IgG4相关性肺病
IgG4-Related Lung Disease
DOI: 10.12677/ACM.2022.1291217, PDF,   
作者: 梁 楠, 戚 萌, 李钰婵:西安医学院,陕西 西安;兀 威:西安医学院第二附属医院呼吸内科,陕西 西安;杨淑梅*:陕西省人民医院呼吸与危重症一科,陕西 西安
关键词: IgG4相关性疾病IgG4相关性肺病临床表现病理影像学诊断治疗IgG4-RD IgG4-RLD Clinical Manifestations Pathology Imaging Diagnosis Treatment
摘要: IgG4相关性疾病(IgG4-related disease, IgG4-RD)是一种原因不明的多系统累及的慢性纤维炎症性疾病。IgG4相关性肺病(IgG4-related lung disease, IgG4-RLD)是IgG4-RD累及肺部,具有一系列的临床特点、组织病理学、血清学、影像学特征。在临床工作中,由于IgG4-RLD的临床表现及诊断缺乏特异性,影像学不典型,人们对该疾病的认识不足,存在误诊、漏诊等现象。为进一步提高IgG4-RLD的诊断水平,本文将对IgG4-RLD的临床研究进展加以综述。
Abstract: IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory disease with multiple system in-volvement of unknown cause. IgG4-related lung disease (IgG4-RLD) is a pulmonary disease involv-ing IgG4-RD and has a series of clinical, histopathological, serological and radiological features. In clinical work, due to the lack of specificity of clinical manifestations, diagnosis and atypical imaging of IgG4-RLD, people have insufficient understanding of this disease, and misdiagnosis, missed diag-nosis and delayed diagnosis exist. In order to further improve the diagnostic level of IgG4-RLD, this review will review the clinical research progress of IgG4-RLD.
文章引用:梁楠, 戚萌, 李钰婵, 兀威, 杨淑梅. IgG4相关性肺病[J]. 临床医学进展, 2022, 12(9): 8438-8444. https://doi.org/10.12677/ACM.2022.1291217

参考文献

[1] Aithal, G.P., Breslin, N.P. and Gumustop, B. (2001) High Serum IgG4 Concentrations in Patients with Sclerosing Pan-creatitis. New England Journal of Medicine, 345, 147-148. [Google Scholar] [CrossRef
[2] Adam, Z., Adamova, Z., Rehak, Z., et al. (2021) IgG4-Releated Disease. Klinicka Onkologie, 34, 92-102. [Google Scholar] [CrossRef] [PubMed]
[3] Okubo, T., Nakashima, N., Tokunaga, Y., et al. (2022) IgG4-Related Lung Disease with Recurrent Pulmonary Lesions during Steroid Therapy and Difficulty in Differentiating from Malig-nancy: A Case Report. Journal of Cardiothoracic Surgery, 17, Article No. 62. [Google Scholar] [CrossRef] [PubMed]
[4] Carballo, I., Gonzalez-Quintela, A., Sopena, B., et al. (2021) Immunoglobulin G4-Related Disease: What an Allergist Should Know. Journal of Investigational Allergology and Clin-ical Immunology, 31, 212-227. [Google Scholar] [CrossRef] [PubMed]
[5] Taniguchi, T., Ko, M., Seko, S., et al. (2004) Interstitial Pneumonia Asso-ciated with Autoimmune Pancreatitis. Gut, 53, 770-771.
