黑磷在抗肿瘤治疗中的新进展
New Progress of Black Phosphorus in Antitumor Therapy
DOI: 10.12677/ACM.2022.12101306, PDF,   
作者: 曾 沛, 王 军, 梁华庚*：华中科技大学同济医学院附属协和医院，湖北 武汉
关键词: 黑磷；抗肿瘤治疗；纳米药物；新进展；Black Phosphorus； Antitumor Therapy； Nanomedicine； New Progress
摘要: 肿瘤是威胁人类生命健康的主要威胁之一。目前，由于靶向性低，耐受性差、并发症多，副作用大等缺陷，传统的抗肿瘤疗法面临着许多瓶颈。为了解决这些问题并提高治疗效率，新型的抗肿瘤纳米药物受到了人们广泛的关注，黑磷作为一种抗肿瘤纳米药，凭借其出色的光热、光动力和可降解特性被认为是新一代纳米药物治疗载药平台的有力竞争者。本综述回顾了当前肿瘤治疗的现状以及存在的缺陷，并总结了黑磷纳米片的合成方法、特性及其在肿瘤治疗中的新进展。
Abstract: Tumor is one of the main threats to human life and health. At present, traditional anti-tumor ther-apy faces many bottlenecks due to its low targeting, poor tolerance, many complications, and strong side effects. In order to solve these problems and improve the therapeutic efficiency, novel an-ti-tumor nano-drugs have received extensive attention. As an anti-tumor nano-drug, black phos-phorus is considered to be a new generation of anti-tumor nano-drugs and a strong contender for nanomedicine therapeutic drug delivery platforms due to its excellent photothermal, photodynam-ic and degradable properties. This article reviews the current status and defects of current tumor therapy, and summarizes the synthesis methods, properties and new progress of black phosphorus nanosheets in tumor therapy.
文章引用：曾沛, 王军, 梁华庚. 黑磷在抗肿瘤治疗中的新进展[J]. 临床医学进展, 2022, 12(10): 9030-9036. https://doi.org/10.12677/ACM.2022.12101306

参考文献

[1] Siegel, R.L., Miller, K.D., Fuchs, H.E. and Jemal, A. (2021) Cancer Statistics, 2021. CA: A Cancer Journal for Clini-cians, 71, 7-33. [Google Scholar] [CrossRef] [PubMed]
[2] Organ, C.H. and Bold, R.J. (1996) Surgery. JAMA, 275, 1855-1857. [Google Scholar] [CrossRef] [PubMed]
[3] Weingart, S.N., Zhang, L., Sweeney, M. and Hassett, M. (2018) Chemotherapy Medication Errors. The Lancet Oncology, 19, e191-e199. [Google Scholar] [CrossRef] 
[4] Shanmugam, V., Selvakumar, S. and Yeh, C.-S. (2014) Near-Infrared Light-Responsive Nanomaterials in Cancer Therapeutics. Chemical Society Reviews, 43, 6254-6287. [Google Scholar] [CrossRef] 
[5] Zingg, R. and Fischer, M. (2019) The Consolidation of Nanomedicine. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 11, e1569. [Google Scholar] [CrossRef] [PubMed]
[6] Yoo, J.M., Kang, J.H. and Hong, B.H. (2015) Graphene-Based Nano-materials for Versatile Imaging Studies. Chemical Society Reviews, 44, 4835-4852. [Google Scholar] [CrossRef] 
[7] Wang, S., Chen, Y., Li, X., Gao, W., Zhang, L., Liu, J., Zheng, Y., Chen, H. and Shi, J. (2015) Injectable 2D MoS2- Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia. Advanced Materials (Deerfield Beach, Fla.), 27, 7117-7122. [Google Scholar] [CrossRef] [PubMed]
[8] Mrejen, M., Yadgarov, L., Levanon, A. and Suchowski, H. (2019) Transient Exciton-Polariton Dynamics in WSe by Ultrafast Near-Field Imaging. Science Advances, 5, eaat9618. [Google Scholar] [CrossRef] [PubMed]
[9] Liu, J., Zheng, T. and Tian, Y. (2019) Functionalized h-BN Nanosheets as a Theranostic Platform for SERS Real-Time Monitoring of MicroRNA and Photodynamic Therapy. Angewandte Chemie International Edition, 58, 7757-7761. [Google Scholar] [CrossRef] [PubMed]
