红景天苷控制近视进展作用可行性分析
Feasibility of Salidroside in Controlling Myopia Progression
DOI: 10.12677/ACM.2022.12101356, PDF,    科研立项经费支持
作者: 赵 爽*：山东第一医科大学(山东省医学科学院)，山东 济南；张娟美*, 赵 军：临沂市人民医院眼科，山东 临沂；许莞菁：青岛大学青岛医学院，山东 青岛；郑凌方：潍坊医学院，山东 潍坊；付艺璇：锦州医科大学，辽宁 锦州
关键词: 近视；红景天苷；抗缺氧机制；缺氧诱导因子；多巴胺；Myopia； Salidroside； Anti-Anoxia Mechanism； Hypoxia-Inducing Factor 1α； Dopamine
摘要: 红景天苷是从景天科植物大株红景天的干燥根及根茎或干燥全草中提取出的一种化合物，在多种神经系统疾病中如阿尔茨海默病、帕金森病、重度抑郁症、创伤性颅脑损伤及缺血性脑损伤等，呼吸系统疾病如肺动脉高压、肺组织纤维化、慢性阻塞性肺疾病等均有大量研究使用，在护肝、抗肿瘤、抗病毒等方面也有一定应用。最新研究提示巩膜缺氧重塑、视网膜多巴胺含量和脉络膜血流在近视的进展中发挥重要作用。红景天苷具有抗缺氧、抗氧化应激、抗炎及抑制凋亡等药理活性，通过研究其对脉络膜视网膜缺氧诱导因子1α (hypoxia-inducing factor, HIF-1α)、多巴胺(dopamine, DA)含量的影响，可能为近视进展的控制带来新的选择。
Abstract: Salidroside is a compound extracted from the dried roots, rhizomes or dried whole plants of Rhodi-ola rosea, which has been widely used in a variety of neurological diseases such as Alzheimer’s dis-ease, Parkinson’s disease, major depression, traumatic brain injury and ischemic brain injury, res-piratory diseases such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, and has also been used in liver protection, anti-tumor, and antiviral aspects. Recent studies suggest that scleral hypoxic remodeling, retinal dopamine content, and choroidal blood flow play an important role in the progression of myopia. Salidroside has pharmacological ac-tivities such as anti-hypoxia, anti-oxidative stress, anti-inflammation and inhibition of apoptosis. By studying the effect of salidroside on hypoxia-inducing factor 1α (HIF-1α) and dopamine (DA) content in choroid and retina, it brings new options for the control of myopia progression.
文章引用：赵爽, 张娟美, 赵军, 许莞菁, 郑凌方, 付艺璇. 红景天苷控制近视进展作用可行性分析[J]. 临床医学进展, 2022, 12(10): 9377-9383. https://doi.org/10.12677/ACM.2022.12101356

参考文献

[1] Holden, B.A., Fricke, T.R., Wilson, D.A., et al. (2016) Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology, 123, 1036-1042. [Google Scholar] [CrossRef] [PubMed]
[2] Pan, C.W., Dirani, M., Cheng, C.Y., et al. (2015) The Age-Specific Prevalence of Myopia in Asia: A Meta-Analysis. Optometry and Vision Science, 92, 258-266. [Google Scholar] [CrossRef] 
[3] Tham, Y.C., Aung, T., Fan, Q., et al. (2016) Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Dis-eases Study. Scientific Reports, 6, Article No. 19320. [Google Scholar] [CrossRef] [PubMed]
[4] Frisina, R., Baldi, A., Cesana, B.M., et al. (2016) Morphological and Clin-ical Characteristics of Myopic Posterior Staphyloma in Caucasians. Graefe’s Archive for Clinical and Experimental Ophthalmology, 254, 2119-2129. [Google Scholar] [CrossRef] [PubMed]
[5] Hsia, Y. and Ho, T.C. (2020) Posterior Staphyloma of Extreme Pathologic Myopia. JAMA Ophthalmology, 138, e191663. [Google Scholar] [CrossRef] [PubMed]
[6] Morgan, I.G., Ohno-Matsui, K. and Saw, S.M. (2012) Myopia. The Lancet, 379, 1739-1748. [Google Scholar] [CrossRef] 
[7] Kim, T.G., Kim, W., Choi, S., et al. (2019) Effects of Scleral Collagen Crosslinking with Different Carbohydrate on Chemical Bond and Ultrastructure of Rabbit Sclera: Future Treat-ment for Myopia Progression. PLOS ONE, 14, e0216425. [Google Scholar] [CrossRef] [PubMed]
[8] Gladek, I., Ferdin, J., Horvat, S., et al. (2017) HIF1A Gene Polymorphisms and Human Diseases: Graphical Review of 97 Association Studies. Genes, Chromosomes and Cancer, 56, 439-452. [Google Scholar] [CrossRef] [PubMed]
[9] Masoud, G.N. and Li, W. (2015) HIF-1α Pathway: Role, Regulation and Intervention for Cancer Therapy. Acta Pharmaceutica Sinica B, 5, 378-389. [Google Scholar] [CrossRef] [PubMed]
