血清、脑脊液降钙素原与神经外科中枢神经系统感染的研究进展

Research Progress of Serum, Cerebrospinal Fluid Procalcitonin and Neurosurgical Central Nervous System Infections

摘要: 神经外科中枢神经系统感染(neurosurgical central nervous system infections, NCNSIs)是包括颅内和椎管内的感染，而颅内感染是神经外科术后严重并发症之一，最常见为细菌性颅内感染。相关证据显示NCNSIs发病率呈上升趋势，发病后病情凶险，治疗难度大，致残率和致死率较高。研究表明对患者进行早诊断、早治疗可以明显改善预后，减少不良结局。中枢神经系统感染临床表现及影像学特异性差，脑脊液病原菌培养周期相对较长、阳性率低，难以及时、准确判断病情，容易错失最佳治疗时期。因此寻求一种便捷、高效的检测方法，对于疾病的早期诊断及治疗至关重要。本文对目前研究报道中关于血清、脑脊液中降钙素原(Procalcitonin, PCT)在NCNSIs中的作用进行总结，为临床诊治提供参考。

Abstract: Neurosurgical central nervous system infections (NCNSIs) include intracranial and spinal canal in-fections. Intracranial infections are one of the serious complications after neurosurgery, and the most common one is bacterial intracranial infections. Relevant evidence shows that the incidence of NCNSIs is on the rise, the disease is dangerous, the treatment is difficult, and the disability rate and mortality rate are high. Studies have shown that early diagnosis and treatment of patients can sig-nificantly improve the specificity of central nervous system infection are poor, the culture cycle of cerebrospinal fluid pathogens is relatively long, the positive rate is low, it is difficult to judge the condition in time and accurately, and it is easy to miss the best treatment period. Therefore, seek-ing a convenient and efficient detection method is very important for the early diagnosis and treatment of the disease. This paper summarizes the role of procalcitonin in serum and cerebro-spinal fluid (PCT) in NCNSIs, so as to provide reference for clinical diagnosis and treatment.