平均血小板体积与精索静脉曲张炎症病理相关性的研究进展

Research Progress on the Relationship between Mean Platelet Volume and Inflammatory Pathology of Varicocele

摘要: 精索静脉曲张是男性常见疾病之一，严重影响着患者的生育功能。目前，其病理生理机制尚不完全明确。近年来，平均血小板体积在精索静脉曲张炎症病理过程中的变化引起了诸多关注。平均血小板体积近年来被广泛视为血小板功能及活化程度的指标，而血小板与炎症存在复杂的双向关系，血小板可诱导并维持炎症反应，炎症反应亦可调节血小板的活化及数量变化。炎症作为精索静脉曲张重要的病理生理机制之一，对平均血小板体积会产生巨大影响。深入了解平均血小板体积与精索静脉曲张的相关性及其内在作用原理，对研究精索静脉曲张病理生理机制以及潜在治疗靶点等具有积极意义。本文就平均血小板体积与精索静脉曲张炎症病理相关性的最新研究进展进行综述。

Abstract: Varicocele is one of the most common diseases in men, which severely affects the reproductive func-tion of its patients. Its pathophysiological mechanism remains s mystery at present. In recent years, much attention has been paid to the changes of mean platelet volume in the pathological process of varicocele inflammation. Mean platelet volume has been widely regarded as an indicator of platelet function and activation. There is a complex two-way relationship between platelets and inflamma-tion. Platelets can induce and maintain inflammation, and inflammation can also regulate platelet activation and quantitative changes. As one of the important pathophysiological mechanisms of varicocele, inflammation has a great impact on the mean platelet volume. An in-depth understand-ing of the correlation and internal mechanism between mean platelet volume and varicocele is of positive significance to the study of pathophysiological mechanism and potential therapeutic tar-gets of varicocele. This article reviews the latest research progress on the relationship between mean platelet volume and inflammatory pathology of varicocele.