[10] Zhao, F., Zhang, D., Zhou, Q., et al. (2020) Scleral HIF-1α Is a Prominent Regulatory Candidate for Genetic and Environmental Interactions in Human Myopia Pathogenesis. EBioMedi-cine, 57, Article ID: 102878. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, Y., Phan, E. and Wildsoet, C.F. (2019) Retinal Defocus and Form-Deprivation Exposure Duration Affects RPE BMP Gene Expression. Scientific Reports, 9, Article No. 7332. [Google Scholar] [CrossRef] [PubMed]
[12] Zhang, Y. and Wildsoet, C.F. (2015) RPE and Choroid Mecha-nisms Underlying Ocular Growth and Myopia. Progress in Molecular Biology and Translational Science, 134, 221-240. [Google Scholar] [CrossRef] [PubMed]
[13] Zhou, X., Pardue, M.T., Iuvone, P.M., et al. (2017) Dopamine Signaling and Myopia Development: What Are the Key Challenges. Progress in Retinal and Eye Research, 61, 60-71. [Google Scholar] [CrossRef] [PubMed]
[14] Reis, R.A., Ventura, A.L., Kubrusly, R.C., et al. (2007) Do-paminergic Signaling in the Developing Retina. Brain Research Reviews, 54, 181-188. [Google Scholar] [CrossRef] [PubMed]
[15] Spix, N.J., Liu, L.L., Zhang, Z., et al. (2016) Vulnerability of Dopaminergic Amacrine Cells to Chronic Ischemia in a Mouse Model of Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science, 57, 3047-3057. [Google Scholar] [CrossRef] [PubMed]
[16] Huang, F., Wang, Q., Yan, T., et al. (2020) The Role of the Dopamine D2 Receptor in Form-Deprivation Myopia in Mice: Studies with Full and Partial D2 Receptor Agonists and Knockouts. Investigative Ophthalmology & Visual Science, 61, Article No. 47. [Google Scholar] [CrossRef] [PubMed]
[17] Li, X., Zhang, Z., Zhang, X., et al. (2019) Transcriptomic Analysis of the Life-Extending Effect Exerted by Black Rice Antho-cyanin Extract in D. melanogaster through Regulation of Aging Pathways. Experimental Gerontology, 119, 33-39. [Google Scholar] [CrossRef] [PubMed]
[18] Ashok, A.H., Mizuno, Y., Volkow, N.D., et al. (2017) Associa-tion of Stimulant Use with Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Sys-tematic Review and Meta-Analysis. JAMA Psychiatry, 74, 511-519. [Google Scholar] [CrossRef] [PubMed]
[19] Jonas, J.B., Wang, Y.X., Dong, L., et al. (2020) Advances in Myopia Research Anatomical Findings in Highly Myopic Eyes. Eye and Vision (London), 7, Article No. 45. [Google Scholar] [CrossRef] [PubMed]
[20] Wu, Y., Ma, Y., Li, J., et al. (2021) The Bioinformatics and Metabolomics Research on Anti-Hypoxic Molecular Mechanisms of Salidroside via Regulating the PTEN Mediated PI3K/Akt/NF-κB Signaling Pathway. Chinese Journal of Natural Medicines, 19, 442-453. [Google Scholar] [CrossRef] 
[21] Zhong, X., Lin, R., Li, Z., et al. (2014) Effects of Salidroside on Cobalt Chloride-Induced Hypoxia Damage and mTOR Signaling Repression in PC12 Cells. Biological and Pharma-ceutical Bulletin, 37, 1199-1206. [Google Scholar] [CrossRef] [PubMed]
[22] Xu, M.C., Shi, H.M., Wang, H., et al. (2013) Salidroside Protects against Hydrogen Peroxide-Induced Injury in HUVECs via the Regulation of REDD1 and mTOR Activation. Molecular Medicine Reports, 8, 147-153. [Google Scholar] [CrossRef] [PubMed]
[23] Zhang, J., Liu, A., Hou, R., et al. (2009) Salidroside Protects Cardi-omyocyte against Hypoxia-Induced Death: A HIF-1alpha-Activated and VEGF-Mediated Pathway. European Journal of Pharmacology, 607, 6-14. [Google Scholar] [CrossRef] [PubMed]
