非哺乳期乳腺炎与细胞免疫、体液免疫相关性探讨

Study on the Correlation between Non-Lactating Mastitis and Cellular Immunity, Humoral Immunity

摘要: 目的：探讨细胞免疫、体液免疫与非哺乳期乳腺炎相关性及意义。方法：选取2020年6月至2021年8月至福建省第二人民医院治疗的非哺乳期乳腺炎72例患者作为研究对象，另外选取同期就诊的30例健康人群作为对照组，所有受试者均检测免疫指标IgE、IgG、IgM、IgA、CD3+、CD4+、CD8+、CD4+/CD8+、NK及泌乳素。比较2组成年女性免疫指标有无差异。结果：健康人群组、非哺乳期乳腺炎组2组，采取独立样本t检验，非哺乳期乳腺炎组IgA、CD8+水平高于健康人群组，差异有统计学意义(P < 0.05)。采取独立样本非参数秩和检验，非哺乳期乳腺炎CD3+平均秩次高于健康人群组，差异有统计学意义(P < 0.05)。结论：非哺乳期乳腺炎CD8+、CD3+、IgA均高于正常人群，考虑CD3+、CD8+、IgA共同作用引起免疫功能紊乱，CD3+主要起到信号传导，CD8+细胞主要起杀伤作用，损伤乳腺组织，引起炎症反应。

Abstract: Objective: To investigate the correlation and significance of cellular immunity, humoral immunity and non-lactating mastitis. Methods: 72 patients with non-lactating mastitis who were treated in the Second People’s Hospital of Fujian Province from June 2020 to August 2021 were selected as the study subjects, and 30 healthy people who were treated at the same time were selected as the con-trol group. All the subjects were tested for the immune indicators IgE, IgG, IgM, IgA, CD3+, CD4+, CD8+, CD4+/CD8+, NK and prolactin. We compare the immune indexes of adult women in the two groups. Results: The level of IgA and CD8+in the non lactating mastitis group was higher than that in the healthy group (P < 0.05). Using independent sample nonparametric rank sum test, the aver-age CD3+ rank of non lactating mastitis group was higher than that of the healthy population group, with a statistically significant difference (P < 0.05). Conclusion: CD8+, CD3+ and IgA in non lactating mastitis are higher than those in normal people. Considering the combined effect of CD3+, CD8+ and IgA on immune dysfunction, CD3+ mainly plays a role in signal transduction, and CD8+ cells mainly play a role in killing, damaging breast tissue and causing inflammation.