妊娠期小肠细菌过度生长对孕妇血脂代谢及并发症的影响

The Effect of Gestation Small Intestinal Bacteria Overgrowth on Maternal Blood Lipid Metabolism and Complications

摘要: 目的：探讨妊娠期小肠细菌过度生长(small intestinal bacteria overgrowth, SIBO)对孕妇血脂代谢水平及并发症的影响。方法：筛选2020年2月~2022年2月来我院进行体检的85例孕妇作为研究对象，根据氢和甲烷呼气试验检测结果分为病例组(n = 34)与参照组(n = 51)，检测与统计两组的各项血脂指标水平及并发症发生情况。结果：两组孕妇的SF、TC、TG、LDL-C、HDL-C、APO-B及FFA值存在显著差异(P < 0.05)；多因素Logistic回归分析结果显示：TC、TG、LDL-C、HDL-C是导致妊娠期孕妇发生SIBO的独立影响因素；线性拟合分析发现，呼气H2浓度值与TC、TG及LDL-C值呈正相关(R2 = 0.779, 0.602, 0.820)，与HDL-C值呈负相关(R2 = 0.614)；病例组孕妇的并发症总发生率显著高于参照组(P < 0.05)。结论：妊娠期SIBO可能会导致孕妇血脂代谢水平发生异常，并诱发多种并发症的出现，及时诊治SIBO，对改善分娩结局、促进胎儿的正常生长发育具有重要意义。

Abstract: Objective: To investigate the effect of gestation small intestinal bacteria overgrowth (SIBO) on ma-ternal blood lipid metabolism and complications. Methods: 85 pregnant women for physical exam-ination from February 2020 to February 2022 were selected as research subjects. According to the hydrogen and methane breath test results, the research subjects were divided into case group (n = 34) and reference group (n = 51), the level of blood lipid indicators and complications of the two groups were detected and counted. Results: SF, TC, TG, LDL-C, HDL-C, APO-B and FFA values signifi-cantly between the two groups (P < 0.05); The results of the multivariate Logistic regression analy-sis showed that TC, TG, LDL-C and HDL-C were the independent factors affecting the maternal SIBO in pregnancy; Linear-fitting analysis found that expiratory H2 concentrations positively correlated with TC, TG and LDL-C values (R2 = 0.779, 0.602, 0.820), negative correlation with HDL-C values (R2 = 0.614); The overall incidence of maternal complications was significantly higher in the case group than in the reference group (P < 0.05). Conclusion: SIBO during pregnancy may lead to abnormal maternal blood lipid metabolism level, and induce the emergence of various complications. Timely diagnosis and treatment of SIBO is of great significance to improve the delivery outcome and pro-mote the normal growth and development of the fetus.