[10] Lin, H., Gao, S., Dai, C., Chen, Y. and Shi, J. (2017) A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows. Journal of the American Chemical Society, 139, 16235-16247. [Google Scholar] [CrossRef] [PubMed]
[11] Zhi, D., Yang, T., O’Hagan, J., Zhang, S. and Donnelly, R.F. (2020) Photothermal Therapy. Journal of Controlled Release: Official Journal of the Controlled Release Society, 325, 52-71. [Google Scholar] [CrossRef] [PubMed]
[12] Dong, W., Li, Y., Niu, D., Ma, Z., Gu, J., Chen, Y., Zhao, W., Liu, X., Liu, C. and Shi, J. (2011) Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy. Advanced Materials (Deerfield Beach, Fla.), 23, 5392-5397. [Google Scholar] [CrossRef] [PubMed]
[13] Liu, S., Pan, X. and Liu, H. (2020) Two-Dimensional Nanomaterials for Photothermal Therapy. Angewandte Chemie International Edition, 59, 5890-5900. [Google Scholar] [CrossRef] [PubMed]
[14] Yang, B., Chen, Y. and Shi, J. (2019) Reactive Oxygen Species (ROS)-Based Nanomedicine. Chemical Reviews, 119, 4881-4985. [Google Scholar] [CrossRef] [PubMed]
[15] Liang, J. and Liu, B. (2016) ROS-Responsive Drug Delivery Systems. Bioengineering & Translational Medicine, 1, 239-251. [Google Scholar] [CrossRef] [PubMed]
[16] Soldevila-Barreda, J.J. and Metzler-Nolte, N. (2019) Intracellular Cataly-sis with Selected Metal Complexes and Metallic Nanoparticles: Advances toward the Development of Catalytic Metal-lodrugs. Chemical Reviews, 119, 829-869. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, H., Neal, A.T., Zhu, Z., Luo, Z., Xu, X., Tománek, D. and Ye, P.D. (2014) Phosphorene: An Unexplored 2D Semiconductor with a High Hole Mobility. ACS Nano, 8, 4033-4041. [Google Scholar] [CrossRef] [PubMed]
[18] Zhu, X., Ji, X., Kong, N., Chen, Y., Mahmoudi, M., Xu, X., Ding, L., Tao, W., Cai, T., Li, Y., Gan, T., Barrett, A., Bharwani, Z., Chen, H. and Farokhzad, O.C. (2018) Intracellular Mechanistic Understanding of 2D MoS Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy. ACS Nano, 12, 2922-2938. [Google Scholar] [CrossRef] [PubMed]
[19] Chen, P., Zhang, Z., Duan, X. and Duan, X. (2018) Chemical Syn-thesis of Two-Dimensional Atomic Crystals, Heterostructures and Superlattices. Chemical Society Reviews, 47, 3129-3151. [Google Scholar] [CrossRef] 
[20] Geim, A.K. and Novoselov, K.S. (2007) The Rise of Gra-phene. Nature Materials, 6, 183-191. [Google Scholar] [CrossRef] [PubMed]
[21] Zhu, Y., Wang, Y., Williams, G.R., Fu, L., Wu, J., Wang, H., Liang, R., Weng, X. and Wei, M. (2020) Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging-Guided Pho-tothermal and Chemodynamic Therapy. Advanced Materials, 7, Article ID: 2000272. [Google Scholar] [CrossRef] [PubMed]
[22] Radisavljevic, B., Radenovic, A., Brivio, J., Giacometti, V. and Kis, A. (2011) Single-Layer MoS2 Transistors. Nature Nanotechnology, 6, 147-150. [Google Scholar] [CrossRef] [PubMed]
[23] Lembke, D., Bertolazzi, S. and Kis, A. (2015) Single-Layer MoS2 Electronics. Accounts of Chemical Research, 48, 100-110. [Google Scholar] [CrossRef] [PubMed]
