bruns, H., Schultze, D., Xue, Y., Zorn, M., Flechtenmacher, C., Straub, B.K., Rauen, U. and Schemmer, P. (2012) HTK-N, a Modified HTK Solution, Decreases Preservation Injury in a Model of Microsteatotic Rat Liver Transplantation. Langenbeck’s Archives of Surgery, 397, 1323-1331. [Google Scholar] [CrossRef] [PubMed]
[9] Lautenschläger, I., Pless-Petig, G., Middel, P., De Groot, H., Rauen, U. and Stojanovic, T. (2018) Cold Storage Injury to Rat Small-Bowel Transplants—Beneficial Effect of a Modified HTK Solution. Transplantation, 102, 1666-1673. [Google Scholar] [CrossRef
[10] Nishime, K., Miyagi-Shiohira, C., Kuwae, K., Tamaki, Y., Yonaha, T., Sakai-Yonaha, M., Saitoh, I., Watanabe, M. and Noguchi, H. (2021) Preservation of Pancreas in the Univer-sity of Wisconsin Solution Supplemented with AP39 Reduces Reactive Oxygen Species Production and Improves Islet Graft Function. American Journal of Transplantation, 21, 2698-2708. [Google Scholar] [CrossRef] [PubMed]
[11] Stewart, Z.A. (2015) UW Solution: Still the “Gold Standard” for Liver Transplantation. American Journal of Transplantation, 15, 295-296. [Google Scholar] [CrossRef] [PubMed]
[12] Verhoven, B.M., Karim, A.S., Bath, N.M., SarabiaFahl, C.J., Wilson, N.A., Redfield 3rd, R.R. and Fahl, W.E. (2020) Significant Improvement in Rat Kidney Cold Storage Using UW Organ Preservation Solution Supplemented with the Immediate-Acting PrC-210 Free Radical Scavenger. Transplantation Direct, 6, e578. [Google Scholar] [CrossRef
[13] Gochi, M., Kato, F., Toriumi, A., Kawagoe, T., Yotsuya, S., Ishii, D., Otani, M., Nishikawa, Y., Furukawa, H. and Matsuno, N. (2020) A Novel Preservation Solution Containing Quercetin and Sucrose for Porcine Kidney Transplantation. Transplant Direct, 6, e624. [Google Scholar] [CrossRef
[14] Petrowsky, H. and Clavien, P.A. (2015) Chapter 44 - Prin-ciples of Liver Preservation. In: Saunders, W.B., Ed., Transplantation of the Liver, 3rd Edition, Elsevier Inc., Amsterdam, 582-599. [Google Scholar] [CrossRef
[15] Sutherasan, M., Uthaithammarat, T., Taesombat, W., Nonthasoot, B., Nivatvong, S., Worasitha, A., Wongisaret, K., Kanthawong, W. and Sirichindakul, B. (2020) Combina-tion of Euro-Collins and University of Wisconsin Solution: An Effective and Economic Substitute for Organ Procure-ment. Transplantation Proceedings, 52, 50-53. [Google Scholar] [CrossRef] [PubMed]
[16] Rao, F., Yang, J., Gong, C., Huang, R., Wang, Q. and Shen, J. (2018) Systematic Review of Preservation Solutions for Allografts for Liver Transplantation Based on a Net-work Meta-Analysis. International Journal of Surgery, 54, 1-6. [Google Scholar] [CrossRef] [PubMed]
[17] Savier, E., Brustia, R., Golmard, J.L. and Scatton, O. (2020) Col-laborators. Influence of 4 Preservation Solutions on ICU Stay, Graft and Patient Survival Following Liver Transplanta-tion. Journal of Visceral Surgery, 157, 87-97. [Google Scholar] [CrossRef] [PubMed]
[18] Pueyo-Périz, E.M., Cepeda, C., Sánchez, B., Villegas, T., Briceño, J., Álamo, J.M., Artacho, G.S., Marín, L.M., Bernal, C. and Bravo, M.Á.G. (2022) Liver Transplantation: Analysis of Preservation Solutions in the Andalusian Registry. Transplantation Proceedings, 54, 15-17. [Google Scholar] [CrossRef] [PubMed]
[19] Yoshida, T., Alam, M.E., Hanafusa, K., Tsujimoto, Y., Tsukamoto, M., Kanegi, R., Inaba, T., Sugiura, K. and Hatoya, S. (2022) Effects of the Preservation Medium and Storage Duration of Domestic Cat Ovaries on the Maturational and Developmental Competence of Oocytes in Vitro. Journal of Reproduction and Development, 68, 160-164. [Google Scholar] [CrossRef] [PubMed]
[20] Zhao, X., Koshiba, T., Nakamura, T., Tsuruyama, T., Li, Y., Bando, T., Wada, H. and Tanaka, K. (2008) ET-Kyoto Solution Plus Dibutyryl Cyclic Adenosine Monophosphate Is Superior to University of Wisconsin Solution in Rat Liver Preservation. Cell Transplantation, 17, 99-109. [Google Scholar] [CrossRef] [PubMed]
