不孕症患者及孕前检查者中医证型与临床指标的相关性研究

Study on the Correlation between TCM Syndrome Types and Clinical Indicators of Infertility and Pre-Pregnancy Examiners

摘要: 目的：研究不孕症患者(已发为不孕症)及孕前检查者(尚未发病为不孕症或尚未能诊断为不孕症)不同中医证型与临床指标的相关性，分阶段研究对于不孕症的早防早治意义重大。方法：选取155例不孕症患者及175例孕前检查者，采用Logistic回归分析统计法，分析中医证型与相关临床指标的关系。结果：1) AMH是不孕组肾虚型的保护因素(P < 0.01)，FSH、E2是不孕组肾虚型的危险因素(P < 0.01, P < 0.05)，FSH/AMH、(FSH × E2)/LH、LH是孕前组肾虚型的危险因素(P < 0.01, P < 0.05, P < 0.05)；2) 年龄、AMH、BMI是不孕组痰湿型的危险因素(P < 0.01, P < 0.05, P < 0.05)，AMH是孕前组痰湿型的危险因素(P < 0.01)；3) PRL是不孕组肝郁型的危险因素(P < 0.01)，年龄是孕前组肝郁型的保护因素(P < 0.05)；4) LH是不孕组血瘀型的保护因素(P < 0.05)。结论：不孕症患者与孕前检查者的中医证型与临床指标呈现一定的相关性。

Abstract: Objective: To study the correlation between different TCM syndrome types and clinical indicators of infertility (already diagnosed as infertility) patients and pre-pregnancy examiners (not yet developed infertility or not yet diagnosed as infertility), phase-by-stage study is of great significance to the early prevention and treatment of infertility. Methods: 155 infertility patients and 175 pre-pregnancy examiners were selected, using Logistic regression analysis, analyzing the relationship between TCM syndrome types and related clinical indicators. Results: 1) AMH is a protective factor for kidney deficiency in the infertility group (P < 0.01), FSH, E2 are risk factors for kidney deficiency in the infertility group (P < 0.01, P < 0.05), and FSH/AMH, (FSH × E2)/LH, LH are risk factors for kidney deficiency in the pre-pregnancy group (P < 0.01, P < 0.05, P < 0.05); 2) Age and AMH, BMI are risk factors for phlegm stagnation type in the infertility group (P < 0.01, P < 0.05, P < 0.05), AMH is a risk factor for phlegm stagnation type in pre-pregnancy groups (P < 0.01); 3) PRL is a risk factor for the liver-qi depression type in the infertility group (P < 0.01), Age is a protective factor for liver-qi depression in the pre-pregnancy group (P < 0.05); 4) LH is a protective factor for the blood stasis type in the infertility group (P < 0.05). Conclusion: The TCM syndrome types of infertility patients and pre-pregnancy examiners show a certain correlation with clinical indicators.