可降解稀土镁合金在骨科中的研究进展
Research Progress of Degradable Rare Earth Magnesium Alloys in Orthopedics
DOI: 10.12677/ACM.2022.1291234, PDF,   
作者: 吕 萌:西安医学院,陕西 西安;刘时璋*:陕西省人民医院,陕西 西安
关键词: 可生物降解金属稀土镁合金骨科Biodegradable Metals Rare Earth Magnesium Alloy Orthopedics
摘要: 在骨科中,与不可降解金属相比,镁合金作为可生物降解金属,可以在体内降解,达到在无需手术干预的情况下完全移除植入物,这减轻了患者的痛苦和经济负担。然而目前其腐蚀速率和机械性能方面存在缺陷,这可以通过合金化途径来得以改善。稀土元素作为合金化元素之一,由于其独特的化学和物理性质受到了越来越多的关注。因此,本文将以可降解稀土镁合金在骨科中的研究进展进行论述。
Abstract: Compared with non-degradable metals, magnesium alloys, as biodegradable metals, can be de-graded in vivo to achieve complete removal of implants without surgical intervention in orthopedics, which reduces the pain and financial burden of patients. However, there are defects in corrosion rate and mechanical properties, which can be improved by alloying. As one of alloying elements, rare earth elements have attracted more and more attention due to their unique chemical and physical properties. Therefore, this paper will discuss the research progress of degradable rare earth magnesium alloy in orthopedics.
文章引用:吕萌, 刘时璋. 可降解稀土镁合金在骨科中的研究进展[J]. 临床医学进展, 2022, 12(9): 8547-8552. https://doi.org/10.12677/ACM.2022.1291234

参考文献

[1] Chen, B., Liang, Y., Bai, L., et al. (2020) Sustained Release of Magnesium Ions Mediated by Injectable Self-Healing Adhesive Hydrogel Promotes Fibrocartilaginous Interface Regeneration in the Rabbit Rotator Cuff Tear Model. Chemical Engineering Journal, 396, Article ID: 125335. [Google Scholar] [CrossRef
[2] Mehrjou, B., Dehghan-Baniani, D., Shi, M., et al. (2020) Nanopatterned Silk-Coated AZ31 Magnesium Alloy with Enhanced Anti-bacterial and Corrosion Properties. Materials Science and Engineering: C, 116, Article ID: 111173. [Google Scholar] [CrossRef] [PubMed]
[3] 周盟, 黄艺聪, 康斌. 骨科可降解镁合金生物材料的研究进展[J]. 中华骨与关节外科杂志, 2020, 13(5): 433-440.
[4] Bian, D., Deng, J., Li, N., et al. (2018) In Vitro and in Vivo Studies on Biomedical Magnesium Low-Alloying with Elements Gadolinium and Zinc for Orthopedic Implant Applica-tions. ACS Applied Materials & Interfaces, 10, 4394-4408. [Google Scholar] [CrossRef] [PubMed]
[5] Wu, D.T., Munguia-Lopez, J.G., Cho, Y.W., et al. (2021) Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine. Molecules, 26, Article No. 7043. [Google Scholar] [CrossRef] [PubMed]
[6] Wu, X., Wang, Z., Li, H., et al. (2019) Biomechanical Evaluation of Osteoporotic Fracture: Metal Fixation versus Absorbable Fixation in Saw-bones Models. Injury, 50, 1272-1276. [Google Scholar] [CrossRef] [PubMed]
[7] Amini, A.R., Wallace, J.S. and Nukavarapu, S.P. (2011) Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants. Journal of Long-Term Effects of Medical Implants, 21, 93-122. [Google Scholar] [CrossRef
[8] Vormann, J. (2003) Magnesium: Nutrition and Metabolism. Molecular Aspects of Medicine, 24, 27-37. [Google Scholar] [CrossRef
[9] Musso, C.G. (2009) Magnesium Metabolism in Health and Disease. International Urology and Nephrology, 41, 357-362. [Google Scholar] [CrossRef] [PubMed]
[10] 姜可新, 李江. 可降解生物医用镁基材料在骨植入方面的研究进展[J]. 国际老年医学杂志, 2022, 43(2): 241-244.
[11] Li, Y., Liu, L., Wan, P., et al. (2016) Biodegradable Mg-Cu Alloy Implants with Antibacterial Activity for the Treatment of Osteomyelitis: In Vitro and in Vivo Evaluations. Biomaterials, 106, 250-263. [Google Scholar] [CrossRef] [PubMed]
[12] Luo, Y., Zhang, C., Wang, J., et al. (2021) Clinical Transla-tion and Challenges of Biodegradable Magnesium-Based Interference Screws in ACL Reconstruction. Bioactive Materi-als, 6, 3231-3243. [Google Scholar] [CrossRef] [PubMed]
[13] Li, X., Liu, X., Wu, S., et al. (2016) Design of Magnesium Alloys with Controllable Degradation for Biomedical Implants: From Bulk to Surface. Acta Biomaterialia, 45, 2-30. [Google Scholar] [CrossRef] [PubMed]
[14] Ji, X.J., Gao, L., Liu, J.C., et al. (2019) Corrosion Resistance and Antibacterial Properties of Hydroxyapatite Coating Induced by Gentamicin-Loaded Polymeric Multilayers on Magnesium Alloys. Colloids and Surfaces B: Biointerfaces, 179, 429-436. [Google Scholar] [CrossRef] [PubMed]
[15] Ding, Y., Wen, C., Hodgson, P., et al. (2014) Effects of Al-loying Elements on the Corrosion Behavior and Biocompatibility of Biodegradable Magnesium Alloys: A Review. Jour-nal of Materials Chemistry B, 2, 1912-1933. [Google Scholar] [CrossRef
[16] 张雁儒, 杨越, 徐景超, 李昊, 李洁洁, 余进伟. 新型稀土镁合金螺钉体内促骨修复及体外生物相容性研究[J]. 宁波大学学报(理工版). 2022, 35(1): 11-17.
