米非司酮治疗库欣综合征致意识障碍一例

Mifepristone Treatment of Impaired Consciousness Caused by Cushing Syndrome

摘要: 目的：通过研究米非司酮在库欣综合征患者中的用药方案，增加医生及临床药师对米非司酮治疗库欣综合征药效及不良反应的认识。方法：回顾性研究我院2021年7月30日~2021年12月31日收治的1例接受米非司酮治疗的库欣综合征患者的临床数据及治疗经过。结果：米非司酮能够显著改善患者的高皮质醇血症及相关并发症，但用于基础情况差的老年人应权衡米非司酮严重不良反应的风险。结论：米非司酮应用于库欣综合征患者，可以明显降低高皮质醇水平、血糖水平并且能缓解水肿，但使用时需严密观察意识丧失、低血糖等不良反应的出现。

Abstract: Objective: By studying the medication regimen of mifepristone in patients with Cushing’s syndrome, doctors and clinical pharmacists have increased their understanding of the efficacy and adverse ef-fects of mifepristone in the treatment of Cushing’s syndrome. Methods: A retrospective study was performed on the clinical data and treatment history of a patient with Cushing’s syndrome who re-ceived mifepristone treatment in our hospital from July 30, 2021 to December 31, 2021. Results: Mifepristone can significantly improve hypercortisolemia and associated complications in patients, but should weigh the risk of serious adverse effects of mifepristone in older people with poor un-derlying conditions. Conclusion: Mifepristone used in patients with Cushing’s syndrome can signifi-cantly reduce high cortisol levels, blood sugar levels and relieve edema, but it is necessary to closely observe the occurrence of adverse reactions such as loss of consciousness and hypoglycemia.