GnRHa黄体支持在ART中的研究进展
Research Progress of GnRHa Luteal Support in ART
摘要: 目的：根据中国人口协会官方发布数据表明，我国女性不孕症患者正逐年增多，由这一现象带来的连锁反应，不利于家庭和睦和社会稳定。此时辅助生殖技术(ART)作为重要的治疗手段，给患者带来了希望。但ART中存在的黄体功能不全严重影响妊娠结局，需要外源性的黄体支持。目前多项临床研究表明使用GnRHa黄体支持可以提高着床率、临床妊娠率、持续妊娠率、出生率、活产率，明显改善ART妊娠结局。本文将对黄体期添加GnRHa的作用机制及其支持方案进行综述。结论：无论长方案还是拮抗方案鲜胚移植，黄体期添加GnRHa行黄体支持既能解救雌孕激素导致不良妊娠，同时降低发生卵巢过度刺激综合征(OHSS)的风险，拮抗剂的临床效果更优，且长期随访的安全性良好。在人工周期中添加GnRHa，可改善妊娠结局。
Abstract: Objective: According to the official data released by China Population Association, the number of female infertility patients in China is increasing year by year. The chain reaction brought by this phenomenon is not conducive to family harmony and social stability. At this time, assisted repro-ductive technology (ART), as an important means of treatment, brings hope to patients. However, luteal insufficiency in ART seriously affects pregnancy outcome and requires exogenous luteal sup-port. A number of clinical studies have shown that GnRHa luteal support can improve implantation rate, clinical pregnancy rate, persistent pregnancy rate, birth rate, live birth rate, and significantly improve the outcome of ART pregnancy. In this paper, we will review the mechanism of GnRHa sup-plementation in luteal phase and its supporting schemes. Conclusion: Regardless of the long or an-tagonistic regimen of fresh embryo transfer, the addition of GnRHa in the luteal phase for luteal support can not only save the adverse pregnancy caused by estrogen, but also reduce the risk of ovarian hyperstimulation syndrome (OHSS). The clinical effect of the antagonist is better, and the long-term follow-up safety is good. Adding GnRHa to the artificial cycle can improve pregnancy out-comes.
文章引用：王飞. GnRHa黄体支持在ART中的研究进展[J]. 临床医学进展, 2022, 12(10): 9433-9439. https://doi.org/10.12677/ACM.2022.12101364

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