阿尔茨海默病伴抑郁患者血清指标与认知的相关性

Correlation between Serum Markers and Cognition in Alzheimer’s Disease Patients with Depression

摘要: 目的：分析血清脑源性神经营养因子(BDNF)、炎症因子在阿尔茨海默病(AD)伴抑郁患者中的表达及其与认知功能的相关性。方法：选取65例AD患者为研究组，其中AD伴抑郁患者为AD + D组，AD不伴抑郁患者为AD组，另选取45例健康体检者为NC组，采用简易智力检查量表(MMSE)评估受试者的认知功能，检测三组血清BDNF、IL-1β、IL-6和TNF-α水平。结果：与NC组和AD组相比，AD + D组血清BDNF显著降低，血清IL-1β、IL-6和TNF-α显著升高，差异有统计学意义(P < 0.05)。AD组MMSE评分与血清IL-6水平呈负相关(r = 0.481, P < 0.05)，但是与IL-1β、TNF-α和BDNF水平无明显相关性(r = −0.194, −0.212, −0.324, P > 0.05)；AD + D组MMSE评分与血清IL-1β、IL-6和TNF-α水平呈负相关(r = −0.469, −0.603, −0.499, P < 0.05)，与血清BDNF呈正相关(r = 0.738, P < 0.05)。AD组血清BDNF与IL-6呈负相关(r = −0.497, P < 0.05)，与IL-1β和TNF-α无明显相关性(r = −0.233, −0.087, P > 0.05)；AD + D组血清BDNF水平与IL-1β、IL-6和TNF-α水平呈负相关(r = −0.426, −0.741, −0.481, P < 0.05)。结论：阿尔茨海默病伴抑郁患者血清BDNF与炎症因子有一定的相关性，并且可能与认知功能障碍存在紧密联系。

Abstract: Objective: To analyze the expressions of serum brain-derived neurotrophic factor (BDNF) and in-flammatory factors in Alzheimer’s disease patients with depression and their correlation with cog-nitive function. Methods: A total of 65 Alzheimer’s disease patients were selected as the research group, divided into Alzheimer’s disease group and Alzheimer’s disease with depression group ac-cording to whether or not with depression, and 45 healthy subjects were selected as the control group during the same period. The subjects’ cognitive function was assessed using the Mini-Mental State Examination Scales (MMSE). Serum levels of BDNF, IL-1β, IL-6 and TNF-α were detected in all subjects. Results: Compared with the control group and Alzheimer’s disease group, the serum BDNF in the Alzheimer’s disease with depression group was significantly decreased, and the serum IL-1β, IL-6 and TNF-α were significantly increased, and the differences were statistically significant (P < 0.05). The MMSE score in Alzheimer’s disease group was negatively correlated with serum IL-6 level (r = 0.481, P < 0.05), but not significantly correlated with serum IL-1β, TNF-α and BDNF levels (r = −0.194, −0.212, 0.324, P > 0.05). The MMSE score in Alzheimer’s disease with depression group was negatively correlated with serum IL-1β, IL-6 and TNF-α levels (r = −0.469, −0.603, −0.499, P < 0.05), and positively correlated with serum BDNF (r = 0.738, P < 0.05). Serum BDNF in Alzheimer’s dis-ease group was negatively correlated with IL-6 (r = −0.497, P < 0.05), but not significantly correlat-ed with IL-1β and TNF-α (r = −0.233, −0.087, P > 0.05). The serum BDNF level in Alzheimer’s disease with depression group was negatively correlated with the levels of IL-1β, IL-6 and TNF-α (r = −0.426, −0.741, −0.481, P < 0.05). Conclusion: Serum BDNF in patients with Alzheimer’s disease and de-pression may have a certain correlation with inflammatory factors, and may be closely related to cognitive dysfunction.