ACS患者NEUT、NLR、PLR与冠脉病变程度关系的研究

Study on the Relationship between NEUT, NLR, PLR and the Severity of Coronary Artery Disease in Patients with ACS

摘要: 目的：分析在急性冠脉综合征(acute coronary syndrome, ACS)患者中中性粒细胞(neutrophil, NEUT)，中性粒细胞与淋巴细胞比率(neutrophil to lymphocyte ratio, NLR)，血小板与淋巴细中性粒细胞比率(platelet to lymphocyte ratio, PLR)与冠脉病变程度的关系。方法：选取2021年8月~2022年8月在青海省人民医院心内科住院行冠状动脉造影检查确诊为ACS的患者为病例组(n ≥ 90)，选取同期行冠状动脉造影检查且为阴性的患者为对照组(n ≥ 90)，比较两组间NEUT、NLR、PLR的水平；病例组患者，根据Gensini评分分为轻度冠脉狭窄组、中度冠脉狭窄组、重度冠脉狭窄组(n ≥ 30)，比较三组间NEUT、NLR、PLR的水平；根据血管病变程度分为单支血管病变组、双支血管病变组、多支血管病变组(n ≥ 30)，比较三组间NEUT、NLR、PLR的水平。结果：ACS组患者NEUT、NLR、PLR均高于对照组；ACS组患者NEUT、NLR、PLR与Gensini评分有相关性；ACS患者NEUT、NLR、PLR与冠脉病变支数有相关性。结论：ACS组患者NEUT、NLR、PLR与冠脉病变程度有明显相关性。

Abstract: Objective: To analyze the relationship between neutrophil, neutrophil to lymphocyte ratio, platelet to lymphoid neutrophil ratio and the severity of coronary artery disease in patients with acute cor-onary syndrome. Methods: From August 2021 to August 2022, patients who were diagnosed as ACS by coronary angiography in the Department of Cardiology of Qinghai People’s Hospital were selected as the case group (n ≥ 90), and patients who were negative by coronary angiography at the same time were selected as the control group (n ≥ 90). The levels of NEUT, NLR, and PLR between the two groups were compared; the patients in the case group were divided into mild coronary stenosis group, moderate coronary stenosis group and severe coronary stenosis group (n ≥ 30) according to the Gensini score. The levels of NEUT, NLR and PLR among the three groups were compared; ac-cording to the degree of vascular disease, they were divided into single vessel disease group, double vessel disease group and multi vessel disease group (n ≥ 30). The levels of NEUT, NLR and PLR among the three groups were compared. Results: The levels of NEUT, NLR and PLR in ACS group were higher than those in control group; in ACS group, NEUT, NLR, PLR were correlated with Gensini score; NEUT, NLR, PLR were correlated with the number of coronary artery lesions in ACS patients. Conclusion: In ACS group, NEUT, NLR, PLR were significantly correlated with the severity of coronary artery disease.