[24] Cheng, L., Wang, X., Gong, F., Liu, T. and Liu, Z. (2020) 2D Nanomaterials for Cancer Theranostic Applications. Advanced Materials (Deerfield Beach, Fla.), 32, e1902333. [Google Scholar] [CrossRef] [PubMed]
[25] Anju, S., Ashtami, J. and Mohanan, P.V. (2019) Black Phosphorus, a Prospective Graphene Substitute for Biomedical Applications. Materials Science & Engineering C—Materials for Biological Applications, 97, 978-993. [Google Scholar] [CrossRef] [PubMed]
[26] Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X.-B. and Tan, W. (2016) A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photody-namic Therapy by Reducing Glutathione Levels in Cancer Cells. Angewandte Chemie International Edition, 55, 5477-5482. [Google Scholar] [CrossRef] [PubMed]
[27] Qu, G., Xia, T., Zhou, W., Zhang, X., Zhang, H., Hu, L., Shi, J., Yu, X.-F. and Jiang, G. (2020) Property-Activity Relationship of Black Phosphorus at the Nano-Bio Interface: From Molecules to Organisms. Chemical Reviews, 120, 2288-2346. [Google Scholar] [CrossRef] [PubMed]
[28] Ambrosi, A., Sofer, Z. and Pumera, M. (2017) Electrochemical Exfoliation of Layered Black Phosphorus into Phosphorene. Angewandte Chemie International Edition, 56, 10443-10445. [Google Scholar] [CrossRef] [PubMed]
[29] Shao, J., Xie, H., Huang, H., Li, Z., Sun, Z., Xu, Y., Xiao, Q., Yu, X.-F., Zhao, Y., Zhang, H., Wang, H. and Chu, P.K. (2016) Biodegradable Black Phosphorus-Based Nanospheres for in Vivo Photothermal Cancer Therapy. Nature Communications, 7, Article No. 12967. [Google Scholar] [CrossRef] [PubMed]
[30] Liu, J., Du, P., Mao, H., Zhang, L., Ju, H. and Lei, J. (2018) Du-al-Triggered Oxygen Self-Supply Black Phosphorus Nanosystem for Enhanced Photodynamic Therapy. Biomaterials, 172, 83-91. [Google Scholar] [CrossRef] [PubMed]
[31] Liu, Y., Bhattarai, P., Dai, Z. and Chen, X. (2019) Photo-thermal Therapy and Photoacoustic Imaging via Nanotheranostics in Fighting Cancer. Chemical Society Reviews, 48, 2053-2108. [Google Scholar] [CrossRef] 
[32] Wang, H., Yang, X., Shao, W., Chen, S., Xie, J., Zhang, X., Wang, J. and Xie, Y. (2015) Ultrathin Black Phosphorus Nanosheets for Efficient Singlet Oxygen Generation. Journal of the American Chemical Society, 137, 11376-11382. [Google Scholar] [CrossRef] [PubMed]
[33] Plutnar, J., Sofer, Z. and Pumera, M. (2018) Products of Degradation of Black Phosphorus in Protic Solvents. ACS Nano, 12, 8390-8396. [Google Scholar] [CrossRef] [PubMed]
[34] Zhang, T., Wan, Y., Xie, H., Mu, Y., Du, P., Wang, D., Wu, X., Ji, H. and Wan, L. (2018) Degradation Chemistry and Stabilization of Exfoliated Few-Layer Black Phosphorus in Water. Journal of the American Chemical Society, 140, 7561-7567. [Google Scholar] [CrossRef] [PubMed]
[35] Abellán, G., Wild, S., Lloret, V., Scheuschner, N., Gillen, R., Mundloch, U., Maultzsch, J., Varela, M., Hauke, F. and Hirsch, A. (2017) Fundamental Insights into the Degradation and Stabilization of Thin Layer Black Phosphorus. Journal of the American Chemical Society, 139, 10432-10440. [Google Scholar] [CrossRef] [PubMed]
