脱矿牙本质基质作为rhBMP-2载体的研究进展
Research Progress of Demineralized Dentin Matrix as rhBMP-2 Carrier
DOI: 10.12677/ACM.2022.12101368, PDF,   
作者: 张 迪, 达尔亚·俄尼木拜：新疆医科大学第一附属医院(附属口腔医院)牙周病科，新疆 乌鲁木齐；古丽努尔·阿吾提*：新疆医科大学第一附属医院(附属口腔医院)牙周病科，新疆 乌鲁木齐；新疆维吾尔自治区口腔医学研究所，新疆 乌鲁木齐
关键词: 脱矿牙本质基质；骨移植材料；骨诱导；骨传导；重组人骨形态发生蛋白-2；Demineralized Dentin Matrix； Bone Graft Material； Osteoinductive； Osteoconductive； Recombinant Human Bone Morphogentic Protein-2
摘要: 骨形态发生蛋白-2 (bone morphogentic protein-2, BMP-2)是转化生长因子-β家族的成员，可促进骨髓间充质干细胞分化为成骨细胞和软骨细胞。脱矿牙本质基质(demineralized dentin matrix, DDM)是由牙本质经过粉碎、脱矿、灭菌等处理后制得，具有良好的骨诱导性、骨传导性和生物相容性等特性，是一种颇有前景的骨移植材料。DDM不仅是一种骨移植材料，也可作为重组人骨形态发生蛋白-2 (recombinant human bone morphogentic protein-2, rhBMP-2)的合适载体。DDM与rhBMP-2有着较好的亲和力，并能够缓释rhBMP-2。此外，外源性的rhBMP-2和DDM中内源性BMP具有协同效应，可产生更多的新骨。DDM用作rhBMP-2载体时，rhBMP-2的浓度可降低为0.2 mg/mL。
Abstract: Bone morphogenetic protein-2 (BMP-2) is a transforming growth factor-β family member. It can promote bone marrow mesenchymal stem cells to differentiate into osteoblasts and chondrocytes. Demineralized dentin matrix (DDM) is prepared from dentin after grinding, demineralization, steri-lization, etc. It has good osteoinductive, osteoconductive, biocompatibility, and is a promising bone graft material. DDM is not only a bone graft material, but also a suitable carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2). DDM has good affinity with rhBMP-2 and can slowly release rhBMP-2. In addition, exogenous rhBMP-2 and endogenous BMP in DDM have syner-gistic effects, which can produce more new bones. When DDM is used as rhBMP-2 carrier, the con-centration of rhBMP-2 can be reduced to 0.2 mg/mL.
文章引用：张迪, 达尔亚·俄尼木拜, 古丽努尔·阿吾提. 脱矿牙本质基质作为rhBMP-2载体的研究进展[J]. 临床医学进展, 2022, 12(10): 9456-9460. https://doi.org/10.12677/ACM.2022.12101368

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