罗库溴铵的影响因素及临床应用的研究进展

Research Progress on Influencing Factors and Clinical Application of Rocuronium

摘要: 在临床工作中，我们经常会用到肌松剂来达到临床目的，使患者受到更好的治疗；在全身麻醉中，肌松剂的使用更是必不可少的，它不仅可以为外科手术和机械通气创造便利的条件，而且可以提高某些疾病的治愈效果。快速起效的肌松剂对于患者来说更加安全有效，极大地减少麻醉过深的发生，同时可以满足外科手术的需求，神经肌肉传导功能在手术结束后也会快速恢复，因此肌松残余及不良反应的发生率会显著降低。此外，肌松剂的药效学个体差异非常大，受温度、性别、肥胖、年龄、体重等影响。因此肌松剂的选择以及剂量的合理使用一直是麻醉医生关注的重点。

Abstract: In clinical work, we often use muscle relaxants to achieve clinical purposes, so that patients are better treated; In general anesthesia, the use of muscle relaxants is essential, it can not only create convenient conditions for surgery and mechanical ventilation, but also improve the curative effect of some diseases. Fast-acting muscle relaxants are safer and more effective for patients, which can greatly reduce the occurrence of too deep anesthesia, and meet the needs of surgery. Neuromuscu-lar conduction function will recover quickly after surgery, so the incidence of residual muscle re-laxants and adverse reactions will be significantly reduced. In addition, individual differences in the pharmacodynamics of muscle relaxants are greatly affected by temperature, gender, obesity, age, weight, etc. Therefore, the choice of muscle relaxants and the rational use of dosage have always been the focus of anesthesiologists.