急性胃肠损伤检测进展
Advances in Detection of Acute Gastrointestinal Injury
摘要: 脓毒症、创伤、休克、胰腺炎、急性呼吸窘迫综合征等常见危重疾病均可引起胃肠道功能障碍或衰竭。基于对危重症患者胃肠道功能的逐渐重视，急性胃肠损伤(acute gastrointestinal injury, AGI)的概念被提出。然而目前由于客观证据的缺乏，导致AGI的诊疗策略多是根据临床医生的临床经验制定的。在此，作者将急性胃肠道损伤的检测手段做一归纳、分析。
Abstract: Gastrointestinal dysfunction or failure can be caused by common critical diseases such as sepsis, trauma, shock, pancreatitis and acute respiratory distress syndrome. The concept of acute gastro-intestinal injury (AGI) was put forward based on the increasing emphasis on gastrointestinal func-tion of critically ill patients. However, up till now the diagnosis and treatment strategies of AGI are mostly based on the clinical experience of clinicians, due to the lack of objective evidence. In this paper, the author summarizes and analyzes the detection methods of acute gastrointestinal injury.
文章引用：刘银洲, 张安. 急性胃肠损伤检测进展[J]. 临床医学进展, 2022, 12(10): 9261-9266. https://doi.org/10.12677/ACM.2022.12101339

