PD-L1检测方法及研究进展

PD-L1 Detection Methods and Research Progress

摘要: 近年来，肿瘤免疫疗法取得巨大进展，相比其他类型的治疗方法，免疫疗法能够提供持久的疗效，引起更少的副作用。鉴于针对PD-1/PD-L1通路的免疫治疗在不同类型肿瘤以及不同个体间的疗效存在差异，寻找能够预测PD-L1的检验方法成为研究热点。本文回顾分析了不同平台PD-L1的检测特点和临床应用，并总结了PD-L1在不同肿瘤的应答率。

Abstract: In recent years, tumor immunotherapy has made great progress, compared with other types of treatments, immunotherapy can provide long-lasting efficacy, causing fewer side effects. In view of the difference in the efficacy of immunotherapy for the PD-1/PD-L1 pathway in different types of tumors and between different individuals, finding a test method that can predict PD-L1 has become a research hotspot. In this paper, the detection characteristics and clinical application of PD-L1 on different platforms are reviewed and analyzed, and the response rate of PD-L1 in different tumors is summarized.