[24] Li, Q.Y., Wang, H.M., Wang, Z.Q., et al. (2010) Salidroside At-tenuates Hypoxia-Induced Abnormal Processing of Amyloid Precursor Protein by Decreasing BACE1 Expression in SH-SY5Y Cells. Neuroscience Letters, 481, 154-158. [Google Scholar] [CrossRef] [PubMed]
[25] Qin, Y., Liu, H.J., Li, M., et al. (2018) Salidroside Improves the Hypoxic Tumor Microenvironment and Reverses the Drug Resistance of Platinum Drugs via HIF-1α Signaling Pathway. EBioMedicine, 38, 25-36. [Google Scholar] [CrossRef] [PubMed]
[26] Chen, X., Kou, Y., Lu, Y., et al. (2020) Salidroside Ameliorated Hypoxia-Induced Tumorigenesis of BxPC-3 Cells via Downregulating Hypoxia-Inducible Factor (HIF)-1α and LOXL2. Journal of Cellular Biochemistry, 121, 165-173. [Google Scholar] [CrossRef] [PubMed]
[27] Li, Y., Pham, V., Bui, M., et al. (2017) Rhodiola rosea L.: An Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention. Current Pharmacology Re-ports, 3, 384-395. [Google Scholar] [CrossRef] [PubMed]
[28] Zhao, J., Zhao, F., Ye, M., et al. (2020) Salidroside Attenuates Hypoxia-Induced Expression of Connexin 43 in Corpus Cavernosum Smooth Muscle Cells. Urologia Internationalis, 104, 594-603. [Google Scholar] [CrossRef] [PubMed]
[29] Wu, Y.L., Piao, D.M., Han, X.H., et al. (2008) Protective Effects of Salidroside against Acetaminophen-Induced Toxicity in Mice. Biological and Pharmaceutical Bulletin, 31, 1523-1529. [Google Scholar] [CrossRef] [PubMed]
[30] Liu, G. and He, L. (2019) Salidroside Attenuates Adriamy-cin-Induced Focal Segmental Glomerulosclerosis by Inhibiting the Hypoxia-Inducible Factor-1α Expression Through Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway. Nephron, 142, 243-252. [Google Scholar] [CrossRef] [PubMed]
[31] Checa, J. and Aran, J.M. (2020) Reactive Oxygen Species: Drivers of Physiological and Pathological Processes. Journal of Inflammation Research, 13, 1057-1073. [Google Scholar] [CrossRef] 
[32] Guo, Q., Yang, J., Chen, Y., et al. (2020) Salidroside Improves Angio-genesis-Osteogenesis Coupling by Regulating the HIF-1α/VEGF Signalling Pathway in the Bone Environment. Europe-an Journal of Pharmacology, 884, Article ID: 173394. [Google Scholar] [CrossRef] [PubMed]
[33] Li, L., Qu, Y., Jin, X., et al. (2016) Protective Effect of Salidroside against Bone Loss via Hypoxia-Inducible Factor-1α Path-way-Induced Angiogenesis. Scientific Reports, 6, Article No. 32131. [Google Scholar] [CrossRef] [PubMed]
[34] Guo, X.Q., Qi, L., Yang, J., Wang, Y., Wang, C., Li, Z.M., Li, L., Qu, Y., Wang, D. and Han, Z.M. (2017) Salidroside Ac-celerates Fracture Healing through Cell-Autonomous and Non-Autonomous Effects on Osteoblasts. Cell and Tissue Re-search, 367, 197-211. [Google Scholar] [CrossRef] [PubMed]
[35] Xie, R.Y., Fang, X.L., Zheng, X.B., et al. (2019) Salidroside and FG-4592 Ameliorate High Glucose-Induced Glomerular Endothelial Cells Injury via HIF Upreg-ulation. Biomedicine & Pharmacotherapy, 118, Article ID: 109175. [Google Scholar] [CrossRef] [PubMed]
[36] Wei, Y., Hong, H., Zhang, X., et al. (2017) Salidroside Inhibits Inflammation through PI3K/Akt/HIF Signaling after Focal Cerebral Ischemia in Rats. Inflammation, 40, 1297-1309. [Google Scholar] [CrossRef] [PubMed]
[37] Metlapally, R. and Wildsoet, C.F. (2015) Scleral Mechanisms Underlying Ocular Growth and Myopia. Progress in Molecular Biology and Translational Science, 134, 241-248. [Google Scholar] [CrossRef] [PubMed]
[38] Wang, W.Y., Chen, C., Chang, J., et al. (2021) Pharmacothera-peutic Candidates for Myopia: A Review. Biomedicine & Pharmacotherapy, 133, Article ID: 111092. [Google Scholar] [CrossRef] [PubMed]

为你推荐