[36] Guo, L., Panderi, I., Yan, D.D., Szulak, K., Li, Y., Chen, Y.-T., Ma, H., Niesen, D.B., Seeram, N., Ahmed, A., Yan, B., Pantazatos, D. and Lu, W. (2013) A Comparative Study of Hollow Copper Sulfide Nanoparticles and Hollow Gold Nanospheres on Degra-dability and Toxicity. ACS Nano, 7, 8780-8793. [Google Scholar] [CrossRef] [PubMed]
[37] Shao, J., Ruan, C., Xie, H., Li, Z., Wang, H., Chu, P.K. and Yu, X.F. (2018) Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Bio-degradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science (Weinh), 5, Article ID: 1700848. [Google Scholar] [CrossRef] [PubMed]
[38] Hu, K., Xie, L., Zhang, Y., Hanyu, M., Yang, Z., Nagatsu, K., Suzuki, H., Ouyang, J., Ji, X., Wei, J., Xu, H., Farokhzad, O.C., Liang, S.H., Wang, L., Tao, W. and Zhang, M.R. (2020) Marriage of Black Phosphorus and Cu(2+) as Effective Photothermal Agents for PET-Guided Combination Can-cer Therapy. Nature Communications, 11, Article No. 2778. [Google Scholar] [CrossRef] [PubMed]
[39] Hu, K.X.L., Zhang, Y., Hanyu, M., Yang, Z., Nagatsu, K., Suzuki, H., Ouyang, J., Ji, X., Wei, J., Xu, H., Farokhzad, O.C., Liang, S.H., Wang, L., Tao, W. and Zhang, M.R. Supplementary Information for Marriage of Black Phosphorus and Cu2+ as Effective Photothermal Agents for PET-Guided Combination Cancer Therapy.
https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-16513-0/MediaObjects/41467_2020_16513_MOESM1_ESM.pdf
[40] Liu, J., Du, P., Liu, T., Cordova Wong, B.J., Wang, W., Ju, H. and Lei, J. (2019) A Black Phosphorus/Manganese Dioxide Nanoplatform: Oxygen Self-Supply Monitoring, Photodynamic Therapy Enhancement and Feedback. Biomaterials, 192, 179-188. [Google Scholar] [CrossRef] [PubMed]
[41] Huang, H., He, L., Zhou, W., Qu, G., Wang, J., Yang, N., Gao, J., Chen, T., Chu, P.K. and Yu, X.F. (2018) Stable Black Phospho-rus/Bi2O3 Heterostructures for Synergistic Cancer Radiotherapy. Biomaterials, 171, 12-22. [Google Scholar] [CrossRef] [PubMed]
[42] Xue, C., Sutrisno, L., Li, M., Zhu, W., Fei, Y., Liu, C., Wang, X., Cai, K., Hu, Y. and Luo, Z. (2021) Implantable Multifunctional Black Phosphorus Nanoformula-tion-Deposited Biodegradable Scaffold for Combinational Photothermal/Chemotherapy and Wound Healing. Biomateri-als, 269, Article ID: 120623. [Google Scholar] [CrossRef] [PubMed]
[43] Chen, W., Ouyang, J., Liu, H., Chen, M., Zeng, K., Sheng, J., Liu, Z., Han, Y., Wang, L., Li, J., Deng, L., Liu, Y.N. and Guo, S. (2017) Black Phosphorus Nanosheet-Based Drug Delivery System for Synergistic Photodynamic/Photothermal/ Chemotherapy of Cancer. Advanced Materials, 29, Article ID: 1603864. [Google Scholar] [CrossRef] [PubMed]
[44] Zhou, W.H., Pan, T., Cui, H.D., Zhao, Z., Chu, P.K. and Yu, X.F. (2019) Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects. Angewandte Chemie International Edition, 58, 769-774. [Google Scholar] [CrossRef] [PubMed]
[45] Wan, L., Pantel, K. and Kang, Y. (2013) Tumor Metastasis: Moving New Biological Insights into the Clinic. Nature Medicine, 19, 1450-1464. [Google Scholar] [CrossRef] [PubMed]

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