[21] Panisello-Roselló, A., Verde, E., Lopez, A., Flores, M., Folch-Puy, E., Rolo, A., Palmeira, C., Hotter, G., Carbonell, T., Adam, R. and Roselló-Catafau, J. (2018) Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK. Interna-tional Journal of Molecular Sciences, 19, Article No. 348. [Google Scholar] [CrossRef] [PubMed]
[22] Habran, M., De Beule, J. and Jochmans, I. (2020) IGL-1 Preservation Solution in Kidney and Pancreas Transplantation: A Systematic Review. PLOS ONE, 15, e0231019. [Google Scholar] [CrossRef] [PubMed]
[23] Zaouali, M.A., Ben Abdennebi, H., Padrissa-Altés, S., Alfany-Fernandez, I., Rimola, A. and Roselló-Catafau, J. (2011) How Institut Georges Lopez Preservation Solution Pro-tects Nonsteatotic and Steatotic Livers against Ischemia- Reperfusion Injury. Transplantation Proceedings, 43, 77-79. [Google Scholar] [CrossRef] [PubMed]
[24] Bardallo, R.G., Company-Marin, I., Folch-Puy, E., Rosel-ló-Catafau, J., Panisello-Rosello, A. and Carbonell, T. (2022) PEG35 and Glutathione Improve Mitochondrial Function and Reduce Oxidative Stress in Cold Fatty Liver Graft Preservation. Antioxidants, 11, Article No. 158. [Google Scholar] [CrossRef] [PubMed]
[25] Bardallo, R.G., Da Silva, R.T., Carbonell, T., Palmeira, C., Folch-Puy, E., Roselló-Catafau, J., Adam, R. and Panisello-Rosello, A. (2022) Liver Graft Hypothermic Static and Oxygenated Per-fusion (HOPE) Strategies: A Mitochondrial Crossroads. International Journal of Molecular Sciences, 23, Article No. 5742. [Google Scholar] [CrossRef] [PubMed]
[26] Kayawake, H., Chen-Yoshikawa, T.F., Saito, M., Yamagishi, H., Yoshizawa, A., Hirano, S.I., Kurokawa, R., Date, H. (2021) Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model. The Annals of Thoracic Surgery, 111, 246-252. [Google Scholar] [CrossRef] [PubMed]
[27] Uto, K., Sakamoto, S., Que, W., Shimata, K., Hashimoto, S., Sakisaka, M., Narita, Y., Yoshii, D., Zhong, L., Komohara, Y., Li, X.K., Inomata, Y. and Hibi, T. (2019) Hydro-gen-Rich Solution Attenuates Cold Ischemia-Reperfusion Injury in Rat Liver Transplantation. BMC Gastroenterology, 19, Article No. 25. [Google Scholar] [CrossRef] [PubMed]
[28] Martins, P.N., Berendsen, T.A., Yeh, H., Bruinsma, B.G., Izamis, M.L., Op Den Dries, S., Gillooly, A.R., Porte, R., Yarmush, M.L., Uygun, K. and Markmann, J.F. (2019) Oxygenated UW Solution Decreases ATP Decay and Improves Survival after Transplantation of DCD Liver Grafts. Transplantation, 103, 363-370. [Google Scholar] [CrossRef
[29] Kumarasinghe, G., Gao, L., Hicks, M., Villanueva, J., Doyle, A., Rao, P., RuQiu, M., Jabbour, A., Iyer, A., Chew, H.C., Hayward, C.S., Macdonald, P. (2016) Improved Heart Function from Older Donors Using Pharmacologic Conditioning Strategies. The Journal of Heart and Lung Transplan-tation, 35, 636-646. [Google Scholar] [CrossRef] [PubMed]
[30] Ostróżka-Cieślik, A. and Dolińska, B. (2019) Pharmacological Benefits and Risk of Using Hormones in Organ Perfusion and Preservation Solutions in the Aspect of Minimizing He-patic Ischemia-Reperfusion Injury During Storage. BioMed Research International, 2019, Article ID: 6467134. [Google Scholar] [CrossRef] [PubMed]
[31] Saruç, M., Karaarslan, M., Rasa, K., Saygili, O., Ince, U., Baysal, C., Pour, P.M., Cakmakçi, M. and Tözün, N. (2009) Pancreatic Cancer and Glucose Metabolism. Turkish Journal of Gas-troenterology, 20, 257-260. [Google Scholar] [CrossRef] [PubMed]
[32] Stern, S., Bezinover, D., Rath, P.M., Paul, A. and Saner, F.H. (2022) Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter? Journal of Clinical Medicine, 10, Article No. 2022. [Google Scholar] [CrossRef] [PubMed]
[33] Meier, R.P.H., Andrey, D.O., Sun, P., Niclauss, N., Bédat, B., De-muylder-Mischler, S., Borot, S., Benhamou, P.Y., Wojtusciszyn, A., Buron, F., Pernin, N., Muller, Y.D., Bosco, D., Van Delden, C. and Berney, T. (2018) Pancreas Preservation Fluid Microbial Contamination Is Associated with Poor Is-let Isolation Outcomes—A Multi-Centre Cohort Study. Transplant International, 31, 917-929. [Google Scholar] [CrossRef] [PubMed]