参考文献

[1] Meng, M., Klingensmith, N.J. and Coopersmith, C.M. (2017) New Insights into the Gut as the Driver of Critical Illness and Organ Failure. Current Opinion in Critical Care, 23, 143-148. [Google Scholar] [CrossRef] 
[2] Sonja, F. and Johann, K. (2010) Effect of ICU Interven-tions on Gastrointestinal Motility. Current Opinion in Critical Care, 16, 159-164. [Google Scholar] [CrossRef] 
[3] Abimbola, A. and Quigley, E.M.M. (2014) Gastrointestinal Motility Problems in Critical Care: A Clinical Perspective. Journal of Digestive Diseases, 15, 335-344. [Google Scholar] [CrossRef] [PubMed]
[4] Hartmann, M., Montgomery, A., Jönsson, K., et al. (1991) Tissue Oxygenation in Hemorrhagic Shock Measured as Transcutaneous Oxygen Tension, Subcutaneous Oxygen Tension, and Gastrointestinal Intramucosal pH in Pigs. Critical Care Medicine, 19, 205-210. [Google Scholar] [CrossRef] [PubMed]
[5] Fiddian-Green, R.G., McGough, E., Pittenger, G., et al. (1983) Predictive Value of Intramural pH and Other Risk Factors for Massive Bleeding from Stress Ulceration. Gastro-enterology, 85, 613-620. [Google Scholar] [CrossRef] [PubMed]
[6] Upadhyay, K.K., Singh, V.P. and Murthy, T. (2007) Gastric Tonometry as a Prognostic Index of Mortality in Sepsis. Medical Journal Armed Forces India, 63, 337-340. [Google Scholar] [CrossRef] 
[7] Gutierrez, G., Palizas, F., Doglio, G., et al. (1992) Gastric Intramucosal pH as a Therapeutic Index of Tissue Oxygenation in Critically Ill Patients. The Lancet, 339, 195-199. [Google Scholar] [CrossRef] 
[8] van Haren, F.M., Sleigh, J.W., Pickkers, P. and Van der Hoeven, J.G. (2007) Gastrointestinal Perfusion in Septic Shock. Anaesthesia and Intensive Care, 35, 679-694. [Google Scholar] [CrossRef] 
[9] Ramirez, F.C., Sukhdeep, P., Susan, M., et al. (2002) Reflec-tance Spectrophotometry in the Gastrointestinal Tract: Limitations and new applications. American Journal of Gastroen-terology, 97, 2780-2784. [Google Scholar] [CrossRef] [PubMed]
[10] Fournell, A., Schwarte, L.A., Kindgen-Milles, D., et al. (2003) Assessment of Microvascular Oxygen Saturation in Gastric Mucosa in Volunteers Breathing Continuous Positive Airway Pressure. Critical Care Medicine, 31, 1705-1710. [Google Scholar] [CrossRef] 
[11] 孙继成, 马进, 沈超, 等. 近红外光谱技术(NIRS)在人体的应用与展望[J]. 现代生物医学进展, 2016, 16(8): 1594-1597. DOI:10.13241/j.cnki.pmb.2016.08.047
[12] Cohn, S.M., Varela, J.E., Giannotti, G., et al. (2001) Splanchnic Perfusion Evaluation during Hemorrhage and Resuscitation with Gastric Near-Infrared Spectroscopy. The Journal of Trauma, 50, 629-634. [Google Scholar] [CrossRef] [PubMed]
[13] Jacquet-Lagrèze, M., Bonnet-Garin, J.-M., Allaouchiche, B., et al. (2014) A New Device for Continuous Assessment of Gut Perfusion: Proof of Concept on a Porcine Model of Septic Shock. Critical Care, 18, R153. [Google Scholar] [CrossRef] [PubMed]
[14] Maurer, A., Abell, T., Bennett, P., et al. (2020) Appropriate Use Criteria for Gastrointestinal Transit Scintigraphy. Journal of Nuclear Medicine, 61, 11N-17N.
[15] Parkman, H.P. (2009) Assess-ment of Gastric Emptying and Small-Bowel Motility: Scintigraphy, Breath Tests, Manometry, and SmartPill. Gastroin-testinal Endoscopy Clinics of North America, 19, 49-55. [Google Scholar] [CrossRef] [PubMed]
[16] Szarka, L.A. and Camilleri, M. (2009) Methods for Measurement of Gastric Motility. The American Journal of Physiology-Gastrointestinal and Liver Physiology, 296, G461-G475. [Google Scholar] [CrossRef] [PubMed]
[17] Camps, G., Mars, M., Witteman, B.J.M., et al. (2018) Indirect vs Direct Assessment of Gastric Emptying: A Randomized Crossover Trial Comparing C-Isotope Breath Analysis and MRI. Neurogastroenterology & Motility, 30, e13317. [Google Scholar] [CrossRef] [PubMed]
[18] Usai-Satta, P., Oppia, F., Lai, M., et al. (2021) Hydrogen Breath Tests: Are They Really Useful in the Nutritional Management of Digestive Disease? Nutrients, 13, Article No. 974. [Google Scholar] [CrossRef] [PubMed]
[19] Braden, B. (2009) Methods and Functions: Breath Tests. Best Practice & Research Clinical Gastroenterology, 23, 337- 352. [Google Scholar] [CrossRef] [PubMed]
[20] Wang, J., Yu, L.M., Xia, Y.H., et al. (2017) Diagnostic Value of Citrulline and Intestinal Fatty Acid Binding Protein on Acute Gastro-intestinal Injury in Critical Patients: A Prospective Study of 530 Patients. Chinese Critical Care Medicine, 29, 999-1003.
[21] Blaser, A., Padar, M., Tang, J., Dutton, J. and Forbes, A. (2019) Citrulline and Intestinal Fatty Ac-id-Binding Protein as Biomarkers for Gastrointestinal Dysfunction in the Critically Ill. Anaesthesiology Intensive Therapy, 51, 230-239. [Google Scholar] [CrossRef] [PubMed]
[22] Levitt, M.D. and Levitt, D.G. (2020) Quantitative Evaluation of D-Lactate Pathophysiology: New Insights into the Mechanisms Involved and the Many Areas in Need of Further Inves-tigation. Clinical and Experimental Gastroenterology, 13, 321-337. [Google Scholar] [CrossRef] 
[23] Ewaschuk, J.B., Naylor, J.M. and Zello, G.A. (2005) D-Lactate in Human and Ruminant Metabolism. The Journal of Nutrition, 135, 1619-1625. [Google Scholar] [CrossRef] [PubMed]
[24] 程源, 徐鹏远. D-乳酸与I-FABP在肠屏障功能受损中作用的研究进展[J]. 中国临床新医学, 2018, 11(9): 949-953.
[25] Li, H.X., Chen, Y., Huo, F.F., et al. (2017) Association be-tween Acute Gastrointestinal Injury and Biomarkers of Intestinal Barrier Function in Critically Ill Patients. BMC Gastro-enterology, 17, Article No. 45. [Google Scholar] [CrossRef] [PubMed]
[26] Teng, J., Xiang, L., Long, H.C., et al. (2021) The Serum Citrulline and D-Lactate Are Associated with Gastrointestinal Dysfunction and Failure in Critically Ill Patients. International Jour-nal of General Medicine, 14, 4125-4134. [Google Scholar] [CrossRef] 
[27] 刘玉, 赵严, 刘苏, 刘占举. 肠型脂肪酸结合蛋白在急性胰腺炎早期肠屏障损伤中的临床诊断价值[J]. 国际消化病杂志, 2013, 33(5): 329-330+349.
[28] Guerville, M. and Bou-dry, G. (2016) Gastrointestinal and Hepatic Mechanisms Limiting Entry and Dissemination of Lipopolysaccharide into the Systemic Circulation. The American Journal of Physiology-Gastrointestinal and Liver Physiology, 311, G1-G15.
[29] Okada, K., Sekino, M., Funaoka, H., et al. (2018) Intestinal Fatty Acid-Binding Protein Levels in Patients with Chronic Renal Failure. Journal of Surgical Research, 230, 94-100.
[30] Schellekens, D.H., Hundscheid, I.H., Leenarts, C.A., et al. (2017) Human Small Intestine Is Capable of Restoring Barrier Function after Short Ischemic Peri-ods. World Journal of Gastroenterology, 23, 8452-8464.

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