基于网络药理学探讨乌灵菌粉抗阿尔兹海默症的作用机制

Study on the Mechanism of Action of Wuling against Alzheimer’s Disease Based on Network Pharmacology

摘要: 阿尔兹海默症对患者的正常生活及家庭造成严重影响，已经成为神经医学亟需解决的难题。本文运用网络药理学探究乌灵菌粉抗阿尔兹海默症的作用机制。数据库筛选阿尔茨海默症相关治疗靶点及乌灵菌粉关键活性成分，获取交集靶点，软件构建交集靶点蛋白相互作用网络，挖掘互作网络中的核心靶点，最终获得乌灵菌粉抗阿尔兹海默症的潜在信号通路。网络药理学结果表明，乌灵菌粉可能作用于ACE、HSD17B1、NOS2和BACE1靶点调控甾类激素生物合成信号通路，发挥抗阿尔兹海默症作用。 Alzheimer’s disease has a serious impact on the normal life of patients and their families, which has become an urgent problem to be solved in neuromedicine. In this paper, network pharmacology was used to explore the action mechanism of Wuling against Alzheimer’s disease. The database was used to screen the Alzheimer’s disease-related therapeutic targets and the key active ingredients of Wuling, and the intersection targets were obtained. Then, the protein interaction network of intersection targets was constructed, and the core targets in the interaction network were excavated, and the potential signaling pathway of Wuling powder against Alzheimer’s disease was finally obtained. The results of network pharmacology showed that Wuling may act on ACE, HSD17B1, NOS2 and BACE1 targets to regulate steroid hormone biosynthesis signaling pathway and play an anti-Alzheimer’s effect.