[6] Dong, L.L., Sheikh, I.S., Huang, A.H., et al. (2021) Im-munoglobulin G4-Related Disease: Case Report and Literature Review. Immunologic Research, 69, 415-421. [Google Scholar] [CrossRef] [PubMed]
[7] Liu, J., Liu, Y., Shen, X., et al. (2021) Clinicopathological Characteristics of IgG4-Related Lung Disease. BMC Pulmonary Medicine, 21, Article No. 413. [Google Scholar] [CrossRef] [PubMed]
[8] Xiao, J., Hu, B., Cheng, D., et al. (2020) Features of IgG4-Related Lung Disease on 18F-FDG PET/Computed Tomography Imaging. Nuclear Medicine Communications, 41, 933-941. [Google Scholar] [CrossRef
[9] Matsui, S., Taki, H., Shinoda, K., et al. (2012) Respiratory Involvement in IgG4-Related Mikulicz’s Disease. Modern Rheumatology, 22, 31-39. [Google Scholar] [CrossRef] [PubMed]
[10] Sekiguchi, H., Horie, R., Aksamit, T.R., et al. (2013) Immuno-globulin G4-Related Disease Mimicking Asthma. Canadian Respiratory Journal, 20, 87-89. [Google Scholar] [CrossRef] [PubMed]
[11] Choi, J.H., Sim, J.K., Oh, J.Y., et al. (2014) A Case of IgG4-Related Disease Presenting as Massive Pleural Effusion and Thrombophlebitis. Tuberculosis and Respiratory Diseases (Seoul), 76, 179-183. [Google Scholar] [CrossRef] [PubMed]
[12] Zhou, Y., Shao, L., Ruan, W., et al. (2019) Pulmonary Vascular Involvement of IgG4-Related Disease: Case Series with a PRISMA-Compliant Systemic Review. Medicine (Baltimore), 98, e14437. [Google Scholar] [CrossRef
[13] Umehara, H., Okazaki, K., Nakamura, T., et al. (2017) Cur-rent Approach to the Diagnosis of IgG4-Related Disease—Combination of Comprehensive Diagnostic and Or-gan-Specific Criteria. Modern Rheumatology, 27, 381-391. [Google Scholar] [CrossRef] [PubMed]
[14] Matsui, S., Hebisawa, A., Sakai, F., et al. (2013) Immuno-globulin G4-Related Lung Disease: Clinicoradiological and Pathological Features. Respirology, 18, 480-487. [Google Scholar] [CrossRef] [PubMed]
[15] 韩国敬, 胡红, 毛丹, 等. IgG4相关性肺疾病八例临床特征分析[J]. 中华结核和呼吸杂志, 2017, 40(3): 193-198.
[16] Wang, A., Fan, J., Chen, X., et al. (2018) An Initial Exploration for Comprehensive Assessment of IgG4-Related Lung Disease: Analyses on the Cases Enrolled from a Systematic Review. Journal of Thoracic Disease, 10, 1825-1841. [Google Scholar] [CrossRef] [PubMed]
[17] Masaki, Y., Kurose, N., Yamamoto, M., et al. (2012) Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. Interna-tional Journal of Rheumatology, 2012, Article ID: 580814. [Google Scholar] [CrossRef] [PubMed]
[18] Culver, E.L., Sadler, R., Simpson, D., et al. (2016) Elevated Serum IgG4 Levels in Diagnosis, Treatment Response, Organ Involve-ment, and Relapse in a Prospective IgG4-Related Disease UK Cohort. The American Journal of Gastroenterology, 111, 733-743. [Google Scholar] [CrossRef] [PubMed]
[19] Idoyaga, P., Fielli, M., Gonzalez, A., et al. (2018) IgG4-Related Interstitial Lung Disease. Medicina (B Aires), 78, 449-452.
[20] Zhang, P.P., Zhao, J.Z., Wang, M., et al. (2017) The Clinical Characteristics of 346 Patients with IgG4-Related Disease. Chinese Journal of Internal Medicine, 56, 644-649.
[21] Lv, X., Gao, F., Liu, Q., et al. (2018) Clinical and Pathological Characteristics of IgG4-Related Interstitial Lung Disease. Experimental and Therapeutic Medicine, 15, 1465-1473. [Google Scholar] [CrossRef] [PubMed]
[22] Umehara, H., Okazaki, K., Masaki, Y., et al. (2012) Comprehensive Diagnostic Criteria for IgG4-Related Disease (IgG4-RD), 2011. Modern Rheumatology, 22, 21-30. [Google Scholar] [CrossRef] [PubMed]
[23] Cheuk, W. and Chan, J.K. (2012) Lymphadenopathy of IgG4-Related Disease: An Underdiagnosed and Overdiagnosed Entity. Seminars in Diagnostic Pathology, 29, 226-234. [Google Scholar] [CrossRef] [PubMed]
[24] Matsui, S. (2019) IgG4-Related Respiratory Disease. Modern Rheumatology, 29, 251-256. [Google Scholar] [CrossRef] [PubMed]
[25] Khosroshahi, A., Wallace, Z.S., Crowe, J.L., et al. (2015) International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease. Arthritis & Rheumatology, 67, 1688-1699. [Google Scholar] [CrossRef] [PubMed]
[26] Maritati, F., Peyronel, F. and Vaglio, A. (2020) IgG4-Related Disease: A Clinical Perspective. Rheumatology (Oxford), 59, i123-i131. [Google Scholar] [CrossRef] [PubMed]
[27] 王伟兰, 郭代红, 刘思源, 等. 264例利妥昔单抗超适应症用药的综合评价研究[J]. 中国药物应用与监测, 2020, 17(6): 381-386.
[28] Campochiaro, C., Della-Torre, E., Lanzillotta, M., et al. (2020) Long-Term Efficacy of Mainte-nance Therapy with Rituximab for IgG4-Related Disease. European Journal of Internal Medicine, 74, 92-98. [Google Scholar] [CrossRef] [PubMed]