抑郁患者药物干预的功能性近红外光谱成像研究
Functional Near-Infrared Spectroscopy Imaging Research of Drug Intervention in Depressed Patients
DOI: 10.12677/AP.2022.129398, PDF,    国家自然科学基金支持
作者: 张赫男*, 曹佳丽, 王翠红, 王午阳, 巴 图, 张昊新：内蒙古自治区赤峰市安定医院，内蒙古 赤峰；边越然*, 张 妍#：华中科技大学教育科学研究院，湖北 武汉；王桂香：武汉东湖学院，湖北 武汉；任虹霖#：武汉软件工程职业学院，湖北 武汉
关键词: 抑郁症；药物干预；功能性近红外光谱；言语流畅性任务；Depression； Drug Intervention； Functional Near-Infrared Spectroscopy； VFT Task
摘要: 目的：应用37近红外光谱仪，研究抑郁患者在言语流畅性任务下脑血氧信号变化的差异和特征，探索药物干预治疗抑郁症的神经机制。方法：本研究共52名被试，分为23例抑郁组和29例正常对照组，对照组进行一个月的常规药物治疗，正常对照组不进行任何治疗，评估2组干预前后言语流畅性任务下血氧信号、睡眠质量及抑郁症状。结果：在前测评分中，抑郁组在右侧额极区的平均脱氧血红蛋白指标显著大于正常对照组[(−0.04 ± 0.04) vs. (−0.07 ± 0.05), P = 0.04]，在右侧背外侧前额叶的氧合血红蛋白峰值指标趋于显著小于正常对照组[(0.15 ± 0.09) vs. (0.26 ± 0.24), P = 0.06]。经过药物干预后，抑郁组与正常对照组各指标无显著差异(均P > 0.05)。与问卷进行相关分析结果显示，进行药物干预后，额极区平均氧合血红蛋白指标(睡眠质量r = 0.54, P = 0.01、抑郁症状r = 0.53, P = 0.01)的下降、右侧额极区平均脱氧血红蛋白指标(抑郁症状r = −0.58, P = 0.003)的上升、右侧背外侧前额叶平均氧合血红蛋白指标(睡眠质量r = 0.52, P = 0.01)的下降与临床改善相关。结论：药物干预后，抑郁患者与健康群体在脑激活程度上无显著差异。右侧背外侧前额叶及额极区激活程度降低与抑郁症症状改善相关。
Abstract: Objective: The study used 37 near-infrared spectroscopy to study the differences and characteristics of cerebral blood oxygen signal changes in depressed patients under the verbal fluency task and to explore the neural mechanism of drug intervention in treating depression. Methods: There are 52 participants in this study, who were divided into 23 cases in the depression group and 29 cases in the control group. The experimental group received routine drug treatment for one month, while the control group did not receive any treatment. The study evaluated the blood oxygen signal, sleep quality, and depressive symptoms before and after the intervention. Results: In the pre-test, Avg-HbR in the R_FP was significantly larger than that of the control group [(−0.04 ± 0.04) vs. (−0.07 ± 0.05), P = 0.04], and Peak-HbO of the R_DLPFC was significantly smaller than that of the control group [(0.15 ± 0.09) vs. (0.26 ± 0.24), P = 0.06]. After drug intervention, there was no significant difference between the experimental group and the control group (all P > 0.05). The results of correlation analysis with the questionnaire showed that after drug intervention, the decline of Avg-HbO in the FP (sleep quality r = 0.54, P = 0.01; depressive symptoms r = 0.53, P = 0.01), the rise of Avg-HbR in the R_FP (depressive symptoms r = −0.58, P = 0.003), and the decrease of Avg-HbO in R_DLPFC (sleep quality r = 0.52, P = 0.01) were related to clinical improvement. Conclusion: After drug intervention, there was no significant difference in brain activation between depressed patients and healthy groups. Lower activation of R_DLPFC and FP was associated with improved symptoms of depression.
文章引用：张赫男, 边越然, 王桂香, 曹佳丽, 王翠红, 王午阳, 巴图, 张昊新, 张妍, 任虹霖 (2022). 抑郁患者药物干预的功能性近红外光谱成像研究. 心理学进展, 12(9), 3284-3292. https://doi.org/10.12677/AP.2022.129398

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