血浆置换治疗一例抗基底膜肾小球肾炎病例报告并文献复习
Plasma Exchange for Anti-Basement Membrane Glomerulonephritis: A Case Report and Literature Review
摘要: 报道1例抗基底膜(glomerular basement membrane, GBM)肾小球肾炎的老年女性患者，经自身抗体检查及临床表现确诊，由血浆置换、激素、免疫抑制剂治疗后抗体恢复正常。进行相关文献查阅并整理，探讨抗基底膜肾小球肾炎的发病机制、流行病学、临床表现、诊疗及预后，以提高对此病的认识。
Abstract: An elderly female patient with anti-basement membrane (GBM) glomerulonephritis was reported. The patient was diagnosed by autoantibody examination and clinical manifestations, and the anti-body recovered after plasma exchange, hormone and immunosuppressive therapy. Relevant liter-ature was reviewed and sorted out, to investigate the pathogenesis, epidemiology, clinical manifes-tations, diagnosis, treatment and prognosis of anti-basement membrane glomerulonephritis, so as to improve the understanding of this disease.
文章引用：田燕敏, 刘金彦. 血浆置换治疗一例抗基底膜肾小球肾炎病例报告并文献复习[J]. 临床医学进展, 2022, 12(11): 10034-10039. https://doi.org/10.12677/ACM.2022.12111447

参考文献

[1] McAdoo, S.P. and Pusey, C.D. (2017) Anti-Glomerular Basement Membrane Disease. Clinical Journal of the American Society of Nephrology, 12, 1162-1172. [Google Scholar] [CrossRef] 
[2] Gulati, K. and McAdoo, S.P. (2018) Anti-Glomerular Basement Membrane Disease. Rheumatic Disease Clinics of North America, 44, 651-673. [Google Scholar] [CrossRef] [PubMed]
[3] Zhou, X.J., et al. (2010) Copy Number Variation of FCGR3A Ra-ther than FCGR3B and FCGR2B Is Associated with Susceptibility to Anti-GBM Disease. International Immunology, 22, 45-51. [Google Scholar] [CrossRef] [PubMed]
[4] Meyer, D., et al. (2013) Case Report of Anti-Glomerular Basement Membrane Disease Following Alemtuzumab Treatment of Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis and Related Disorders, 2, 60-63. [Google Scholar] [CrossRef] [PubMed]
[5] Naylor, R.W., Morais, M. and Lennon, R. (2021) Complexities of the Glomerular Basement Membrane. Nature Reviews Nephrology, 17, 112-127. [Google Scholar] [CrossRef] [PubMed]
[6] Lerner, R.A., Glassock, R.J. and Dixon, F.J. (1967) The Role of Anti-Glomerular Basement Membrane Antibody in the Pathogenesis of Human Glomerulonephritis. Journal of Experi-mental Medicine, 126, 989-1004. [Google Scholar] [CrossRef] [PubMed]
[7] Zhao, J., et al. (2009) The Immunoglobulin G Subclass Distribution of Anti-GBM Autoantibodies against rHalpha3(IV)NC1 Is Associated with Disease Severity. Human Immunology, 70, 425-429. [Google Scholar] [CrossRef] [PubMed]
[8] Cui, Z. and Zhao, M.H. (2005) Avidity of Anti-Glomerular Basement Membrane Autoantibodies Was Associated with Disease Severity. Clinical Immunology, 116, 77-82. [Google Scholar] [CrossRef] [PubMed]
[9] Zou, J., et al. (2008) Healthy Individuals Have Goodpasture Auto-antigen-Reactive T Cells. Journal of the American Society of Nephrology, 19, 396-404. [Google Scholar] [CrossRef] 
[10] Salama, A.D., et al. (2001) In Goodpasture’s Disease, CD4(+) T Cells Escape Thymic Deletion and Are Reactive with the Autoantigen alpha3(IV)NC1. Journal of the American Society of Nephrology, 12, 1908-1915. [Google Scholar] [CrossRef] 
[11] Dean, E.G., et al. (2005) Experimental Autoimmune Goodpasture’s Disease: A Pathogenetic Role for both Effector Cells and Antibody in Injury. Kidney International, 67, 566-575. [Google Scholar] [CrossRef] [PubMed]
[12] Bolton, W.K., et al. (1987) T-Cells and Macrophages in Rapidly Progressive Glomerulonephritis: Clinicopathologic Correlations. Kidney International, 32, 869-876. [Google Scholar] [CrossRef] [PubMed]
[13] Salama, A.D., et al. (2003) Regulation by CD25+ Lymphocytes of Auto-antigen-Specific T-Cell Responses in Goodpasture’s (Anti-GBM) Disease. Kidney International, 64, 1685-1694. [Google Scholar] [CrossRef] [PubMed]
[14] Canney, M., et al. (2016) Spatial and Temporal Clustering of Anti-Glomerular Basement Membrane Disease. Clinical Journal of the American Society of Nephrology, 11, 1392-1399. [Google Scholar] [CrossRef] 
[15] Greco, A., et al. (2015) Goodpasture’s Syndrome: A Clinical Update. Autoimmunity Reviews, 14, 246-253. [Google Scholar] [CrossRef] [PubMed]
[16] Lazor, R., et al. (2007) Alveolar Hemorrhage in Anti-Basement Membrane Antibody Disease: A Series of 28 Cases. Medicine (Baltimore), 86, 181-193. [Google Scholar] [CrossRef] [PubMed]
[17] Cui, Z., et al. (2011) Anti-Glomerular Basement Membrane Disease: Outcomes of Different Therapeutic Regimens in a Large Single-Center Chinese Cohort Study. Medicine, 90, 303-311. [Google Scholar] [CrossRef] 
[18] Huart, A., et al. (2016) Outcomes of Patients with Goodpasture Syndrome: A Nationwide Cohort-Based Study from the French Society of Hemapheresis. Journal of Au-toimmunity, 73, 24-29. [Google Scholar] [CrossRef] [PubMed]
[19] Levy, J.B., et al. (2001) Long-Term Out-come of Anti-Glomerular Basement Membrane Antibody Disease Treated with Plasma Exchange and Immunosuppres-sion. Annals of Internal Medicine, 134, 1033-1042. [Google Scholar] [CrossRef] [PubMed]
[20] Shah, Y., et al. (2012) Rituximab in An-ti-Glomerular Basement Membrane Disease. QJM, 105, 195-197. [Google Scholar] [CrossRef] [PubMed]
[21] Alchi, B., et al. (2015) Predictors of Renal and Patient Outcomes in An-ti-GBM Disease: Clinicopathologic Analysis of a Two-Centre Cohort. Nephrology Dialysis Transplantation, 30, 814-821. [Google Scholar] [CrossRef] [PubMed]

为你推荐