[17] Liu, J., Bian, D., Zheng, Y., et al. (2020) Comparative in Vitro Study on Binary Mg-RE (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) Alloy Systems. Acta Biomaterialia, 102, 508-528. [Google Scholar] [CrossRef] [PubMed]
[18] Zhao, X., Shi, L.L. and Xu, J. (2013) Biodegradable Mg-Zn-Y Alloys with Long-Period Stacking Ordered Structure: Optimization for Mechanical Properties. Journal of the Mechanical Behavior of Biomedical Materials, 18, 181-190. [Google Scholar] [CrossRef] [PubMed]
[19] Liu, L., Yuan, F., Zhao, M., et al. (2017) Rare Earth Element Yttrium Modified Mg-Al-Zn Alloy: Microstructure, Degradation Properties and Hardness. Materials, 10, Article No. 477. [Google Scholar] [CrossRef] [PubMed]
[20] Chen, J., Tan, L., Etim, I.P., et al. (2018) Comparative Study of the Effect of Nd and Y Content on the Mechanical and Biodegradable Properties of Mg-Zn-Zr-xNd/Y (x=0.5, 1, 2) Alloys. Materials Technology, 33, 659-671. [Google Scholar] [CrossRef
[21] Kania, A., Nowosielski, R., Gawlas-Mucha, A., et al. (2019) Mechanical and Corrosion Properties of Mg-Based Alloys with Gd Addition. Materials, 12, Article No. 1775. [Google Scholar] [CrossRef] [PubMed]
[22] Ding, Y., Lin, J., Wen, C., et al. (2016) Mechanical Properties, in Vitro Corrosion and Biocompatibility of Newly Developed Biodegradable Mg-Zr-Sr-Ho Alloys for Biomedical Applications. Scientific Reports, 6, Article No. 31990. [Google Scholar] [CrossRef] [PubMed]
[23] Ozarslan, S., Sevik, H. and Sorar, I. (2019) Microstructure, Mechanical and Corrosion Properties of Novel Mg-Sn-Ce Alloys Produced by High Pressure Die Casting. Materials Science and Engi-neering: C, 105, Article No. 110064. [Google Scholar] [CrossRef] [PubMed]
[24] Li, T., Wang, X.-T., Tang, S.-Q., et al. (2021) Improved Wear Resistance of Biodegradable Mg−1.5Zn−0.6Zr Alloy by Sc Addition. Rare Metals, 40, 2206-2212. [Google Scholar] [CrossRef
[25] Munir, K., Lin, J., Wen, C., et al. (2020) Mechanical, Corrosion, and Biocompatibility Properties of Mg-Zr-Sr-Sc Alloys for Biodegradable Implant Applications. Acta Biomaterialia, 102, 493-507. [Google Scholar] [CrossRef] [PubMed]
[26] Brar, H.S., Ball, J.P., Berglund, I.S., et al. (2013) A Study of a Biodegradable Mg-3Sc-3Y Alloy and the Effect of Self-Passivation on the in Vitro Degradation. Acta Biomaterialia, 9, 5331-5340. [Google Scholar] [CrossRef] [PubMed]
[27] Ding, Y., Lin, J., Wen, C., et al. (2018) Mechanical Properties, Corrosion, and Biocompatibility of Mg-Zr-Sr-Dy Alloys for Biodegradable Implant Applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106, 2425-2434. [Google Scholar] [CrossRef] [PubMed]
[28] Plaass, C., Von Falck, C., Ettinger, S., et al. (2018) Bioabsorbable Mag-nesium versus Standard Titanium Compression Screws for Fixation of Distal Metatarsal Osteotomies—3 Year Results of a Randomized Clinical Trial. Journal of Orthopaedic Science, 23, 321-327. [Google Scholar] [CrossRef] [PubMed]
[29] Klauser, H. (2019) Internal Fixation of Three-Dimensional Distal Metatarsal I Osteotomies in the Treatment of Hallux Valgus Deformities Using Biodegradable Magnesium Screws in Comparison to Titanium Screws. Foot and Ankle Surgery, 25, 398-405. [Google Scholar] [CrossRef] [PubMed]
[30] Kose, O., Turan, A., Unal, M., et al. (2018) Fixation of Medial Mal-leolar Fractures with Magnesium Bioabsorbable Headless Compression Screws: Short-Term Clinical and Radiological Outcomes in Eleven Patients. Archives of Orthopaedic and Trauma Surgery, 138, 1069-1075. [Google Scholar] [CrossRef] [PubMed]
[31] Turan, A., Kati, Y.A., Acar, B., et al. (2020) Magnesium Bioab-sorbable Screw Fixation of Radial Styloid Fractures: Case Report. Journal of Wrist Surgery, 9, 150-155. [Google Scholar] [CrossRef] [PubMed]
[32] Weng, W., Biesiekierski, A., Li, Y., et al. (2021) A Review of the Physiological Impact of Rare Earth Elements and Their Uses in Biomedical Mg Alloys. Acta Biomaterialia, 130, 80-97. [Google Scholar] [CrossRef] [PubMed]