以脊髓半切综合征为首发表现的视神经脊髓炎谱系疾病一例报道并文献复习
Neuromyelitisoptica Spectrum Disease with Brown-Séquard Syndrome as the Initial Presentation: A Case Report and Literature Review
摘要: 目的：探讨视神经脊髓炎谱系疾病(NMOSD)的临床特点，提高对此疾病的认识。方法：报道并回顾性分析1例以脊髓半切综合征(Brown-Séquard Syndrome)为首发症状NMOSD患者的临床资料，并结合文献进行复习。结果：青年女性，首发症状表现为右侧肢体无力及左侧感觉异常，颈椎MRI显示C3-4水平颈髓内可见片状长T2、压脂像异常高信号，相应区域脊髓轻度肿胀增粗，脑脊液水通道蛋白4 (AQP4)抗体阳性；两次分别予大剂量甲泼尼龙冲击治疗后症状明显改善。结论：NMOSD临床特征和影像学表现具有多样性。
Abstract: Objective: To investigate the clinical characteristics of neuromyelitisoptica spectrum disease (NMOSD) and to improve the understanding of this disease. Methods: The clinical data of one case with brown-Sequard Syndrome as the first symptom of NMOSD were reported and analyzed retro-spectively, and the literature was reviewed. Results: In this young woman, the initial symptoms were weakness of the right limbs and left paresthesia. MRI of cervical spine showed long T2 in the cervical medullary at C3-4 level, abnormal high signal of lipid pressure image, mild swelling and thickening of spinal cord in corresponding area, and positive antibody of aquaporin 4 (AQP4) in cerebrospinal fluid. The symptoms were significantly improved after treatment with high dose methylprednisolone. Conclusion: The clinical features and imaging manifestations of NMOSD are diverse.
文章引用：李兰馨, 王澜静, 裴海涛. 以脊髓半切综合征为首发表现的视神经脊髓炎谱系疾病一例报道并文献复习[J]. 临床医学进展, 2022, 12(11): 10052-10058. https://doi.org/10.12677/ACM.2022.12111450

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